Woonza M Rhee

US Patent:

6534591, Mar 18, 2003

Filed:

Aug 17, 2001

Appl. No.:

09/932536

Inventors:

Woonza M. Rhee - Palo Alto CA
Frank A. DeLustro - Belmont CA
Richard A. Berg - Los Altos CA

Assignee:

Cohesion Technologies, Inc. - Palo Alto CA

International Classification:

C08F28300

US Classification:

525 541, 525419, 525420, 525425

Abstract:

Crosslinked polymer compositions comprise a first synthetic polymer containing multiple nucleophilic groups covalently bound to a second synthetic polymer containing multiple electrophilic groups. The first synthetic polymer is preferably a synthetic polypeptide or a polyethylene glycol that has been modified to contain multiple nucleophilic groups, such as primary amino (âNH ) or thiol (âSH) groups. The second synthetic polymer may be a hydrophilic or hydrophobic synthetic polymer which contains, or has been derivatized to contain, two or more electrophilic groups, such as succinimidyl groups. The compositions may further comprise other components, such as naturally occurring polysaccharides or proteins (such as glycosaminoglycans or collagen) and/or biologically active agents. Also disclosed are methods for using the crosslinked polymer compositions to effect adhesion between a first surface and a second surface; to effect tissue augmentation; to prevent the formation of surgical adhesions; and to coat a surface of a synthetic implant.

US Patent:

6624245, Sep 23, 2003

Filed:

Nov 5, 2001

Appl. No.:

10/012263

Inventors:

Donald G. Wallace - Menlo Park CA
Gregory M. Cruise - Fremont CA
Woonza M. Rhee - Palo Alto CA
Jacqueline Anne Schroeder - Boulder Creek CA
Marcee M. Maroney - Portola Valley CA
Olof Mikael Trollsas - Los Gatos CA

Assignee:

Cohesion Technologies, Inc. - Palo Alto CA

International Classification:

C08F28300

US Classification:

525 541, 525419, 525420, 525425, 6048911

Abstract:

A method is provided for the rapid formation of a biocompatible gel, and may be carried out in situ, i. e. , at a selected site within a patients body. The method involves admixing a biocompatible crosslinking component A having m sulfhydryl groups wherein m 2 and a biocompatible crosslinking component B having n sulfhydryl-reactive groups wherein n 2 and m+n 4, wherein the sulfhydryl-reactive groups are capable of covalent reaction with the sulfhydryl groups upon admixture of the components under effective crosslinking conditions to form a gel in less than one minute. Suitable reaction conditions for carrying out the crosslinking reaction will depend on the particular components and the type of reaction involved; that is, the âeffective crosslinking conditionsâ may involve reaction in bulk or in a solvent, addition of a base, and/or irradiation of the admixture in the presence of a free radical initiator. Exemplary uses include tissue augmentation, biologically active agent delivery, bioadhesion, and prevention of adhesions following surgery or injury. Reactive gel-forming compositions and systems are also provided.

US Patent:

6911496, Jun 28, 2005

Filed:

Jan 27, 2004

Appl. No.:

10/766726

Inventors:

Woonza M. Rhee - Palo Alto CA, US
Frank A. DeLustro - Belmont CA, US
Richard A. Berg - Los Altos CA, US

Assignee:

Cohesion Technologies, Inc. - Palo Alto CA

International Classification:

C08F283/00
C08G063/48
C08G063/91
C08L077/00

US Classification:

525 541, 525419, 525420, 525425, 6048911

Abstract:

Provided are crosslinked polymer compositions that include a first synthetic polymer containing multiple nucleophilic groups covalently bound to a second synthetic polymer containing multiple electrophilic groups. The first synthetic polymer is preferably a synthetic polypeptide or a polyethylene glycol that has been modified to contain multiple nucleophilic groups, such as primary amino (—NH) or thiol (—SH) groups. The second synthetic polymer may be a hydrophilic or hydrophobic synthetic polymer, which contains or has been derivatized to contain, two or more electrophilic groups, such as succinimidyl groups. The compositions may further include other components, such as naturally occurring polysaccharides or proteins (such as glycosaminoglycans or collagen) and/or biologically active agents. Also disclosed are methods for using the crosslinked polymer compositions to effect adhesion between a first surface and a second surface; to effect tissue augmentation; to prevent the formation of surgical adhesions; and to coat a surface of a synthetic implant.

US Patent:

6962979, Nov 8, 2005

Filed:

Jun 25, 1999

Appl. No.:

09/344230

Inventors:

Woonza M. Rhee - Palo Alto CA, US

Assignee:

Cohesion Technologies, Inc. - Palo Alto CA

International Classification:

C07K014/78

US Classification:

530356, 514 2, 514801

Abstract:

The present invention discloses novel crosslinked biomaterial compsotions which are prepared using hydrophobic polymers as a crosslinking agent. Preferred hydrophobic polymers are those that contain two or more reactive succinimidyl groups, including disuccinimidyl suberate, bix(sulfosuccinimidyl) suberate, and dithiobis(succinimidylpropionate). Crosslinked biomaterial compositions prepared using mixtures of hydrophobic and hydrophilic crosslinking agents are also disclosed. The compositions of the present invention can be used to prepare formed implants for use in a variety of medical applications.

