Xi H Chen

US Patent:

20100204120, Aug 12, 2010

Filed:

Feb 8, 2010

Appl. No.:

12/702209

Inventors:

Shibo Jiang - Fresh Meadows NY, US
Zhi Qi - Corona NY, US
Xi Chen - Elmhurst NY, US
Chungen Pan - Guangzho, CN

International Classification:

A61K 38/16
C07K 14/00
A61P 31/18

US Classification:

514 12, 530395

Abstract:

Disclosed herein are trimeric polypeptide pharmaceutical compositions comprising three monomers, each monomer comprising a polypeptide having the amino acid sequence of the N-terminal heptad repeat (NHR or HR1) or C-terminal heptad repeat (CHR or HR2) of the transmembrane glycoprotein of human immunodeficiency virus (HIV) and a trimerization motif.

US Patent:

20120319329, Dec 20, 2012

Filed:

Apr 20, 2012

Appl. No.:

13/452441

Inventors:

Xi Chen - New York NY, US

Assignee:

The Trustees of Columbia University in the City of New York - New York NY

International Classification:

B29C 53/02
B29C 59/02

US Classification:

264320, 425352

Abstract:

Self-assembled buckling patterns of thin films on compliant substrates can be used in micro-fabrication. However, most previous work has been limited to planar substrates, and buckling of films on curved substrates has not been widely explored. With the constraining effect from various types of substrate curvature, numerous new types of buckling morphologies can be derived. The morphologies not only enable true three-dimensional (3D) fabrication of microstructures and microdevices, but also can have important implications for the morphogenesis of quite a few natural and biological systems.

US Patent:

20230058338, Feb 23, 2023

Filed:

May 10, 2019

Appl. No.:

16/408659

Inventors:

- New York NY, US
Onur Cakmak - New York NY, US
Xi Chen - New York NY, US

Assignee:

THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK - New York NY

International Classification:

F03G 7/06
C09J 5/00
C09J 11/00
C08K 11/00

Abstract:

Water-responsive actuators and methods for creating water responsive actuators are disclosed. In some embodiments, the disclosed subject matter includes a first layer, for example a plastic tape, and a second layer, for example bacterial spores and cured adhesive. The second layer can be created in a pattern. The pattern can include joints, which can contract when exposed to dry air and can thereby bend the actuator, and can expand when exposed to humid air and thereby return the actuator its original position.

US Patent:

20210005852, Jan 7, 2021

Filed:

Mar 11, 2019

Appl. No.:

16/979312

Inventors:

- New York NY, US
Guoyu QIAN - Wuhan, CN
Xi CHEN - New York NY, US
Xiangbiao LIAO - New York NY, US
Changmin SHI - College Park MD, US
Tianyang WANG - Columbus OH, US

Assignee:

THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK - New York NY

International Classification:

H01M 2/02
H01M 4/587
H01M 4/38
H01M 4/66
H01M 2/16
H01M 2/20
H01M 10/052
H01M 10/058

Abstract:

An energy storage device is disclosed that includes an axial structure with two or more rigid energy storage units and conductive flexible components separating adjacent rigid energy storage units. The rigid energy storage units include a plurality of folded layers, including an anode layer, a cathode layer, a first current collector layer, a second current collector layer, one or more separator layers, and one or more tape layers. The adjacent rigid energy storage units are produced by folding the plurality of layers one or more times onto themselves at a plurality of locations along the axial structure. The axial structure is then sealed in an aluminized casing along with an electrolyte material. The energy storage device exhibits high energy density, high foldability, and excellent electrochemical performances by virtue of the folded rigid energy storage segments connected by the flexible components. The conductive flexible component functions in a similar way as the soft marrow between vertebrae in the spine, providing excellent overall flexibility.

US Patent:

20150306174, Oct 29, 2015

Filed:

Jul 10, 2015

Appl. No.:

14/796725

Inventors:

- New York NY, US
Zhi Qi - Corona NY, US
Xi Chen - Elmhurst NY, US
Chungen Pan - Guangdong Province, CN

International Classification:

A61K 38/16
C12N 7/00

Abstract:

Disclosed herein are trimeric polypeptide pharmaceutical compositions comprising three monomers, each monomer comprising a polypeptide having the amino acid sequence of the N-terminal heptad repeat (NHR or HR1) or C-terminal heptad repeat (CHR or HR2) of the transmembrane glycoprotein of human immunodeficiency virus (HIV) and a trimerization motif.

US Patent:

20150018406, Jan 15, 2015

Filed:

Mar 11, 2013

Appl. No.:

14/383687

Inventors:

- Ithaca NY, US
Xi Chen - Harrison NJ, US

International Classification:

C12N 15/113
G01N 33/50
G01N 33/574
A61K 45/06
A61K 31/7088

US Classification:

514 44 A, 506 9

Abstract:

Described herein is a previously unknown function of XBP1 in triple-negative breast cancer (TNBC). It is shown that XBP1 is preferentially spliced and activated in TNBC, and that deletion of XBP1 significantly blocks triple negative breast tumor growth. Strikingly, XBP1 is required for the self-renewal of breast tumor initiating cells (TICs). Genome-wide mapping of the XBP1 transcriptional regulatory network identified a fundamental role for XBP1 in regulating the response to hypoxia via the transcription factor hypoxia-inducible factor 1a (HIF1a). Importantly, activation of this pathway appears to carry prognostic implications, as expression of the XBP1-dependent signature is associated with shorter survival times in human TNBC.