Xiangji Chen

US Patent:

20130261715, Oct 3, 2013

Filed:

Mar 7, 2013

Appl. No.:

13/789602

Inventors:

Kimberly A. Chaffin - Woodbury MN, US
Matthew Jolly - Minneapolis MN, US
Darrel F. Untereker - Oak Grove MN, US
Adam J. Buckalew - Medina MN, US
Xiangji Chen - Woodbury MN, US
Thomas P. Grailer - Ramsey MN, US
Julie Alkatout - Minneapolis MN, US

International Classification:

A61N 1/05

US Classification:

607116, 525389

Abstract:

Medical leads, such as medical electrical leads and medical neurological leads, that include a polymeric material that includes a silicone-urethane-containing polymer having improved hydrolytic stability.

US Patent:

20210115182, Apr 22, 2021

Filed:

Dec 4, 2020

Appl. No.:

17/112344

Inventors:

- Minneapolis MN, US
Xiangji Chen - Plymouth MN, US
Matthew Jolly - Minneapolis MN, US
SuPing Lyu - Maple Grove MN, US
Peter L. Thor - Arden Hills MN, US
Darrel F. Untereker - Cedar MN, US
Zhaoxu Wang - New Brighton MN, US

International Classification:

C08G 18/62
A61B 5/00
A61L 31/06
A61L 31/16
A61N 1/05
C08G 18/10
C08G 18/32
C08G 18/65
C08G 18/76
A61B 5/145

Abstract:

A modified polyisobutylene-based polymer, method of making, and a medical device that includes such polymer, wherein the modified polyisobutylene-based polymer includes urethane, urea, or urethane-urea groups, hard segments, and soft segments, wherein the soft segments comprise phenoxy-containing polyisobutylene residues, and the hard segments include diisocyanate residues and optionally chain extender residues.

US Patent:

20200354514, Nov 12, 2020

Filed:

Jul 23, 2020

Appl. No.:

16/936858

Inventors:

- Minneapolis MN, US
FATIMA BUEVICH - HIGHLAND PARK NJ, US
XIANGJI CHEN - PLYMOUTH MN, US
SUPING LYU - MAPLE GROVE MN, US

Assignee:

MEDTRONIC, INC. - Minneapolis MN

International Classification:

C08G 63/81
C08G 63/685

Abstract:

A method for preparing tyrosine derived polyarylates includes combining a desaminotyrosyl-tyrosine ethyl ester, a desaminotyrosyl-tyrosine benzylester, succinic acid and a catalyst in a flask to produce a first mixture. Methylene chloride is added to the first mixture to produce a first suspension. Diisopropylcarbodiimide (DIPC) is added to the first mixture to produce a first solution. The first solution is added to a non-solvent to produce a precipitate. The precipitate is dissolved in methylene chloride to form a polymer solution. The polymer solution is blended with a slurry to produce polymer shreds. The polymer shreds are blended with a second slurry to produce a tyrosine derived polyarylate.

US Patent:

20190292302, Sep 26, 2019

Filed:

Mar 20, 2019

Appl. No.:

16/359079

Inventors:

- Minneapolis MN, US
Xiangji CHEN - Plymouth MN, US
Matthew JOLLY - Minneapolis MN, US
SuPing LYU - Maple Grove MN, US
Peter L. THOR - Arden Hills MN, US
Darrel F. UNTEREKER - Cedar MN, US
Zhaoxu WANG - New Brighton MN, US

International Classification:

C08G 18/62
C08G 18/76
C08G 18/32
C08G 18/65
C08G 18/10
A61L 31/16
A61L 31/06
A61N 1/05

Abstract:

A modified polyisobutylene-based polymer, method of making, and a medical device that includes such polymer, wherein the modified polyisobutylene-based polymer includes urethane, urea, or urethane-urea groups, hard segments, and soft segments, wherein the soft segments comprise phenoxy-containing polyisobutylene residues, and the hard segments include diisocyanate residues and optionally chain extender residues.

