Xi I Chen

US Patent:

20220370633, Nov 24, 2022

Filed:

Jun 8, 2022

Appl. No.:

17/835026

Inventors:

- Cambridge MA, US
Xi Chen - West Newton MA, US

Assignee:

Ultivue, Inc. - Cambridge MA

International Classification:

A61K 47/68
G01N 33/58
C07K 16/12
G01N 33/68
C07K 16/42
G01N 33/536

Abstract:

A method for exchange imaging of at least two targets in a sample includes (a) incubating a sample with at least two or more target-recognizing antibodies, each bound to a corresponding monovalent tight antibody binder-docketing moiety (MTAB-DM) reagent capable of binding monovalently to the target-recognizing antibodies, (b) applying at least two imager moieties corresponding to the MTAB-DM, either in series, in batches, or in parallel, and (d) imaging the at least two imager moieties either in series, in batches, or in parallel.

US Patent:

20220311044, Sep 29, 2022

Filed:

Mar 29, 2022

Appl. No.:

17/706754

Inventors:

- Honeoye Falls NY, US
Zhijun Gu - Jingang Town, CN
Joselito Venturina - NEW WESTMINSTER, CA
Xi Chen - Naperville IL, US
Sai Nitin Yellamilli - Naperville IL, US

International Classification:

H01M 10/056
H01M 10/0525

Abstract:

Making a composite solid polymer electrolyte includes mixing a slurry of lithiated ionomer and a doped inorganic ceramic electrolyte and coating the slurry onto a lithiated ionomer membrane. The lithiated ionomer can be provided by exchanging protons of an ionomer membrane with lithium ions to form a lithiated ionomer membrane and dissolving the lithiated ionomer membrane to produce the lithiated ionomer. Various composite solid polymer electrolytes can be made for use in solid-state lithium-ion batteries. Ways of making a dispersion for use in a solid-state electrolyte include lithiating an ionomer by heating and dissoluting to form the dispersion. An ionic liquid and ceramic particles can be added to the dispersion. Ways of making a reinforced solid-state electrolyte for a solid-state lithium-ion battery include infusing a porous membrane with the dispersion.

US Patent:

20230063367, Mar 2, 2023

Filed:

Aug 27, 2021

Appl. No.:

17/459638

Inventors:

Hanna S. CHEN - Aurora IL, US
Xi Chen - Aurora IL, US

International Classification:

A61H 39/06
A61H 39/00

Abstract:

A system for decreasing symptoms of primary dysmenorrhea of a female person/patient. Such system includes an electrical assembly configured for attachment at an acupoint BL57 on each posterior calf skin of the patient proximately mid-length between the ankle and knee region of the patient. Each electrical assembly includes a heating element, a temperature sensor, a heat radiator for dissipating heat generated by the heating element, and an energy source. A pulse generating controller including a computer having logic circuitry powered by the energy source and carried by and arranged in electrical communication with the electrical assembly. The controller operates each heating element through a set or series of immediately consecutive heating and cooling cycles. Each heating and cooling cycle initially involves operating the heating element to warm the person's/patient's skin underlying the heating element as measured by the temperature sensor for a period of 10 to 30 seconds and to a temperature ranging between about 122 F. to about 126 F. Immediately thereafter, the heat exchanger applies a cooling effect to the heating element whereby cooling the heating element as measured by the temperature sensor for a time period of 10 to 60 seconds. A method for decreasing symptoms of primary dysmenorrhea of a female person/patient is also disclosed.

US Patent:

20230027974, Jan 26, 2023

Filed:

Jul 8, 2022

Appl. No.:

17/811486

Inventors:

- Cambridge MA, US
Sarit Agasti - Cambridge MA, US
Xi Chen - Cambridge MA, US
Ralf Jungmann - Cambridge MA, US

Assignee:

President and Fellows of Harvard College - Cambridge MA

International Classification:

C12Q 1/6804
C12Q 1/6818

Abstract:

The present invention provides, inter alia, methods and compositions for imaging, at high spatial resolution, targets of interest.

US Patent:

20210396760, Dec 23, 2021

Filed:

Jun 30, 2021

Appl. No.:

17/363416

Inventors:

- Cambridge MA, US
Xi Chen - West Newton MA, US

Assignee:

Ultivue, Inc. - Cambridge MA

International Classification:

G01N 33/58
G01N 21/64
C07K 16/18
G01N 33/533

Abstract:

An imaging agent comprises (a) at least one target recognition moiety; (b) at least one observable moiety non-transiently bound to the target recognition moiety, and (c) at least one docking moiety bound to the target recognition moiety, wherein the docking moiety is capable of transiently binding at least one observable moiety. In some embodiments, the at least one target recognition moiety is an antibody or antigen binding fragment thereof.

US Patent:

20210292463, Sep 23, 2021

Filed:

Mar 18, 2021

Appl. No.:

17/205206

Inventors:

- Evanston IL, US
Xi Chen - Evanston IL, US
Sumeng Hu - Evanston IL, US
Lingqiao Li - Houston TX, US

International Classification:

C08G 18/10
C08G 18/32
C08G 18/48
C08G 18/20
C08G 18/76
C08J 11/24

Abstract:

Reprocessable crosslinked polyurethane networks, methods for making the reprocessable polyurethane networks, and methods for depolymerizing the crosslinked polyurethane networks and recovering the depolymerized monomers are provided. The polyurethane networks are rendered reprocessable by the incorporation of free hydroxyl groups and the incorporation of multi-functional alcohol crosslinkers.

US Patent:

20210032677, Feb 4, 2021

Filed:

Aug 9, 2018

Appl. No.:

16/637456

Inventors:

- Boston MA, US
Xi Chen - Newton MA, US

Assignee:

RootPath Genomics, Inc. - Boston MA

International Classification:

C12Q 1/6806
C12Q 1/6869
C12N 15/10

Abstract:

The application provides improved methods of analyzing biological particles and their constituents, including methods of generating truncated and barcoded nucleic acid molecules from at least two target polynucleotide sequences, each from distinct biological particles.

US Patent:

20210032693, Feb 4, 2021

Filed:

Aug 9, 2018

Appl. No.:

16/637454

Inventors:

- Boston MA, US
Xi Chen - Newton MA, US

Assignee:

RootPath Genomics, Inc. - Boston MA

International Classification:

C12Q 1/6869
C12Q 1/6806

Abstract:

The application provides improved methods of analyzing biological particles and their constituents, including methods of labeling at least one target nucleic acid molecule from a biological particle with a barcoded primer.