Xi Feng Chen

US Patent:

8163281, Apr 24, 2012

Filed:

Mar 3, 2010

Appl. No.:

12/716842

Inventors:

Yang Liu - Ann Arbor MI, US
Pan Zheng - Ann Arbor MI, US
Xincheng Zheng - Ann Arbor MI, US
Xi Chen - Woodland CA, US
Steve Kunkel - Ann Arbor MI, US

Assignee:

The Regents Of The University Of Michigan - Ann Arbor MI

International Classification:

A61K 39/395
A61K 39/00
A61K 38/16

US Classification:

4241301, 4241431, 4241841, 4241851, 514 212

Abstract:

The present technology provides methods and compositions for the treatment of tissue-damage related immune dysregulation by administering a composition comprising one or more of CD24; CD24 fragments, variants and derivatives, CD24Fc fusion proteins; HMBG1-binding proteins, binding proteins to HMBG1 Box B; antagonists of HMGB1, polyclonal, monoclonal, recombinant, chimeric, humanized scFv antibodies and antibody fragments to HMGB1 or fragments of HMGB1 and antibodies that bind and suppress the activity of HMGB1 Box B; Siglec 10 agonists such as anti-Siglec 10 antibodies; and combinations thereof to a patient.

US Patent:

20020132320, Sep 19, 2002

Filed:

Jan 10, 2001

Appl. No.:

09/758525

Inventors:

Peng Wang - Troy MI, US
Xi Chen - Norristown PA, US
Ziye Liu - Detroit MI, US
Wei Zhang - Detroit MI, US

International Classification:

C12P019/04
C12N009/10
C12N009/24
C12N015/00

US Classification:

435/193000, 435/200000, 435/320100, 435/325000, 435/101000

Abstract:

This invention relates to methods and compositions for the production of glycoconjugates. In particular, organisms are provided with at least one heterologous gene encoding an enzyme for regenerating a sugar nucleotide along with at least one glycosyltransterase. Such organisms are useful for the large-scale synthesis of glycoconjugates.

US Patent:

20020150968, Oct 17, 2002

Filed:

Jan 10, 2001

Appl. No.:

09/757846

Inventors:

Peng Wang - Troy MI, US
Xi Chen - Norristown PA, US

International Classification:

C12P033/20
C12P021/02
C12P019/20
C12N011/18

US Classification:

435/053000, 435/068100, 435/096000, 435/175000

Abstract:

This invention relates to methods and compositions for the in vitro production of glycoconjugates. In particular, a preferred production system is provided that comprises a solid support, at least one sugar nucleotide producing enzyme, at least one glycosyltransferase, at least one bioenergetic, and at least one acceptor. The sugar nucleotide producing enzyme(s) is preferably immobilized on the solid support. The glycosyltransferase may be co-immobilized on the solid support with the sugar nucleotide producing enzyme(s), or may be provided to the solid support in solution.

US Patent:

20120201819, Aug 9, 2012

Filed:

Mar 21, 2012

Appl. No.:

13/426392

Inventors:

Yang LIU - Ann Arbor MI, US
Pan ZHENG - Ann Arbor MI, US
Xi CHEN - Woodland CA, US
Steve KUNKEL - Ann Arbor MI, US
Xincheng ZHENG - Ann Arbor MI, US

Assignee:

THE REGENTS OF THE UNIVERSITY OF MICHIGAN - Ann Arbor MI

International Classification:

A61K 39/395
A61K 31/7008
A61P 29/00
A61K 31/715

US Classification:

4241341, 4241731, 514 54, 514 23

Abstract:

The present technology provides methods and compositions for the treatment of tissue-damage related immune dysregulation by administering a composition comprising one or more of CD24; CD24 fragments, variants and derivatives, CD24Fc fusion proteins; HMBG1-binding proteins, binding proteins to HMBG1 Box B; antagonists of HMGB1, polyclonal, monoclonal, recombinant, chimeric, humanized scFv antibodies and antibody fragments to HMGB1 or fragments of HMGB1 and antibodies that bind and suppress the activity of HMGB1 Box B; Siglec 10 agonists such as anti-Siglec 10 antibodies; and combinations thereof to a patient.

US Patent:

20220382899, Dec 1, 2022

Filed:

Mar 1, 2022

Appl. No.:

17/684184

Inventors:

- Mountain View CA, US
Xi Chen - Davis CA, US
Amrit Jassal - Morgan Hill CA, US
Daniel H. Jung - San Ramon CA, US
Gregory B. Neustaetter - Sunnyvale CA, US
Sean H. Puttergill - Sunnyvale CA, US
Ramakrishnan Sundararaj - Sunnyvale CA, US
Sanjay Vedanthan - Santa Clara CA, US
Chandra Yalangi - San Jose CA, US
Ramanathan Kavasseri - Fremont CA, US
Ravi Wijayaratne - San Jose CA, US
Shishir Sharma - Mountain View CA, US

Assignee:

Egnyte, Inc. - Mountain View CA

International Classification:

G06F 21/62
G06F 15/173
G06F 16/14
G06F 16/27
G06F 16/11
G06F 16/178
G06F 16/182
H04L 9/40

Abstract:

A method for providing access to objects associated with a particular client in a cloud storage system is disclosed. The method includes the steps of establishing a connection with a user, providing a client namespace associated with the client to the user, where the client namespace represents objects stored on the cloud storage system and objects stored on a private storage system apart from the cloud storage system, receiving a request from the user to access an object stored on the private storage system, and providing information to the user to facilitate access to the object stored on the private storage system by said user. Other systems and methods are also disclosed. Important advantages of the present invention are facilitated by separating the logic for user access (control plane) from the actual storage (Storage plane). Private file system access can still be managed from the cloud, while keeping the client data private.