US Patent:

6969400, Nov 29, 2005

Filed:

Jan 27, 2004

Appl. No.:

10/766146

Inventors:

Woonza M. Rhee - Palo Alto CA, US
Frank A. DeLustro - Belmont CA, US
Richard A. Berg - Los Altos CA, US

Assignee:

Cohesion Technologies, Inc. - Palo Alto CA

International Classification:

A61F002/00
A61F002/06
A61F002/12
A61F002/24
A61F002/76
A61M005/00
A61M025/00

US Classification:

623 1, 424423, 604264, 604265, 623 2, 623 8, 623 12, 623900, 623901

Abstract:

Provided are crosslinked polymer compositions that include a first synthetic polymer containing multiple nucleophilic groups covalently bound to a second synthetic polymer containing multiple electrophilic groups. The first synthetic polymer is preferably a synthetic polypeptide or a polyethylene glycol that has been modified to contain multiple nucleophilic groups, such as primary amino (—NH) or thiol (—SH) groups. The second synthetic polymer may be a hydrophilic or hydrophobic synthetic polymer, which contains or has been derivatized to contain, two or more electrophilic groups, such as succinimidyl groups. The compositions may further include other components, such as naturally occurring polysaccharides or proteins (such as glycosaminoglycans or collagen) and/or biologically active agents. Also disclosed are methods for using the crosslinked polymer compositions to effect adhesion between a first surface and a second surface; to effect tissue augmentation; to prevent the formation of surgical adhesions; and to coat a surface of a synthetic implant.

US Patent:

7129209, Oct 31, 2006

Filed:

May 28, 2003

Appl. No.:

10/448246

Inventors:

Woonza M. Rhee - Palo Alto CA, US

Assignee:

Angiotech Pharmaceuticlas (US), Inc. - North Bend WA

International Classification:

C07K 14/78

US Classification:

514 2, 514801, 530356

Abstract:

The present invention discloses novel crosslinked biomaterial compositions which are prepared using hydrophobic polymers as a crosslinking agent. Preferred hydrophobic polymers are those that contain two or more reactive succinimidyl groups, including disuccinimidyl suberate, bis(sulfosuccinimidyl)suberate, and dithiobis(succinimidyl)propionate. Crosslinked biomaterial compositions prepared using mixtures of hydrophobic and hydrophilic crosslinking agents are also disclosed. The compositions of the present invention can be used to prepare formed implants for use in a variety of medical applications.

US Patent:

7151135, Dec 19, 2006

Filed:

Mar 10, 2005

Appl. No.:

11/078254

Inventors:

Woonza M. Rhee - Palo Alto CA, US
Frank A. DeLustro - Belmont CA, US
Richard A. Berg - Los Altos CA, US

Assignee:

Angiotech Pharmaceuticals (US), Inc. - North Bend WA

International Classification:

C08G 63/48
C08G 63/91
C08G 69/48
C08G 77/00
C08L 89/00
C08F 283/00
A61K 47/48

US Classification:

525 541, 525419, 525420, 525425

Abstract:

Provided are crosslinked polymer compositions that include a first synthetic polymer containing multiple nucleophilic groups covalently bound to a second synthetic polymer containing multiple electrophilic groups. The first synthetic polymer is preferably a synthetic polypeptide or a polyethylene glycol that has been modified to contain multiple nucleophilic groups, such as primary amino (—NH) or thiol (—SH) groups. The second synthetic polymer may be a hydrophilic or hydrophobic synthetic polymer, which contains or has been derivatized to contain, two or more electrophilic groups, such as succinimidyl groups. The compositions may further include other components, such as naturally occurring polysaccharides or proteins (such as glycosaminoglycans or collagen) and/or biologically active agents. Also disclosed are methods for using the crosslinked polymer compositions to effect adhesion between a first surface and a second surface; to effect tissue augmentation; to prevent the formation of surgical adhesions; and to coat a surface of a synthetic implant.

US Patent:

7176256, Feb 13, 2007

Filed:

Jun 21, 2004

Appl. No.:

10/873833

Inventors:

Woonza M. Rhee - Palo Alto CA, US
Frank A. DeLustro - Belmont CA, US
Richard A. Berg - Los Altos CA, US

Assignee:

Angiotech Pharmaceuticals (US), Inc. - North Bend WA

International Classification:

C08F 283/00
C08G 63/02
C08G 63/91
C08G 69/48
C08L 89/00
A61K 31/74
A61K 31/785
A61K 47/48

US Classification:

525 541, 525419, 525420, 525425, 424 7802, 424 7803, 424422, 424423, 424424, 424443, 424445, 424486

Abstract:

Crosslinked polymer compositions comprise a first synthetic polymer containing multiple nucleophilic groups covalently bound to a second synthetic polymer containing multiple electrophilic groups. The first synthetic polymer is preferably a synthetic polypeptide or a polyethylene glycol that has been modified to contain multiple nucleophilic groups, such as primary amino (—NH)or thiol (—SH) groups. The second synthetic polymer may be a hydrophilic or hydrophobic synthetic polymer which contains, or has been derivatized to contain, two or more electrophilic groups, such as succinimidyl groups. The compositions may further comprise other components, such as naturally occurring polysaccharides or proteins (such as glycosaminoglycans or collagen) and/or biologically active agents. Also disclosed are methods for using the crosslinked polymmer compositions to effect adhesion between a first surface and a second surface; to effect tissue augmentation; to prevent the formation of surgical adhesions; and to coat a surface of a synthetic implant.