William J Tyler

US Patent:

20210077812, Mar 18, 2021

Filed:

Aug 31, 2018

Appl. No.:

16/642750

Inventors:

- Scottsdale AZ, US
William J Tyler - Newton MA, US

Assignee:

Arizona Board of Regents on behalf of Arizona State University - Scottsdale AZ

International Classification:

A61N 1/36
A61N 1/02
A61N 1/04
A61N 1/372

Abstract:

Disclosed herein are an electrode assembly, an in-ear headphone, an in-ear headphone pair, and an electrode pair assembly, each for non-invasive vagus nerve stimulation. Each of the foregoing items includes a first electrode and a second electrode. An electrode assembly configured for insertion into an ear of a user includes a first electrode, a second electrode, and a shim positioned therebetween. An in-ear headphone or headphone pair may include the electrode assembly with a housing and a waveform generator. An electrode pair assembly may include a first electrode configured for insertion into a first ear of a user, and a second electrode configured for insertion into a second ear of the user. Certain embodiments further include audio components positioned within a housing of at least one in-ear headphone to deliver audio stimulation through a central channel of a first electrode or second electrode, respectively.

US Patent:

20200107725, Apr 9, 2020

Filed:

Jun 8, 2018

Appl. No.:

16/618101

Inventors:

- Scottsdale AZ, US
WIlliam Tyler - Newton MA, US

Assignee:

ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY - Scottsdale AZ

International Classification:

A61B 5/00
A61B 5/055
A61B 8/08
G01R 33/563
G01R 33/48

Abstract:

Methods, systems, and devices for mechanically disturbing tissues of the central nervous system including a brain of a subject are provided. An elastogram of brain tissue may be generated using mesoscopic wavelength ultrasound composed of longitudinal waves in brain tissues to produce micromechanical disturbances of brain nuclei and circuits for characterization of their mechanical properties (e.g., stiffness, elasticity, rigidity, viscoelasticity). A magnetic resonance elastography (MRE) system includes an MRE engine in electronic communication with at least one transducer and with a magnetic resonance imaging (MRI) device. The MRE engine is configured to electronically control operation of the at least one transducer to emit ultrasound, to electronically receive, from the MRI device, at least one signal indicative of measurements of displacement of the brain tissue by the ultrasound, and to electronically generate an elastogram of the brain tissue based on the at least one signal.

US Patent:

20190336765, Nov 7, 2019

Filed:

May 20, 2019

Appl. No.:

16/417625

Inventors:

- Los Gatos CA, US
Sumon K. PAL - Boston MA, US
William J. TYLER - Newton MA, US
Daniel Z. WETMORE - Brooklyn NY, US
Isy GOLDWASSER - Los Gatos CA, US
Alyssa M. BOASSO - Brookline MA, US
Hailey M. MORTIMORE - Boston MA, US
Rafal PIERSIAK - Los Gatos CA, US

International Classification:

A61N 1/36

Abstract:

Portable transdermal electrical stimulation (TES) applicators for modifying a subject's cognitive state by applying stimulation to the subject's skin. One or more electrode may be on the subject's mastoid, and/or on or near the back of the subject's neck. The portable applicators are configured and adapted to be lightweight and may be wearable, and to deliver a high-intensity TES able to evoke or enhance a predetermined cognitive effect to stimulate either the trigeminal, facial and/or cervical plexus. These TES applicators may include a pair of electrodes and a TES control module comprising a processor, a timer and a waveform generator.

US Patent:

20170182285, Jun 29, 2017

Filed:

Mar 15, 2017

Appl. No.:

15/460138

Inventors:

William J. TYLER - Newton MA, US
Alyssa M. BOASSO - Brookline MA, US
Hailey M. MORTIMORE - Boston MA, US
Rhonda S. SILVA - Boston MA, US
Sumon K. PAL - Boston MA, US
Jonathan CHARLESWORTH - Menlo Park CA, US
Linh M. AVEN - Boston MA, US

International Classification:

A61M 21/02
A61N 1/36
A61N 1/04

Abstract:

Methods and apparatuses for improving sleep by transdermal electrical stimulation (TES). In general, described herein are methods for applying TES to a subject, and particularly the subject's head (e.g., temple/forehead region) and/or neck with an TES waveform adapted to improve sleep, including reducing sleep onset (falling to sleep) more quickly and/or lengthening the duration of sleep. TES waveform(s) particularly well suited to enhancing sleep are also described herein.

