Xiang Li

US Patent:

7235654, Jun 26, 2007

Filed:

Dec 8, 2003

Appl. No.:

10/730614

Inventors:

Jun Li - Danbury CT, US
Xiang Li - Danbury CT, US
Jianfei Yang - Sandy Hook CT, US

Assignee:

Boehringer Ingelheim Pharmaceuticals, Inc. - Ridgefield CT

International Classification:

C07H 21/02
C07H 21/04

US Classification:

536 245, 536 231, 536 243, 536 2433

Abstract:

A method for modulating NF-κB dependent gene transcription in a cell comprised of modulating IKKα protein activity in the cell. The present invention also provides siRNA compositions and methods thereof for modulating NF-κB dependent gene transcription.

US Patent:

7368258, May 6, 2008

Filed:

Jun 6, 2006

Appl. No.:

11/447089

Inventors:

Charles Bieberich - Brookville MD, US
Xiang Li - Baltimore MD, US

Assignee:

University of Maryland, Baltimore County - Baltimore MD

International Classification:

C12Q 1/50

US Classification:

435 17

Abstract:

The present invention relates to apparatus and methods for separating and detecting enzyme substrates using separation gels. For example, the apparatus and methods can be used to separate and detect kinase substrates for further analysis. The apparatus and methods can also be used to detect enzyme inhibitors, such as kinase inhibitors.

US Patent:

7666617, Feb 23, 2010

Filed:

Mar 27, 2008

Appl. No.:

12/078157

Inventors:

Charles Bieberich - Brookeville MD, US
Xiang Li - Baltimore MD, US

Assignee:

University of Maryland, Baltimore County - Baltimore MD

International Classification:

C12Q 1/50

US Classification:

435 17

Abstract:

The present invention relates to apparatus and methods for separating and detecting enzyme substrates using separation gels. For example, the apparatus and methods can be used to separate and detect kinase substrates for further analysis. The apparatus and methods can also be used to detect enzyme inhibitors, such as kinase inhibitors.

US Patent:

7838268, Nov 23, 2010

Filed:

Apr 26, 2007

Appl. No.:

11/740438

Inventors:

Jun Li - Danbury CT, US
Xiang Li - Danbury CT, US
Jianfei Yang - Sandy Hook CT, US
Kenneth Marcu - Stony Brook NY, US

Assignee:

Boehringer Ingelheim International GmbH - Ingelheim am Rhein

International Classification:

C12Q 1/68
C12P 19/34
C12N 5/00
C12N 5/02
C07H 21/04

US Classification:

435 911, 435 6, 435325, 435375, 536 245

Abstract:

A method for modulating NF-κB dependent gene transcription in a cell comprised of modulating IKKα protein activity in the cell. The present invention also provides siRNA compositions and methods thereof for modulating NF-κB dependent gene transcription.

US Patent:

7951933, May 31, 2011

Filed:

Feb 10, 2005

Appl. No.:

11/056106

Inventors:

Jun Li - Danbury CT, US
Xiang Li - Danbury CT, US
Baerbel LoSacco - New Milford CT, US
Zhenhao Qi - Sandy Hook CT, US

Assignee:

Boehringer Ingelheim Pharmaceutical, Inc. - Ridgefield CT

International Classification:

C07H 21/02
C07H 21/04
C12Q 1/68
C12P 19/34
C12N 5/00
C12N 5/02

US Classification:

536 245, 536 231, 536 243, 536 2433, 435 6, 435 911, 435325, 435375

Abstract:

The invention provides for a substantially purified polypeptide referred to herein as CD38JL that is a CD38 splice variant comprised of the polypeptide of SEQ ID NO: 1 or a fragment thereof. The invention also provides methods for treating preventing and diagnosing disorders associated with expression of CD38JL.

US Patent:

8088915, Jan 3, 2012

Filed:

Oct 13, 2010

Appl. No.:

12/903600

Inventors:

Jun Li - Danbury CT, US
Xiang Li - Danbury CT, US
Jianfei Yang - Sandy Hook CT, US
Kenneth B. Marcu - Stony Brook NY, US

Assignee:

Boehringer Ingelheim Pharmaceuticals Inc. - Ridgefield CT

International Classification:

C07H 21/02
C07H 21/04

US Classification:

536 245, 536 231, 536 243, 536 2433

Abstract:

A method for modulating NF-κB dependent gene transcription in a cell comprised of modulating IKKα protein activity in the cell. The present invention also provides siRNA compositions and methods thereof for modulating NF-κB dependent gene transcription.

US Patent:

8093266, Jan 10, 2012

Filed:

Jan 2, 2008

Appl. No.:

12/521817

Inventors:

Georg Dahmann - Attenweiler, DE
Eugene Richard Hickey - Danbury CT, US
Xiang Li - Danbury CT, US
Wang Mao - Milford CT, US
Daniel R. Marshall - Sandy Hook CT, US
Tina M. Morwick - New Milford CT, US
Robert Sibley - North Haven CT, US
Roger John Snow - Danbury CT, US
Ronald J. Sorcek - Bethel CT, US
Frank Wu - Ridgefield CT, US
Erick Richard Roush Young - Danbury CT, US

Assignee:

Boehringer Ingelheim International GmbH - Ingelheim am Rhein

International Classification:

A61K 31/472
A61K 31/4365
A61K 31/17
C07D 217/22
C07D 211/34
C07C 233/64
C07C 275/28

US Classification:

514310, 514302, 5142395, 514596, 514617, 546143, 546226, 564161, 564192

Abstract:

Substituted amide and urea derivatives useful as inhibitors of Rho kinase are described, which inhibitors can be useful in the treatment of various disorders such as cardiovascular diseases, cancer, neurological diseases, renal diseases, bronchial asthma, erectile dysfunction and glaucoma.

US Patent:

8370127, Feb 5, 2013

Filed:

Jun 16, 2006

Appl. No.:

11/454694

Inventors:

Xiang Li - White Plains NY, US
David Lubensky - Brookfield CT, US
Osamuyimen Thompson Stewart - Piscataway NJ, US

Assignee:

Nuance Communications, Inc. - Burlington MA

International Classification:

G06F 17/27
G10L 15/00
G10L 11/00
H04M 1/64

US Classification:

704 9, 704231, 704257, 704270, 379 8802

Abstract:

A method of processing limited natural language data to automatically develop an optimal feature set, bypassing the standard Wizard of OZ (WOZ) approach. Natural language understanding models process existing data from other domains, such as the Internet, for domain-specific adaptation through the use of an optimal feature set. When the optimal feature set is passed on to any engine, the optimal feature set produces robust models that can be used for natural language call routing.