Xiao M Zhou

US Patent:

6395552, May 28, 2002

Filed:

Apr 27, 1999

Appl. No.:

09/300634

Inventors:

Ramesh B. Borade - San Jose CA
Damodara Poojary - Cupertino CA
Xiao Ping Zhou - Sunnyvale CA

Assignee:

Symyx Technologies - Santa Clara CA

International Classification:

G01N 3110

US Classification:

436 37, 427265, 502 1, 502 2, 502 84, 502102, 502103, 502104, 502150

Abstract:

The present invention discloses an apparatus and method for rapid synthesis and analysis of members of a combinatorial library. The apparatus includes a plurality of vessels for containing individual library members and a fluid handling system that apportions a test fluid about equally between each of the vessels. This allows for simultaneous screening of library members by detecting changes in test fluid following contact with individual library members. Fluid flow through each of the vessels is controlled using passive flow restrictors or active flow controllers to ensure that each library member contacts approximately the same amount of test fluid per unit time. The disclosed apparatus and method is especially useful for making inorganic oxide mixtures and for screening the mixtures based on their ability to catalyze the conversion of fluid reactants.

US Patent:

6410332, Jun 25, 2002

Filed:

Sep 8, 1998

Appl. No.:

09/149586

Inventors:

Peter J. Desrosiers - Cupertino CA
Xiao Ping Zhou - Sunnyvale CA

Assignee:

Symyx Technologies, Inc. - Santa Clara CA

International Classification:

G01N 3110

US Classification:

436 37, 436164, 436167, 436178, 436181, 422 681, 422 56, 422 88

Abstract:

Methods and devices for rapidly analyzing groups of reactions are disclosed. The method includes the steps of contacting a fluid sample from one of the reaction mixtures with a sorbent, trapping at least one component of the fluid sample on the sorbent, and detecting the at least one component of the fluid sample trapped on the sorbent. The contacting step, the trapping step, and the detecting step are carried out at least once for each of the reaction mixtures in rapid serial or parallel fashion. The present invention is useful for screening combinatorial libraries, especially libraries of catalysts made through parallel synthesis, but the disclosed methods and devices can be used to analyze a broad spectrum of chemical transformations.

US Patent:

6495376, Dec 17, 2002

Filed:

Feb 18, 1999

Appl. No.:

09/252404

Inventors:

Kun Ping Lu - Newton MA
Xiao Zhen Zhou - Newton MA

Assignee:

Beth Israel Deaconess Medical Center - Boston MA

International Classification:

G01N 33566

US Classification:

436501, 435 4, 435 71, 435 76, 435 772, 435 793, 435 794, 435 795, 530300, 530350

Abstract:

The invention relates to methods and compositions of WW-domains as phosphoserine and phosphothreonine binding modules. The WW-domain containing polypeptides of the invention can be used, for example, to regulate cell growth; to treat neurodegenerative diseases; to screen for substances that modulated interactions between WW-domain containing polypeptides and phosphorylated ligands; as drug targeting vehicles; to direct protein degradation; and in the treatment of certain diseases or conditions characterized by aberrant WW-domain containing polypeptides or their ligands.

US Patent:

6667009, Dec 23, 2003

Filed:

Apr 20, 2000

Appl. No.:

09/553244

Inventors:

Peter J. Desrosiers - Cupertino CA
Xiao Ping Zhou - Sunnyvale CA

Assignee:

Symyx Technologies, Inc. - Santa Clara CA

International Classification:

B01L 1100

US Classification:

422101, 422 681, 422 99, 422102, 422129, 422131, 436 37, 436174, 436177, 436178

Abstract:

Methods and devices for rapidly analyzing groups of reactions are disclosed. The method includes the steps of contacting a fluid sample from one of the reaction mixtures with a sorbent, trapping at least one component of the fluid sample on the sorbent, and detecting the at least one component of the fluid sample trapped on the sorbent. The contacting step, the trapping step, and the detecting step are carried out at least once for each of the reaction mixtures in rapid serial or parallel fashion. The present invention is useful for screening combinatorial libraries, especially libraries of catalysts made through parallel synthesis, but the disclosed methods and devices can be used to analyze a broad spectrum of chemical transformations.

