Xi I Chen

US Patent:

6429312, Aug 6, 2002

Filed:

Mar 19, 2001

Appl. No.:

09/812199

Inventors:

Jun Yuan - Clinton CT
Xi Chen - New Haven CT

Assignee:

Neurogen Corporation - Branford CT

International Classification:

C07D40914

US Classification:

544295, 544363, 544364, 544375, 544376, 544333, 5462811, 546146, 546175, 546194, 546202, 546256, 549 43, 549 48

Abstract:

Disclosed are compounds of the formula: or the pharmaceutically acceptable acid addition salts thereof, wherein: R , R , R , R are the same or different and represent hydrogen, C -C alkyl, halogen, hydroxy, amino, cyano, nitro, trifluoromethyl, trifluoromethoxy, C -C alkoxy, âO CRâ, âNHCORâ, âCORâ, âSO Râ, where Râ is C -C alkyl and wherein m is 0, 1 or 2; or R , R , R , R independently represent âCONRâRâ, or âNRâRâ where Râ and Râ independently represent hydrogen or C -C alkyl; R is hydrogen or C -C alkyl; and R represents an aminoalkyl group, which compounds are useful in the treatment of affective disorders such as schizophrenia, depression, Alzheimers disease, movement disorders such as Parkinsonism and dystonia, and other disorders which respond to dopaminergic blockade such as substance abuse and obsessive compulsive disorders. Further, compounds of this invention may be useful in treating the extrapyramidal side effects associated with the use of conventional neuroleptic agents.

US Patent:

20100202496, Aug 12, 2010

Filed:

Jan 21, 2010

Appl. No.:

12/691334

Inventors:

Sebastian Hoyos - Bryan TX, US
Mandar S. Kulkarni - College Station TX, US
Pradeep Kotte Prakasam - College Station TX, US
Xi Chen - College Station TX, US
Brian Marshall Sadler - Laurel MD, US

Assignee:

THE TEXAS A&M UNIVERSITY SYSTEM - College Station TX

International Classification:

H04L 27/06
H04B 1/16
H04B 1/707

US Classification:

375147, 455334, 375340, 375E01002

Abstract:

A system is provided. The system comprises a transform domain radio receiver comprising a plurality of reconfigurable processing paths coupled to a radio frequency signal input, each reconfigurable processing path implementing a down converter, a low-pass filter, and an integrator and wherein a frequency selectivity of the processing path is reconfigurable. The system also comprises a control unit to configure a frequency selectivity of the plurality of parallel reconfigurable processing paths.

US Patent:

57636095, Jun 9, 1998

Filed:

Mar 21, 1996

Appl. No.:

8/619429

Inventors:

Jun Yuan - Clinton CT
Xi Chen - New Haven CT

Assignee:

Neurogen Corporation - Branford CT

International Classification:

C07D40914
C07D40912

US Classification:

544363

Abstract:

Disclosed are compounds of the formula: ##STR1## or the pharmaceutically acceptable acid addition salts thereof, wherein: R. sub. 1, R. sub. 2, R. sub. 3, R. sub. 4 are the same or different and represent hydrogen, C. sub. 1 -C. sub. 6 alkyl, halogen, hydroxy, amino, cyano, nitro, trifluoromethyl, trifluoromethoxy, C. sub. 1 -C. sub. 6 alkoxy, --O. sub. 2 CR', --NHCOR', --COR', --SO. sub. m R', where R' is C. sub. 1 -C. sub. 6 alkyl and wherein m is 0, 1 or 2; or R. sub. 1, R. sub. 2, R. sub. 3, R. sub. 4 independently represent --CONR'R", or --NR'R" where R' and R" independently represent hydrogen or C. sub. 1 -C. sub. 6 alkyl; R. sub. 5 is hydrogen or C. sub. 1 -C. sub. 6 alkyl; and R represents an aminoalkyl group, which compounds are useful in the treatment of affective disorders such as schizophrenia, depression, Alzheimer's disease, movement disorders such as Parkinsonism and dystonia, and other disorders which respond to dopaminergic blockade such as substance abuse and obsessive compulsive disorders. Further, compounds of this invention may be useful in treating the extrapyramidal side effects associated with the use of conventional neuroleptic agents.

US Patent:

57032351, Dec 30, 1997

Filed:

Mar 21, 1996

Appl. No.:

8/619351

Inventors:

Jun Yuan - Clinton CT
Xi Chen - New Haven CT

Assignee:

Neurogen Corporation - Branford CT

International Classification:

C07D40110
C07D29515
C07D21114
C07D21170

US Classification:

544363

Abstract:

Disclosed are compounds of the formula: ##STR1## or the pharmaceutically acceptable acid addition salts thereof, wherein: R. sub. 1, R. sub. 2, R. sub. 3, R. sub. 4, R. sub. 5, R. sub. 6, R. sub. 7, R. sub. 8 and R. sub. 9 are the same or different and represent hydrogen, C. sub. 1 -C. sub. 6 alkyl, halogen, hydroxy, amino, cyano, nitro, trifluoromethyl, trifluoromethoxy, C. sub. 1 -C. sub. 6 alkoxy, --O. sub. 2 CR', --NHCOR', --COR', --SO. sub. m R', where R' is C. sub. 1 -C. sub. 6 alkyl and wherein m is 0, 1 or 2; or R. sub. 1, R. sub. 2, R. sub. 3, R. sub. 4, R. sub. 5, R. sub. 6, R. sub. 7, R. sub. 8 and R. sub. 9 independently represent --CONR'R", or --NR'R" where R' and R" independently represent hydrogen or C. sub. 1 -C. sub. 6 alkyl; R. sub. 10 is hydrogen or C. sub. 1 -C. sub.