US Patent:

20190292327, Sep 26, 2019

Filed:

Mar 20, 2019

Appl. No.:

16/358939

Inventors:

- Minneapolis MN, US
Xiangji CHEN - Plymouth MN, US
Matthew JOLLY - Minneapolis MN, US
SuPing LYU - Maple Grove MN, US
Peter L. THOR - Arden Hills MN, US
Darrel F. UNTEREKER - Cedar MN, US
Zhaoxu WANG - New Brighton MN, US

International Classification:

C08G 81/02
A61L 31/06
A61L 31/16
A61L 31/04
A61N 1/05

Abstract:

A poly(ether-carbonate)-based polymer and a medical device that includes such polymer, wherein the poly(ether-carbonate)-based polymer includes urethane, urea, or urethane-urea groups, hard segments, and soft segments, wherein the soft segments include poly(ether-carbonate) residues and at least one of polyisobutylene (PIB) residues and hydrogenated polybutadiene residues, and the hard segments include diisocyanate residues and optionally chain extender residues.

US Patent:

20190111186, Apr 18, 2019

Filed:

Mar 2, 2017

Appl. No.:

16/091040

Inventors:

- Mounds View MN, US
XiangJi CHEN - Fridley MN, US
Jing CHEN - Ningbo, Zhejiang, CN
Haining NA - Ningbo, Zhejiang, CN
Jin ZHU - Ningbo, Zhejiang, CN

International Classification:

A61L 29/04
C08L 75/04
A61M 25/00
A61L 29/14

Abstract:

A medical device, a method for preparation thereof, and use thereof are provided. The medical device comprises a thermoplastic elastomer that is composed of soft segments and hard segments. The method for preparing a medical device comprising a thermoplastic elastomer, comprises forming the thermoplastic elastomer into tubing or other shapes via extrusion, molding, or coating, assembling the tubing or other shapes with other parts including: cables, coils, coated cables, or coated coils, and bonding the tubing, cables, or coils with other components including: other tubing components, cables, coils, sleeves, electrical pulse generator, defibrillation shock generator, electrodes, sensors, or drug release components. The medical device is used for correcting cardiac rhythm, defibrillating, assisting hearts, sensing, stimulating neurological systems, gastrointestinal system, or skeletomuscular tissues or organs.

US Patent:

20190112411, Apr 18, 2019

Filed:

Mar 2, 2017

Appl. No.:

16/091045

Inventors:

- NINGBO, Zhejiang, CN
Haining NA - NINGBO, Zhejiang, CN
Jin ZHU - NINGBO, Zhejiang, CN
Suping LYU - Mounds View MN, US
XiangJi CHEN - Fridley MN, US

International Classification:

C08G 18/12
C08G 18/48
C08G 18/62
C08G 18/73
C08G 18/75
C08G 18/76
C08G 18/08

Abstract:

Disclosed is a segmented thermoplastic elastomer that can be a polyurethane, polyurea, or polyurethane-urea comprising soft segments and hard segments, wherein the soft segments are made of polyolefin diols or polyolefin diamine that may have 0 to 1000 carbon atoms in the main chain, wherein each carbon atom in the main chain may have 0 to 2 side chains and each side chain may have 0 to 30 carbon atoms, the hard segment is made of a diisocyante and a chain extender, the hard segments make up 10-60% of the elastomer and the soft segments make up the rest, the number-average molecular weight of the elastomer is 5×10-1000×10g/mol, the ultimate elongation of the elastomer is 100-1000%, the Young's modulus is 1 to 3,000 MPa, and the ultimate tensile strength is 10-100 MPa. Also disclosed are a method for preparing the segmented thermoplastic elastomer and use of segmented thermoplastic elastomer.

US Patent:

20180354892, Dec 13, 2018

Filed:

May 7, 2018

Appl. No.:

15/972819

Inventors:

- Monmouth Junction NJ, US
Fatima Buevich - Highland Park NJ, US
Xiangji Chen - Plymouth MN, US
Suping Lyu - Maple Grove MN, US

Assignee:

TYRX, Inc. - Monmouth Junction NJ

International Classification:

C07C 231/02
C07C 231/22
C07C 235/34

Abstract:

A method for preparing diphenol compounds includes adding a hydroxyphenyl carboxylic acid, a tyrosine ethyl ester, hydroxybenzotriazole hydrate and a solvent and stirring to produce a first solution. EDCl HCl is added to the first solution to produce a first mixture. Ethyl acetate is added to the first mixture to produce a second mixture. The second mixture is added to sodium chloride to produce a third mixture having layer separation. An aqueous layer is removed from the third mixture. The third mixture is extracted with reagents after the aqueous layer has been removed from the third mixture to produce a fourth mixture. Magnesium sulfate is added to the fourth mixture to produce a fifth mixture. The fifth mixture is filtered to produce filtrate. The filtrate is concentrated. Crystallization of the concentrated filtrate is induced. Methylene chloride is added to the crystallized filtrate to produce a solid product.