US Patent:

6869799, Mar 22, 2005

Filed:

Jun 29, 2000

Appl. No.:

09/607535

Inventors:

Shenheng Guan - San Jose CA, US
Lynn Van Erden - Livermore CA, US
Robert C. Haushalter - Los Gatos CA, US
Xiao Ping Zhou - Sunnyvale CA, US
Xuejun Jason Wang - Fremont CA, US
Ravi Srinivasan - Mountain View CA, US

Assignee:

Symyx Technologies, Inc. - Santa Clara CA

International Classification:

C02N031/10

US Classification:

436 37, 422 80, 422 83, 422129, 422130, 436159, 436172, 436174, 436180

Abstract:

The present invention discloses an apparatus and method for rapid analysis of members of a combinatorial library. The apparatus includes a plurality of vessels for containing individual library members and a fluid handling system that apportions a test fluid about equally between each of the vessels. This allows for simultaneous screening of library members by detecting changes in test fluid following contact with individual library members. Fluid flow through each of the vessels is controlled using passive flow restrictors or active flow controllers to ensure that each library member contacts approximately the same amount of test fluid per unit time. The disclosed apparatus is especially useful for screening library members based on their ability to catalyze the conversion of fluid reactants.

US Patent:

6933409, Aug 23, 2005

Filed:

May 15, 2000

Appl. No.:

09/571567

Inventors:

Damodara M. Poojary - Cupertino CA, US
Ramesh Borade - San Jose CA, US
Alfred Hagemeyer - Sunnyvale CA, US
Xiao Ping Zhou - Sunnyvale CA, US
Christopher E. Dube - Arlington MA, US
Ulrich Notheis - Dormagen, DE
Ralph Armbrust - Leverkusen, DE
Christian Rasp - Bergisch Gladbach, DE
David M. Lowe - Mountain View CA, US

Assignee:

Symyx Technologies, Inc. - Santa Clara CA
Bayer AG - Leverkusen

International Classification:

C07C209/00

US Classification:

564408, 564395

Abstract:

Noble metal/reducible metal oxide catalysts effective for the direct amination of aromatic hydrocarbons and heterocyclic analogs thereof are disclosed. In one embodiment, the cataloxidant comprises a noble metal selected from Pd, Rh, Ir and/or Ru and a reducible metal oxide. In another embodiment, the cataloxidant comprises a noble metal and a reducible oxide of a metal selected from Ni, Mn, V, Ce, Th, Pr, Te, Re, Co, Fe, Cu and/or Bi. A preferred cataloxidant comprises one or more noble metals selected from Pd, Rh, Ir and/or Ru, in combination with nickel oxide and/or manganese oxide. In preferred applications, benzene can be aminated in the presence of the cataloxidants to form aniline. A benzene conversion of at least 5% is achieved, with more than 90% selectivity for aniline. Significantly, the cataloxidant can be regenerated without a substantial loss of performance.

US Patent:

7241424, Jul 10, 2007

Filed:

Feb 8, 2002

Appl. No.:

10/071546

Inventors:

Shenheng Guan - Palo Alto CA, US
Lynn Van Erden - Livermore CA, US
Robert C. Haushalter - Los Gatos CA, US
Xiao Ping Zhou - Sunnyvale CA, US
Xuejun Jason Wang - Fremont CA, US
Ravi Srinivasan - Mountain View CA, US

Assignee:

Symyx Technologies, Inc. - Santa Clara CA

International Classification:

B01J 19/00

US Classification:

422130, 422102, 422129, 422131, 436 37, 436179, 436180

Abstract:

The present invention discloses an apparatus and method for rapid analysis of members of a combinatorial library. The apparatus includes a plurality of vessels for containing individual library members and a fluid handling system that apportions a test fluid about equally between each of the vessels. This allows for simultaneous screening of library members by detecting changes in test fluid following contact with individual library members. Fluid flow through each of the vessels is controlled using passive flow restrictors or active flow controllers to ensure that each library member contacts approximately the same amount of test fluid per unit time. The disclosed apparatus is especially useful for screening library members based on their ability to catalyze the conversion of fluid reactants.

US Patent:

8129131, Mar 6, 2012

Filed:

Jul 18, 2008

Appl. No.:

12/218838

Inventors:

Kun Ping Lu - Newton MA, US
Xiao Zhen Zhou - Newton MA, US
Gerburg Wulf - Cambridge MA, US

Assignee:

Beth Israel Deaconess Medical Center - Boston MA

International Classification:

G01N 33/53

US Classification:

435 723

Abstract:

Methods for the use of Pin1 as a marker of abnormal cell growth are disclosed. In one embodiment, the method includes detecting a level of Pin1 to stage an abnormal cell growth, such as breast or prostate cancer. In another embodiment, the method includes evaluating the efficacy of a treatment of an abnormal cell growth, such as cancer, by monitoring the levels of Pin1. In another embodiment, the method includes evaluating the extent of metastasis of abnormal cell growth, such as cancer. The levels of Pin1 can be protein levels or nucleic acid levels.