US Patent:

58832572, Mar 16, 1999

Filed:

Dec 19, 1997

Appl. No.:

8/994588

Inventors:

Jun Yuan - Clinton CT
Xi Chen - New Haven CT

Assignee:

Neurogen Corporation - Branford CT

International Classification:

C07D40112
C07D21170
C07D21114

US Classification:

546203

Abstract:

Disclosed are compounds of the formula: ##STR1## or the pharmaceutically acceptable acid addition salts thereof, wherein: R. sub. 1, R. sub. 2, R. sub. 3, R. sub. 4, R. sub. 5, R. sub. 6, R. sub. 7, R. sub. 8 and R. sub. 9 are the same or different and represent hydrogen, C. sub. 1 -C. sub. 6 alkyl, halogen, hydroxy, amino, cyano, nitro, trifluoromethyl, trifluoromethoxy, C. sub. 1 -C. sub. 6 alkoxy, --O. sub. 2 CR', --NHCOR', --COR', --SO. sub. m R', where R' is C. sub. 1 -C. sub. 6 alkyl and wherein m is 0, 1 or 2; or R. sub. 1, R. sub. 2, R. sub. 3, R. sub. 4, R. sub. 5, R. sub. 6, R. sub. 7, R. sub. 8 and R. sub. 9 independently represent --CONR'R", or --NR'R" where R' and R" independently represent hydrogen or C. sub. 1 -C. sub. 6 alkyl; R. sub. 10 is hydrogen or C. sub. 1 -C. sub.

US Patent:

60404590, Mar 21, 2000

Filed:

Aug 5, 1999

Appl. No.:

9/368542

Inventors:

Jun Yuan - Clinton CT
Xi Chen - New Haven CT

Assignee:

Neurogen Corporation - Branford CT

International Classification:

C07D33376

US Classification:

549 43

Abstract:

Disclosed are compounds of the formula: ##STR1## or the pharmaceutically acceptable acid addition salts thereof, wherein: R. sub. 1, R. sub. 2, R. sub. 3, R. sub. 4 are the same or different and represent hydrogen, C. sub. 1 -C. sub. 6 alkyl, halogen, hydroxy, amino, cyano, nitro, trifluoromethyl, trifluoromethoxy, C. sub. 1 -C. sub. 6 alkoxy, --O. sub. 2 CR', --NHCOR', --COR', --SO. sub. m R', where R' is C. sub. 1 -C. sub. 6 alkyl and wherein m is 0, 1 or 2; or R. sub. 1, R. sub. 2, R. sub. 3, R. sub. 4 independently represent --CONR'R", or --NR'R" where R' and R" independently represent hydrogen or C. sub. 1 -C. sub. 6 alkyl; R. sub. 5 is hydrogen or C. sub. 1 -C. sub. 6 alkyl; and R represents an aminoalkyl group, which compounds are useful in the treatment of affective disorders such as schizophrenia, depression, Alzheimer's disease, movement disorders such as Parkinsonism and dystonia, and other disorders which respond to dopaminergic blockade such as substance abuse and obsessive compulsive disorders. Further, compounds of this invention may be useful in treating the extrapyramidal side effects associated with the use of conventional neuroleptic agents.

US Patent:

62391798, May 29, 2001

Filed:

Feb 4, 2000

Appl. No.:

9/497989

Inventors:

Jun Yuan - Clinton CT
Xi Chen - New Haven CT

Assignee:

Neurogen Corporation - Branford CT

International Classification:

A61K 31166
C07C23379

US Classification:

514617

Abstract:

Disclosed are compounds of the formula: ##STR1## or the pharmaceutically acceptable acid addition salts thereof, wherein: R. sub. 1, R. sub. 2, R. sub. 3, R. sub. 4, R. sub. 5, R. sub. 6, R. sub. 7, R. sub. 8 and R. sub. 9 are the same or different and represent hydrogen, C. sub. 1 -C. sub. 6 alkyl, halogen, hydroxy, amino, cyano, nitro, trifluoromethyl, trifluoromethoxy, C. sub. 1 -C. sub. 6 alkoxy, --O. sub. 2 CR', --NHCOR', --COR', --SO. sub. m R', where R' is C. sub. 1 -C. sub. 6 alkyl and wherein m is 0, 1 or 2; or R. sub. 1, R. sub. 2, R. sub. 3, R4, R. sub. 5, R. sub. 6, R. sub. 7, R. sub. 8 and R. sub. 9 independently represent --CONR'R", or --NR'R" where R' and R" independently represent hydrogen or C. sub. 1 -C. sub. 6 alkyl; R. sub. 10 is hydrogen or C. sub. 1 -C. sub.

US Patent:

56889500, Nov 18, 1997

Filed:

Apr 23, 1996

Appl. No.:

8/636662

Inventors:

Xi Chen - New Haven CT
Jun Yuan - Clinton CT
Andrew Thurkauf - Danbury CT

Assignee:

Neurogen Corporation - Branford CT

International Classification:

C07D22106
C07D24140
C07D24136

US Classification:

544354

Abstract:

Disclosed are compounds of the formula: ##STR1## or the pharmaceutically acceptable acid addition salts thereof wherein: R1-R. sub. 4 represent organic or inorganic groups; A represents an alkylene group of 2 to 6 carbon atoms optionally substituted with one or more alkyl groups having from 1 to 4 carbon atoms; Y represents methylene, oxygen, sulfur, or NH; and X is either N, C or CH, which compounds are useful in the treatment of affective disorders such as schizophrenia, depression, Alzheimer's disease, movement disorders such as Parkinsonism and dystonia, and other disorders which respond to dopaminergic blockade such as substance abuse and obsessive compulsive disorders. Further, compounds of this invention may be useful in treating the extrapyramidal side effects associated with the use of conventional neuroleptic agents.