William W Sanders

US Patent:

6900200, May 31, 2005

Filed:

Apr 10, 2002

Appl. No.:

10/120100

Inventors:

Amedeo Arturo Failli - Princeton Junction NJ, US
Jay Scott Shumsky - Hightstown NJ, US
Thomas Joseph Caggiano - Morrisville PA, US
Joseph P. Sabatucci - Collegeville PA, US
Eugene John Trybulski - Princeton Junction NJ, US
Kevin Anthony Memoli - Cranbury NJ, US
William Jennings Sanders - Fox Lake IL, US

Assignee:

Wyeth - Madison NJ

International Classification:

C07D487/04
A61K031/5517
A61P015/16

US Classification:

514220, 540561

Abstract:

This invention provides novel substituted tricyclic carboxamides which act as oxytocin receptor competitive antagonists, as well as methods of their manufacture, pharmaceutical compositions and methods of their use in treatment, inhibition, suppression or prevention of preterm labor, dysmenorrhea and endometritis, suppression of labor at term prior to caesarean delivery, and to facilitate antinatal transport to a medical facility. These compounds are also useful in enhancing fertility rates, enhancing survival rates and synchronizing estrus in farm animals; and may be useful in the prevention and treatment of disfunctions of the oxytocin system in the central nervous system including obsessive compulsive disorder (OCD) and neuropsychiatric disorders.

US Patent:

6903087, Jun 7, 2005

Filed:

Apr 10, 2002

Appl. No.:

10/119894

Inventors:

Amedeo Arturo Failli - Princeton Junction NJ, US
William Jennings Sanders - Fox Lake IL, US
Eugene John Trybulski - Princeton Junction NJ, US

Assignee:

Wyeth - Madison NJ

International Classification:

A61K031/33
A61K031/55
C07D487/12

US Classification:

514183, 514220, 540561

Abstract:

The present invention provides novel tricyclic pyridyl carboxamides as well as methods and pharmaceutical compositions utilizing them compounds for the treatment and/or prevention and/or suppression of disorders which may be remedied or alleviated by oxytocin antagonist activity, including prevention and/or suppression of preterm labor, suppression of labor at term prior to caesarean delivery, and for the treatment of dysmenorrhea. These compounds are also useful in enhancing fertility rates, enhancing survival rates and synchronizing estrus in farm animals; and may be useful in the prevention and treatment of disfunctions of the oxytocin system in the central nervous system including obsessive compulsive disorder (OCD) and neuropsychiatric disorders.

US Patent:

6977254, Dec 20, 2005

Filed:

Apr 10, 2002

Appl. No.:

10/119973

Inventors:

Amedeo Arturo Failli - Princeton Junction NJ, US
William Jennings Sanders - Fox Lake IL, US
Eugene John Trybulski - Princeton Junction NJ, US

Assignee:

Wyeth - Madison NJ

International Classification:

C07D487/04
C07D487/14
A61K031/551
A61P005/12

US Classification:

514220, 540561

Abstract:

The present invention provides substituted 10,11-Dihydro-5H-benzo[e]-pyrrolo[1,2-a][1,4]diazepine and 9,10-Dihydro-4H-3a,5,9-triaza-benzo[f]azulene compounds as well as methods and pharmaceutical compositions utilizing these compounds for the treatment and/or prevention and/or suppression of disorders which may be remedied or alleviated by oxytocin antagonist activity, including prevention and/or suppression of preterm labor, suppression labor at term prior to caesarean deliver, and for the treatment of dysmenorrhea. These compounds are also useful in enhancing fertility rates, enhancing survival rates and synchronizing estrus in farm animals.

US Patent:

7022699, Apr 4, 2006

Filed:

Apr 10, 2002

Appl. No.:

10/119611

Inventors:

Amedeo Arturo Failli - Princeton Junction NJ, US
William Jennings Sanders - Fox Lake IL, US
Eugene John Trybulski - Princeton Junction NJ, US

Assignee:

Wyeth - Madison NJ

International Classification:

A61P 15/06
A61K 31/55
C07D 487/12

US Classification:

514220, 514 63, 540561

Abstract:

The present invention provides novel tricyclic diazepine compounds and methods and pharmaceutical compositions utilizing them for the treating or preventing disorders including diabetes insipidus, nocturnal enuresis, nocturia, urinary incontinence, bleeding and coagulation disorders, congestive heart failure or for inducing temporary delay of urination, and in conditions with increased vascular resistance and coronary vasoconstriction; and for the treating or preventing disorders remedied or alleviated by oxytocin antagonist activity, including suppression of preterm labor, dysmenorrhea, endometritis, and for suppressing labor at term prior to caesarean delivery. These compounds are also useful in enhancing fertility rates, enhancing survival rates and synchronizing estrus in farm animals; and treatment of disfunctions of the oxytocin system in the central nervous system including obsessive compulsive disorder (OCD) and neuropsychiatric disorders.