US Patent:

20160346545, Dec 1, 2016

Filed:

Jun 1, 2016

Appl. No.:

15/170878

Inventors:

Sumon K. PAL - Boston MA, US
William J. TYLER - Newton MA, US
Jonathan D. CHARLESWORTH - Boston MA, US
Isy GOLDWASSER - Los Gatos CA, US
Daniel Z. WETMORE - Brooklyn NY, US
Jason EGNAL - Menlo Park CA, US
Anil THAKUR - Fremont CA, US

International Classification:

A61N 1/36
A61N 1/04

Abstract:

Apparatuses and methods of applying transdermal electrical stimulation (TES) to a subject to enhance a concurrent sensory experience, by applying the TES to the subject's head or head and neck from two or more electrodes that are coupled to a neurostimulator. The apparatuses and methods described herein be configured to apply an ensemble current waveform between the two or more electrodes, wherein the ensemble current waveform comprises a series of component waveforms that are sequentially applied, and wherein each component waveform is different from a component waveform immediately before it and wherein transitions between the component waveforms temporally correlates with transitions in the sensory experience. Also described herein are apparatuses and methods for applying TES to a subject's face or face and neck, wherein one end of the TES applicator (e.g., strip electrode) contacts the subject's cheek and/or mastoid. Finally, user interfaces for controlling TES are also described.

US Patent:

20150174403, Jun 25, 2015

Filed:

Mar 4, 2015

Appl. No.:

14/639015

Inventors:

Sumon K. PAL - Boston MA, US
Jonathan CHARLESWORTH - Boston MA, US
Remi DEMERS - Saint-Nicolas, CA
Daniel Z. WETMORE - San Francisco CA, US
Isy GOLDWASSER - Los Gatos CA, US
William J. TYLER - Newton MA, US
Raymond L. GRADWOHL - Saratoga CA, US
Philip LAMB - San Diego CA, US
Christopher VOSS - Dorval, CA

International Classification:

A61N 1/36

Abstract:

Portable transdermal electrical stimulation (TES) applicators for modifying a subject's cognitive state. In general, the portable applicators described are specifically configured and adapted to be lightweight and may be wearable, and to deliver a high-intensity TES able to evoke or enhance a predetermined cognitive effect. These TES applicators may include a pair of electrodes and a TES control module comprising a processor, a timer and a waveform generator. TES control module is adapted to deliver a biphasic electrical stimulation signal of 10 seconds or longer between the first and second electrodes having a frequency of 400 Hz or greater, a duty cycle of greater than 10 percent, an intensity of 3 mA or greater, with a DC offset.

US Patent:

20150005840, Jan 1, 2015

Filed:

Jun 30, 2014

Appl. No.:

14/320443

Inventors:

Sumon K. PAL - Boston MA, US
Jonathan CHARLESWORTH - Boston MA, US
Remi DEMERS - Saint-Nicolas, CA
Daniel Z. WETMORE - San Francisco CA, US
Isy GOLDWASSER - Los Gatos CA, US
William J. TYLER - Roanoke VA, US
Raymond L. GRADWOHL - Saratoga CA, US
Philip LAMB - San Diego CA, US
Christopher VOSS - Dorval, CA

International Classification:

A61N 1/36

US Classification:

607 45

Abstract:

Methods of modifying a subject's cognitive state by applying transdermal electrical stimulation (TES). In particular, described herein are methods of applying TES using a pair of electrodes each positioned at a particular location on the skin of the subject's head, or the head and neck, to evoke a predetermined cognitive state using a TES applicator. In particular, described herein are methods of enhancing attention, alertness, or mental focus or of enhancing a calm or relaxed mental state by applying high-intensity TES across electrodes positioned on the subject's temple and either the mastoid region or on the subject's neck. The subject may control the application directly and TES may be applied by a portable, including wearable, TES applicator.

US Patent:

20150005841, Jan 1, 2015

Filed:

Jun 30, 2014

Appl. No.:

14/320461

Inventors:

Sumon K. PAL - Boston MA, US
Jonathan CHARLESWORTH - Boston MA, US
Remi DEMERS - Saint-Nicolas, CA
Daniel Z. WETMORE - San Francisco CA, US
Isy GOLDWASSER - Los Gatos CA, US
William J. TYLER - Roanoke VA, US
Raymond L. GRADWOHL - Saratoga CA, US
Philip LAMB - San Diego CA, US
Christopher VOSS - Dorval, CA

International Classification:

A61N 1/36
A61N 1/04

US Classification:

607 45

Abstract:

Portable transdermal electrical stimulation (TES) applicators for modifying a subject's cognitive state. In general, the portable applicators described are specifically configured and adapted to be lightweight and may be wearable, and to deliver a high-intensity TES able to evoke or enhance a predetermined cognitive effect. These TES applicators may include a pair of electrodes and a TES control module comprising a processor, a timer and a waveform generator. TES control module is adapted to deliver a biphasic electrical stimulation signal of 10 seconds or longer between the first and second electrodes having a frequency of 400 Hz or greater, a duty cycle of greater than 10 percent, an intensity of 3 mA or greater, with a DC offset.