US Patent:

20200372170, Nov 26, 2020

Filed:

Jun 11, 2020

Appl. No.:

16/899516

Inventors:

- Mountain View CA, US
Xi Chen - Davis CA, US
Amrit Jassal - Morgan Hill CA, US
Daniel H. Jung - San Ramon CA, US
Gregory B. Neustaetter - Sunnyvale CA, US
Sean H. Puttergill - Sunnyvale CA, US
Ramakrishnan Sundararaj - Sunnyvale CA, US
Sanjay Vedanthan - Santa Clara CA, US
Chandra Yalangi - San Jose CA, US
Ravi Wijayaratne - San Jose CA, US
Shishir Sharma - Mountain View CA, US

International Classification:

G06F 21/62
G06F 15/173
G06F 16/14
G06F 16/27
G06F 16/11
G06F 16/178
G06F 16/182
H04L 29/06

Abstract:

A method for providing access to objects associated with a particular client in a cloud storage system is disclosed. The method includes the steps of establishing a connection with a user, providing a client namespace associated with the client to the user, where the client namespace represents objects stored on the cloud storage system and objects stored on a private storage system apart from the cloud storage system, receiving a request from the user to access an object stored on the private storage system, and providing information to the user to facilitate access to the object stored on the private storage system by said user. Other systems and methods are also disclosed. Important advantages of the present invention are facilitated by separating the logic for user access (control plane) from the actual storage (Storage plane). Private file system access can still be managed from the cloud, while keeping the client data private.

US Patent:

20180247074, Aug 30, 2018

Filed:

Apr 30, 2018

Appl. No.:

15/967160

Inventors:

- Mountain View CA, US
Xi Chen - Davis CA, US
Amrit Jassal - Morgan Hill CA, US
Daniel H. Jung - San Ramon CA, US
Gregory B. Neustaetter - Sunnyvale CA, US
Sean H. Puttergill - Sunnyvale CA, US
Ramakrishnan Sundararaj - Sunnyvale CA, US
Sanjay Vedanthan - Santa Clara CA, US
Chandrasekhar Yalangi - San Jose CA, US
Ramanathan Kavasseri - Fremont CA, US
Shishir Sharma - Mountain View CA, US

International Classification:

G06F 21/62
G06F 15/173
G06F 17/30
H04L 29/06

Abstract:

A method for providing access to objects associated with a particular client in a cloud storage system is disclosed. The method includes the steps of establishing a connection with a user, providing a client namespace associated with the client to the user, where the client namespace represents objects stored on the cloud storage system and objects stored on a private storage system apart from the cloud storage system, receiving a request from the user to access an object stored on the private storage system, and providing information to the user to facilitate access to the object stored on the private storage system by said user. Other systems and methods are also disclosed. Important advantages of the present invention are facilitated by separating the logic for user access (control plane) from the actual storage (Storage plane). Private file system access can still be managed from the cloud, while keeping the client data private.

US Patent:

20160149888, May 26, 2016

Filed:

Jan 29, 2016

Appl. No.:

15/010415

Inventors:

- Mountain View CA, US
Xi Chen - Davis CA, US
Amrit Jassal - Morgan Hill CA, US
Daniel H. Jung - San Ramon CA, US
Gregory B. Neustaetter - Sunnyvale CA, US
Sean H. Puttergill - Sunnyvale CA, US
Ramakrishnan Sundararaj - Sunnyvale CA, US
Sanjay Vedanthan - Santa Clara CA, US
Chandra Yalangi - San Jose CA, US
Ramanathan Kavasseri - Fremont CA, US
Ravi Wijayaratne - San Jose CA, US
Shishir Sharma - Mountain View CA, US

International Classification:

H04L 29/06

Abstract:

A method for providing access to objects associated with a particular client in a cloud storage system is disclosed. The method includes the steps of establishing a connection with a user, providing a client namespace associated with the client to the user, where the client namespace represents objects stored on the cloud storage system and objects stored on a private storage system apart from the cloud storage system, receiving a request from the user to access an object stored on the private storage system, and providing information to the user to facilitate access to the object stored on the private storage system by said user. Other systems and methods are also disclosed. Important advantages of the present invention are facilitated by separating the logic for user access (control plane) from the actual storage (Storage plane). Private file system access can still be managed from the cloud, while keeping the client data private.