US Patent:

7326700, Feb 5, 2008

Filed:

Apr 10, 2002

Appl. No.:

10/119453

Inventors:

Amedeo Arturo Failli - Princeton Junction NJ, US
Eugene John Trybulski - Huntingdon Valley PA, US
Jay Scott Shumsky - Hightstown NJ, US
William Jennings Sanders - Fox Lake IL, US

Assignee:

Wyeth - Madison NJ

International Classification:

A61P 15/00
A61K 31/55
C07D 487/04

US Classification:

514220, 514 63, 540561

Abstract:

The present invention provides tricyclic carboxamide compounds and methods and pharmaceutical compositions for their use in treatment, prevention, or suppression of disorders which may be remedied or alleviated by oxytocin antagonist activity, including prevention and/or suppression of preterm labor, suppression of labor at term prior to caesarean deliver, and for the treatment of dysmenorrhea. These compounds are also useful in enhancing fertility rates, enhancing survival rates and synchronizing estrus in farm animals; and may be useful in the prevention and treatment of disfunctions of the oxytocin system in the central nervous system including obsessive compulsive disorder (OCD) and neuropsychiatric disorders.

US Patent:

48137588, Mar 21, 1989

Filed:

Apr 27, 1987

Appl. No.:

7/042844

Inventors:

William E. Sanders - Villanova PA

International Classification:

G02B 512
B60Q 1100

US Classification:

350 97

Abstract:

A vehicle parking guide for use on a supporting surface disposed in a preselected travel path. The vehicle parking guide includes a plate adapted to be fixedly mounted on the supporting surface. It also includes lateral vehicle positioning members for ensuring proper lateral vehicle positioning to coincide with the preselected travel path as the vehicle approaches the supporting surface. It further includes a longitudinal vehicle positioning member for ensuring proper longitudinal vehicle positioning to coincide with a preselected stopping point as the vehicle is stopped near the supporting surface. The vehicle parking guide is also provided with at least one fastener capable of fixedly mounting the plate on the supporting surface. With these features, the vehicle parking guide is adapted for properly positioning a vehicle in a preselected position as it is parked.

US Patent:

20200205745, Jul 2, 2020

Filed:

Dec 23, 2019

Appl. No.:

16/725430

Inventors:

- Toronto, CA
Timothy William Fawcett Burton - Toronto, CA
Horace Gillins - Toronto, CA
Shyamlal Ramchandani - Kingston, CA
William Sanders - Bethesda MD, US
Ian Shadforth - Morrisville NC, US

International Classification:

A61B 5/00
G06N 3/08
G06N 20/00
G06K 9/62

Abstract:

The exemplified methods and systems facilitate the configuration and training of a neural network (e.g., a deep neural network, a convolutional neural network (CNN), etc.), or ensemble(s) thereof, with a biophysical signal data set to ascertain estimate for the presence or non-presence of disease or pathology in a subject as well as to assess and/or classify disease or pathology, including for example in some cases the severity of such disease or pathology, in a subject. In the context of the heart, the methods and systems described herein facilitate the configuration and training of a neural network, or ensemble(s) thereof, with a cardiac signal data set to ascertain estimate for the presence or non-presence of coronary artery disease or coronary pathology.

US Patent:

20180000371, Jan 4, 2018

Filed:

Jun 26, 2017

Appl. No.:

15/633330

Inventors:

- Ganaoque, CA
Shyamlal Ramchandani - Kingston, CA
Timothy Burton - Ottawa, CA
William Sanders - Bethesda MD, US
Ian Shadforth - Morrisville NC, US

International Classification:

A61B 5/04
A61B 5/0408
A61B 5/026
A61B 5/1455
A61B 5/00

Abstract:

The present disclosure facilitates the evaluation of wide-band phase gradient information of the heart tissue to assess, e.g., the presence of heart ischemic heart disease. Notably, the present disclosure provides an improved and efficient method to identify and risk stratify coronary stenosis of the heart using a high resolution and wide-band cardiac gradient obtained from the patient. The patient data are derived from the cardiac gradient waveforms across one or more leads, in some embodiments, resulting in high-dimensional data and long cardiac gradient records that exhibit complex nonlinear variability. Space-time analysis, via numeric wavelet operators, is used to study the morphology of the cardiac gradient data as a phase space dataset by extracting dynamical and geometrical properties from the phase space dataset.