Xi I He from Overland Park, KS, age 62

view source

view source

view source

Antibodies That Bind Specifically To Phosphorylated Β-Catenin
view source
US Patent:

8106166, Jan 31, 2012
Filed:

Mar 17, 2008
Appl. No.:

12/077290
Inventors:

Xi He - Leawood KS, US
Tong Yin - Prairie Village KS, US
Qiang Tian - Seattle WA, US
Weiguo Tao - West Lafayette IN, US
Leroy Hood - Seattle WA, US
Linheng Li - Leawood KS, US
Assignee:

Stowers Institute for Medical Research - Kansas City MO
International Classification:

C07K 16/26
C07K 16/00
US Classification:

53038824, 5303881, 5303879, 5303871, 435810
Abstract:

The present invention relates to a purified molecules, including antibodies, that bind specifically to murine β-catenin phosphorylated at amino acid position Serineand to orthologs thereof, such as mammalian orthologs, including human orthologs. Methods of making and using such purified molecules are also provided. Kits containing such purified molecules are further provided.

Bmp Pathway Methods And Compositions
view source
US Patent:

20050271638, Dec 8, 2005
Filed:

Jun 3, 2004
Appl. No.:

10/860501
Inventors:

Linheng Li - Leawood KS, US
Xi He - Leawood KS, US
International Classification:

A61K048/00
C12N005/08
C12N015/86
US Classification:

424093210, 435456000, 435366000, 514044000
Abstract:

The present invention relates to mutant BMP intestinal stem cells (ISCs), with these mutant ISCs possessing an inactive Bmpr1a receptor in which BMP binding is substantially inhibited. The present invention relates to vectors which comprise mutant Bmpr1a nucleic acid sequences, whereby the vectors can be used to promote an increase in the number of ISCs in vivo or in vitro.

Pten/Akt Methods And Compositions Relating To Bmp
view source
US Patent:

20120115172, May 10, 2012
Filed:

Dec 15, 2011
Appl. No.:

13/327014
Inventors:

Xi HE - Leawood KS, US
Tong Yin - Prairie Village KS, US
Qiang Tian - Seattle WA, US
Weiguo Tao - West Lafayette IN, US
Leroy Hood - Seattle WA, US
Linheng Li - Leawood KS, US
International Classification:

G01N 33/566
US Classification:

435 792, 436501
Abstract:

The present invention relates to a purified molecules, including antibodies, that bind specifically to murine β-catenin phosphorylated at amino acid position Serineand to orthologs thereof, such as mammalian orthologs, including human orthologs. Methods of making and using such purified molecules are also provided. Kits containing such purified molecules are further provided.

Methods For Overcoming Wnt/Beta-Catenin Anti-Cancer Resistance In Leukemia Stem Cells
view source
US Patent:

20210113597, Apr 22, 2021
Filed:

Jun 26, 2020
Appl. No.:

16/914086
Inventors:

Linheng Li - Kansas City MO, US
John M. Perry - Olathe KS, US
Fang Tao - Overland Park KS, US
Xi C. He - Kansas City MO, US
Anuradha Roy - Kansas City MO, US
Scott J. Weir - Overland Park KS, US
Tara Lin - Mission Hills KS, US
International Classification:

A61K 31/704
A61K 39/395
C07K 16/28
A61P 35/02
Abstract:

The present disclosure provides, inter alia, methods for treating cancers including leukemia using low doses of an anthracycline such as doxorubicin.

Methods For Treating Chemoresistant Cancer-Initiating Cells
view source
US Patent:

20180207184, Jul 26, 2018
Filed:

Jul 28, 2016
Appl. No.:

15/745875
Inventors:

- Farmington CT, US
- Kansas City MO, US
- Lawrence KS, US
John M. PERRY - Kansas City MO, US
Gurusingham Sitta SITTAMPALAM - Fishers IN, US
Anuradha ROY - Kansas City MO, US
Xi C. HE - Kansas City MO, US
International Classification:

A61K 31/704
A61K 9/51
A61P 35/02
Abstract:

The disclosure provides methods of treating cancer by selectively inhibiting p-S-β-catenin, p-T-β-catenin, p-T-β-catenin, and/or p-S-β-catenin production and/or activity. Such methods also and/or limit cancer-initiating cells.

Methods, Kits, And Compositions For Stem Cell Self-Renewal
view source
US Patent:

20140255359, Sep 11, 2014
Filed:

Oct 17, 2012
Appl. No.:

14/352410
Inventors:

- Kansas City MO, US
Linheng Li - Leawood KS, US
Aparna Venkatraman - Prairie Village KS, US
Xi He - Leawood KS, US
International Classification:

C12N 5/0789
A61K 35/28
US Classification:

424 937, 435377, 435372
Abstract:

Methods and kits for expanding a stem cell population, particularly a hematopoietic stem cell population, in the presence of a DNA methyltransferase modulator and a Wnt pathway modulator are disclosed.