Xi I Chen

US Patent:

8163281, Apr 24, 2012

Filed:

Mar 3, 2010

Appl. No.:

12/716842

Inventors:

Yang Liu - Ann Arbor MI, US
Pan Zheng - Ann Arbor MI, US
Xincheng Zheng - Ann Arbor MI, US
Xi Chen - Woodland CA, US
Steve Kunkel - Ann Arbor MI, US

Assignee:

The Regents Of The University Of Michigan - Ann Arbor MI

International Classification:

A61K 39/395
A61K 39/00
A61K 38/16

US Classification:

4241301, 4241431, 4241841, 4241851, 514 212

Abstract:

The present technology provides methods and compositions for the treatment of tissue-damage related immune dysregulation by administering a composition comprising one or more of CD24; CD24 fragments, variants and derivatives, CD24Fc fusion proteins; HMBG1-binding proteins, binding proteins to HMBG1 Box B; antagonists of HMGB1, polyclonal, monoclonal, recombinant, chimeric, humanized scFv antibodies and antibody fragments to HMGB1 or fragments of HMGB1 and antibodies that bind and suppress the activity of HMGB1 Box B; Siglec 10 agonists such as anti-Siglec 10 antibodies; and combinations thereof to a patient.

US Patent:

20020132320, Sep 19, 2002

Filed:

Jan 10, 2001

Appl. No.:

09/758525

Inventors:

Peng Wang - Troy MI, US
Xi Chen - Norristown PA, US
Ziye Liu - Detroit MI, US
Wei Zhang - Detroit MI, US

International Classification:

C12P019/04
C12N009/10
C12N009/24
C12N015/00

US Classification:

435/193000, 435/200000, 435/320100, 435/325000, 435/101000

Abstract:

This invention relates to methods and compositions for the production of glycoconjugates. In particular, organisms are provided with at least one heterologous gene encoding an enzyme for regenerating a sugar nucleotide along with at least one glycosyltransterase. Such organisms are useful for the large-scale synthesis of glycoconjugates.

US Patent:

20020150968, Oct 17, 2002

Filed:

Jan 10, 2001

Appl. No.:

09/757846

Inventors:

Peng Wang - Troy MI, US
Xi Chen - Norristown PA, US

International Classification:

C12P033/20
C12P021/02
C12P019/20
C12N011/18

US Classification:

435/053000, 435/068100, 435/096000, 435/175000

Abstract:

This invention relates to methods and compositions for the in vitro production of glycoconjugates. In particular, a preferred production system is provided that comprises a solid support, at least one sugar nucleotide producing enzyme, at least one glycosyltransferase, at least one bioenergetic, and at least one acceptor. The sugar nucleotide producing enzyme(s) is preferably immobilized on the solid support. The glycosyltransferase may be co-immobilized on the solid support with the sugar nucleotide producing enzyme(s), or may be provided to the solid support in solution.

US Patent:

20100202496, Aug 12, 2010

Filed:

Jan 21, 2010

Appl. No.:

12/691334

Inventors:

Sebastian Hoyos - Bryan TX, US
Mandar S. Kulkarni - College Station TX, US
Pradeep Kotte Prakasam - College Station TX, US
Xi Chen - College Station TX, US
Brian Marshall Sadler - Laurel MD, US

Assignee:

THE TEXAS A&M UNIVERSITY SYSTEM - College Station TX

International Classification:

H04L 27/06
H04B 1/16
H04B 1/707

US Classification:

375147, 455334, 375340, 375E01002

Abstract:

A system is provided. The system comprises a transform domain radio receiver comprising a plurality of reconfigurable processing paths coupled to a radio frequency signal input, each reconfigurable processing path implementing a down converter, a low-pass filter, and an integrator and wherein a frequency selectivity of the processing path is reconfigurable. The system also comprises a control unit to configure a frequency selectivity of the plurality of parallel reconfigurable processing paths.

US Patent:

20110004575, Jan 6, 2011

Filed:

Jun 9, 2010

Appl. No.:

12/796934

Inventors:

Lei Yang - Sunnydale CA, US
Robert P. Dick - Chelsea MI, US
Xi Chen - San Jose CA, US
Gokhan Memik - Evanston IL, US
Peter A. Dinda - Evanston IL, US
Alex Shye - Evanston IL, US
Berkin Ozisikyilmaz - Chicago IL, US
Arindam Mallik - Leuven, BE
Alok Choudhary - Chicago IL, US

International Classification:

G06F 15/18
G06F 1/32
G06F 1/26

US Classification:

706 12, 713320, 713300

Abstract:

Systems and methods for controlling power consumption in a computer system are disclosed. The computer system may be trained, for example, to determine relationship information between user satisfaction and discrete frequencies at which a processor of the computer system runs. The determined relationship can distinguish between different users and different interactive applications. A frequency may be selected from the discrete frequencies at which the processor of the computer system runs based on the determined relationship information for a particular user and a particular interactive application running on the processor of the computer system. The processor may be adapted to run at the selected frequency.

US Patent:

20120201819, Aug 9, 2012

Filed:

Mar 21, 2012

Appl. No.:

13/426392

Inventors:

Yang LIU - Ann Arbor MI, US
Pan ZHENG - Ann Arbor MI, US
Xi CHEN - Woodland CA, US
Steve KUNKEL - Ann Arbor MI, US
Xincheng ZHENG - Ann Arbor MI, US

Assignee:

THE REGENTS OF THE UNIVERSITY OF MICHIGAN - Ann Arbor MI

International Classification:

A61K 39/395
A61K 31/7008
A61P 29/00
A61K 31/715

US Classification:

4241341, 4241731, 514 54, 514 23

Abstract:

The present technology provides methods and compositions for the treatment of tissue-damage related immune dysregulation by administering a composition comprising one or more of CD24; CD24 fragments, variants and derivatives, CD24Fc fusion proteins; HMBG1-binding proteins, binding proteins to HMBG1 Box B; antagonists of HMGB1, polyclonal, monoclonal, recombinant, chimeric, humanized scFv antibodies and antibody fragments to HMGB1 or fragments of HMGB1 and antibodies that bind and suppress the activity of HMGB1 Box B; Siglec 10 agonists such as anti-Siglec 10 antibodies; and combinations thereof to a patient.