Xi I Chen

US Patent:

6426347, Jul 30, 2002

Filed:

Dec 13, 2000

Appl. No.:

09/736566

Inventors:

Andrew Thurkauf - Danbury CT
Xi Chen - Clinton CT

Assignee:

Neurogen Corporation - Branford CT

International Classification:

C07D295073

US Classification:

51425503, 544392

Abstract:

Disclosed are compounds of the formula: or the pharmaceutically acceptable addition salts thereof wherein: R is halogen or C -C alkyl; and R and R are the same or different and represent hydrogen, halogen, C -C alkyl, C -C alkoxy, alkylthio, hydroxy, amino, mono(C -C )alkylamino, di(C -C )alkylamino, or R and R together represent a 4 carbon alkenylene moiety that together with the phenyl ring to which they are attached form a naphthyl moiety, which compounds are useful in the treatment of neuropsycological diseases such as schizophrenia, psychotic depression and mania.

US Patent:

6656943, Dec 2, 2003

Filed:

Jun 28, 2002

Appl. No.:

10/186235

Inventors:

Andrew Thurkauf - Danbury CT
Xi Chen - Clinton CT

Assignee:

Neurogen Corporation - Branford CT

International Classification:

A61K 31495

US Classification:

51425503, 544392

Abstract:

Disclosed are compounds of the formula: or the pharmaceutically acceptable addition salts thereof wherein: R is halogen or C -C alkyl; and R and R are the same or different and represent hydrogen, halogen, C -C alkyl, C -C alkoxy, alkylthio, hydroxy, amino, mono(C -C )alkylamino, di(C -C )alkylamino, or R and R together represent a 4 carbon alkenylene moiety that together with the phenyl ring to which they are attached form a naphthyl moiety, which compounds are useful in the treatment of neuropsycological diseases such as schizophrenia, psychotic depression and mania.

US Patent:

7101887, Sep 5, 2006

Filed:

Jun 27, 2005

Appl. No.:

11/167735

Inventors:

Andrew Thurkauf - Danbury CT, US
Xi Chen - Clinton CT, US

Assignee:

Neurogen Corporation - Branford CT

International Classification:

A61K 31/495
C07D 295/076

US Classification:

51425503, 544392

Abstract:

Disclosed are compounds of the formula:.

US Patent:

20040083447, Apr 29, 2004

Filed:

Sep 22, 2003

Appl. No.:

10/667821

Inventors:

Andrew Thurkauf - Danbury CT, US
Xi Chen - Clinton CT, US

Assignee:

Neurogen Corporation, A Corporation of the State of Delaware - Branford CT

International Classification:

G06F009/44

US Classification:

717/100000, 717/105000

Abstract:

Disclosed are compounds of the formula: or the pharmaceutically acceptable addition salts thereof wherein: Ris halogen or C-Calkyl; and Rand Rare the same or different and represent hydrogen, halogen, C-Calkyl, C-Calkoxy, alkylthio, hydroxy, amino, mono(C-C)alkylamino, di(C-C)alkylamino, or Rand Rtogether represent a 4 carbon alkenylene moiety that together with the phenyl ring to which they are attached form a naphthyl moiety, which compounds are useful in the treatment of neuropsycological diseases such as schizophrenia, psychotic depression and mania.

US Patent:

20100204120, Aug 12, 2010

Filed:

Feb 8, 2010

Appl. No.:

12/702209

Inventors:

Shibo Jiang - Fresh Meadows NY, US
Zhi Qi - Corona NY, US
Xi Chen - Elmhurst NY, US
Chungen Pan - Guangzho, CN

International Classification:

A61K 38/16
C07K 14/00
A61P 31/18

US Classification:

514 12, 530395

Abstract:

Disclosed herein are trimeric polypeptide pharmaceutical compositions comprising three monomers, each monomer comprising a polypeptide having the amino acid sequence of the N-terminal heptad repeat (NHR or HR1) or C-terminal heptad repeat (CHR or HR2) of the transmembrane glycoprotein of human immunodeficiency virus (HIV) and a trimerization motif.

US Patent:

20110171093, Jul 14, 2011

Filed:

Jan 11, 2011

Appl. No.:

13/004606

Inventors:

Gary Rochelle - Austin TX, US
Stephanie Freeman - Austin TX, US
Xi Chen - Austin TX, US
Thu Nguyen - Austin TX, US
Alexander Voice - Austin TX, US
Humera Rafique - Austin TX, US

International Classification:

B01D 53/62
B01F 1/00

US Classification:

423228, 252364

Abstract:

Compositions and methods related to the removal of acidic gas. In one embodiment, compositions and methods are provided for the removal of acidic gas from a gas mixture using an aqueous amine solvent comprising water, a first amine, and a second amine, wherein the first amine contributes at least 50% by weight of the solvent's total amine concentration.

US Patent:

20110198101, Aug 18, 2011

Filed:

Aug 19, 2009

Appl. No.:

12/998384

Inventors:

Aaron W. Sanders - Missouri City TX, US
Ed G. Rightor - Maidland MI, US
Keith p. Johnston - Austin TX, US
Stephanie Adkins - Austin TX, US
Quoc Nguyen - Austin TX, US
Xi Chen - Austin TX, US

International Classification:

E21B 43/16
C07C 43/04

US Classification:

166402, 568679

Abstract:

Embodiments of the present disclosure include compositions for use in enhanced oil recovery, and methods of using the compositions for recovering oil. Compositions of the present disclosure include a nonionic, non-emulsifying surfactant having a CO-philicity in a range of about 1.5 to about 5.0, carbon dioxide in a liquid phase or supercritical phase, and water, where the nonionic, non-emulsifying surfactant promotes a formation of a stable foam formed of carbon dioxide and water.

US Patent:

20120103635, May 3, 2012

Filed:

Aug 19, 2009

Appl. No.:

13/382166

Inventors:

Aaron W. Sanders - Missouri City TX, US
Keith P. Johnston - Austin TX, US
Quoc Nguyen - Austin TX, US
Stephanie Adkins - Austin TX, US
Xi Chen - Austin TX, US
Ed G. Rightor - Midland MI, US

International Classification:

E21B 43/16

US Classification:

166402

Abstract:

Embodiments of the present disclosure include dispersion compositions having a nonionic surfactant for use in enhanced petroleum recovery, and methods of using the dispersion compositions in petroleum recovery processes. For the various embodiments, the nonionic surfactant of the dispersion composition promotes the formation of a dispersion from carbon dioxide and water.