Xi I Chen

US Patent:

6740058, May 25, 2004

Filed:

Jun 8, 2001

Appl. No.:

09/877714

Inventors:

Amit Lal - Madison WI
Xi Chen - Madison WI

Assignee:

Wisconsin Alumni Research Foundation - Madison WI

International Classification:

A61M 3100

US Classification:

604 65, 604 67

Abstract:

A surgical tool with a rigid body including a needle portion for entering tissue includes a fluid flow channel formed therethrough. A sensor is integrally formed on the tool to detect changing conditions (pressure and/or flow) in the channel. The sensor signal may be used to provide feedback control of pumping of fluid through the channel. The tool may be a micromachined silicon tool with the sensor integrally formed thereon from a silicon nitrate membrane and polysilicon resistors. The tool may be an ultrasonically activated cutting tool, which may be bonded to a package at a node thereof.

US Patent:

20220382899, Dec 1, 2022

Filed:

Mar 1, 2022

Appl. No.:

17/684184

Inventors:

- Mountain View CA, US
Xi Chen - Davis CA, US
Amrit Jassal - Morgan Hill CA, US
Daniel H. Jung - San Ramon CA, US
Gregory B. Neustaetter - Sunnyvale CA, US
Sean H. Puttergill - Sunnyvale CA, US
Ramakrishnan Sundararaj - Sunnyvale CA, US
Sanjay Vedanthan - Santa Clara CA, US
Chandra Yalangi - San Jose CA, US
Ramanathan Kavasseri - Fremont CA, US
Ravi Wijayaratne - San Jose CA, US
Shishir Sharma - Mountain View CA, US

Assignee:

Egnyte, Inc. - Mountain View CA

International Classification:

G06F 21/62
G06F 15/173
G06F 16/14
G06F 16/27
G06F 16/11
G06F 16/178
G06F 16/182
H04L 9/40

Abstract:

A method for providing access to objects associated with a particular client in a cloud storage system is disclosed. The method includes the steps of establishing a connection with a user, providing a client namespace associated with the client to the user, where the client namespace represents objects stored on the cloud storage system and objects stored on a private storage system apart from the cloud storage system, receiving a request from the user to access an object stored on the private storage system, and providing information to the user to facilitate access to the object stored on the private storage system by said user. Other systems and methods are also disclosed. Important advantages of the present invention are facilitated by separating the logic for user access (control plane) from the actual storage (Storage plane). Private file system access can still be managed from the cloud, while keeping the client data private.

US Patent:

20220370633, Nov 24, 2022

Filed:

Jun 8, 2022

Appl. No.:

17/835026

Inventors:

- Cambridge MA, US
Xi Chen - West Newton MA, US

Assignee:

Ultivue, Inc. - Cambridge MA

International Classification:

A61K 47/68
G01N 33/58
C07K 16/12
G01N 33/68
C07K 16/42
G01N 33/536

Abstract:

A method for exchange imaging of at least two targets in a sample includes (a) incubating a sample with at least two or more target-recognizing antibodies, each bound to a corresponding monovalent tight antibody binder-docketing moiety (MTAB-DM) reagent capable of binding monovalently to the target-recognizing antibodies, (b) applying at least two imager moieties corresponding to the MTAB-DM, either in series, in batches, or in parallel, and (d) imaging the at least two imager moieties either in series, in batches, or in parallel.

US Patent:

20230027974, Jan 26, 2023

Filed:

Jul 8, 2022

Appl. No.:

17/811486

Inventors:

- Cambridge MA, US
Sarit Agasti - Cambridge MA, US
Xi Chen - Cambridge MA, US
Ralf Jungmann - Cambridge MA, US

Assignee:

President and Fellows of Harvard College - Cambridge MA

International Classification:

C12Q 1/6804
C12Q 1/6818

Abstract:

The present invention provides, inter alia, methods and compositions for imaging, at high spatial resolution, targets of interest.

US Patent:

20210396760, Dec 23, 2021

Filed:

Jun 30, 2021

Appl. No.:

17/363416

Inventors:

- Cambridge MA, US
Xi Chen - West Newton MA, US

Assignee:

Ultivue, Inc. - Cambridge MA

International Classification:

G01N 33/58
G01N 21/64
C07K 16/18
G01N 33/533

Abstract:

An imaging agent comprises (a) at least one target recognition moiety; (b) at least one observable moiety non-transiently bound to the target recognition moiety, and (c) at least one docking moiety bound to the target recognition moiety, wherein the docking moiety is capable of transiently binding at least one observable moiety. In some embodiments, the at least one target recognition moiety is an antibody or antigen binding fragment thereof.

US Patent:

20210032677, Feb 4, 2021

Filed:

Aug 9, 2018

Appl. No.:

16/637456

Inventors:

- Boston MA, US
Xi Chen - Newton MA, US

Assignee:

RootPath Genomics, Inc. - Boston MA

International Classification:

C12Q 1/6806
C12Q 1/6869
C12N 15/10

Abstract:

The application provides improved methods of analyzing biological particles and their constituents, including methods of generating truncated and barcoded nucleic acid molecules from at least two target polynucleotide sequences, each from distinct biological particles.

US Patent:

20210032693, Feb 4, 2021

Filed:

Aug 9, 2018

Appl. No.:

16/637454

Inventors:

- Boston MA, US
Xi Chen - Newton MA, US

Assignee:

RootPath Genomics, Inc. - Boston MA

International Classification:

C12Q 1/6869
C12Q 1/6806

Abstract:

The application provides improved methods of analyzing biological particles and their constituents, including methods of labeling at least one target nucleic acid molecule from a biological particle with a barcoded primer.

US Patent:

20200371097, Nov 26, 2020

Filed:

Aug 13, 2020

Appl. No.:

16/992654

Inventors:

- Cambridge MA, US
Mael MANESSE - Medford MA, US
Abdul MOHAMMED - Cambridge MA, US
Xi CHEN - West Newton MA, US
Michael Jules NATAN - Weston MA, US

Assignee:

Ultivue, Inc. - Cambridge MA

International Classification:

G01N 33/543
C12Q 1/6816
G01N 33/58
C12Q 1/6823
C12Q 1/6818
C12Q 1/6806
C12Q 1/68
C12Q 1/6874
C12Q 1/6832
C12Q 1/6804
C12Q 1/682

Abstract:

The present application provides certain advantageous ways of conducting multiplexed imaging.