William Lee Odell

US Patent:

6139839, Oct 31, 2000

Filed:

Sep 22, 1998

Appl. No.:

9/158565

Inventors:

William D. Odell - Salt Lake City UT
Jeanine T. Griffin - Holladay UT
Sanjeev Grover - Salt Lake City UT
Omar Caticha - Salt Lake City UT
Douglas T. Carrell - West Valley City UT
Marion L. Woods - Salt Lake City UT

Assignee:

University of Utah Research Foundation - Salt Lake City UT

International Classification:

A61K 39395
A61K 3900
C07K 1600

US Classification:

4241301

Abstract:

A method of controlling, in a warm-blooded animal, an infectious microorganism expressing a chorionic gonadotropin-like growth-regulating protein comprises modulating the activity of the protein by administering to the warm-blooded animal an effective amount of an antibody capable of inhibiting the activity of the protein, the chorionic gonadotropin-like growth-regulating protein itself such that the animal develops a neutralizing immune response, or peptides that block the receptors of the chorionic gonadotropin-like growth-regulating protein in the infectious microorganism. Candida albicans is one such microorganism that can be controlled by delivering an antibody against the growth-regulating protein, CaCGLP. Mycobacteria can also be controlled by this method. A method of inhibiting transition of Candida albicans blastospores in vitro by contacting the blastospores with an antibody against CaCGLP is also disclosed.

US Patent:

58112499, Sep 22, 1998

Filed:

Oct 21, 1994

Appl. No.:

8/327362

Inventors:

William D. Odell - Salt Lake City UT
Jeanine T. Griffin - Holladay UT
Omar Caticha - Salt Lake City UT

Assignee:

University of Utah Research Foundation - Salt Lake City UT

International Classification:

G01N 3353
C07K 1614

US Classification:

435 731

Abstract:

A method of controlling, in a warm-blooded animal, an infectious microorganism expressing a chorionic gonadotropin-like growth-regulating protein comprises modulating the activity of the protein by administering to the warm-blooded animal an effective amount of an antibody capable of inhibiting the activity of the protein, the chorionic gonadotropin-like growth-regulating protein itself such that the animal develops a neutralizing immune response, or peptides that block the receptors of the chorionic gonadotropin-like growth-regulating protein in the infectious microorganism. Candida albicans is one such microorganism that can be controlled by delivering an antibody against the growth-regulating protein, CaCGLP. Mycobacteria can also be controlled by this method. A method of inhibiting transition of Candida albicans blastospores in vitro by contacting the blastospores with an antibody against CaCGLP is also disclosed.

US Patent:

52450163, Sep 14, 1993

Filed:

Apr 24, 1991

Appl. No.:

7/690608

Inventors:

William D. Odell - Salt Lake City UT
Sanjeev Grover - Salt Lake City UT
Zeil A. McGee - Salt Lake City UT

Assignee:

University of Utah Research Foundation - Salt Lake City UT

International Classification:

C07L 302
C07K 320
C07K 1504

US Classification:

5303905

Abstract:

A protein isolated from Pseudomonas maltophilia is found to possess an exposed, immunologically accessible protein which binds to the FC region of several species of immunoglobulins. The protein is found to bind both IgG and IgA immunoglobulins and is found to have an effective molecular weight of approximately 30,000 daltons. The protein is found to be useful in isolation of IgA immunoglobulins from biological mixtures. The protein makes IgA immunoglobulins available for further analytical techniques, including identifying bacteria which contain IgA binding proteins. Because of the increased availability of IgA immunoglobulins, it is possible to diagnosis and treat IgA-related diseases and their sources.