Xiao A Zhou

US Patent:

6495376, Dec 17, 2002

Filed:

Feb 18, 1999

Appl. No.:

09/252404

Inventors:

Kun Ping Lu - Newton MA
Xiao Zhen Zhou - Newton MA

Assignee:

Beth Israel Deaconess Medical Center - Boston MA

International Classification:

G01N 33566

US Classification:

436501, 435 4, 435 71, 435 76, 435 772, 435 793, 435 794, 435 795, 530300, 530350

Abstract:

The invention relates to methods and compositions of WW-domains as phosphoserine and phosphothreonine binding modules. The WW-domain containing polypeptides of the invention can be used, for example, to regulate cell growth; to treat neurodegenerative diseases; to screen for substances that modulated interactions between WW-domain containing polypeptides and phosphorylated ligands; as drug targeting vehicles; to direct protein degradation; and in the treatment of certain diseases or conditions characterized by aberrant WW-domain containing polypeptides or their ligands.

US Patent:

8129131, Mar 6, 2012

Filed:

Jul 18, 2008

Appl. No.:

12/218838

Inventors:

Kun Ping Lu - Newton MA, US
Xiao Zhen Zhou - Newton MA, US
Gerburg Wulf - Cambridge MA, US

Assignee:

Beth Israel Deaconess Medical Center - Boston MA

International Classification:

G01N 33/53

US Classification:

435 723

Abstract:

Methods for the use of Pin1 as a marker of abnormal cell growth are disclosed. In one embodiment, the method includes detecting a level of Pin1 to stage an abnormal cell growth, such as breast or prostate cancer. In another embodiment, the method includes evaluating the efficacy of a treatment of an abnormal cell growth, such as cancer, by monitoring the levels of Pin1. In another embodiment, the method includes evaluating the extent of metastasis of abnormal cell growth, such as cancer. The levels of Pin1 can be protein levels or nucleic acid levels.

US Patent:

20020025521, Feb 28, 2002

Filed:

Nov 29, 2000

Appl. No.:

09/726464

Inventors:

Kun Lu - Newton MA, US
Gerburg Wulf - Cambridge MA, US
Xiao Zhou - Newton MA, US

International Classification:

C12Q001/68
G01N033/574

US Classification:

435/006000, 435/007230

Abstract:

Methods for the use of Pin1 as a marker of abnormal cell growth are disclosed. In one embodiment, the method includes detecting a level of Pin1 to stage an abnormal cell growth, such as breast or prostate cancer. In another embodiment, the method includes evaluating the efficacy of a treatment of an abnormal cell growth, such as cancer, by monitoring the levels of Pin1. In another embodiment, the method includes evaluating the extent of metastasis of abnormal cell growth, such as cancer. The levels of Pin1 can be protein levels or nucleic acid levels.

US Patent:

20030049672, Mar 13, 2003

Filed:

Sep 26, 2002

Appl. No.:

10/256865

Inventors:

Kun Lu - Newton MA, US
Xiao Zhou - Newton MA, US

Assignee:

Beth Israel Deaconess Medical Center

International Classification:

C12Q001/70
C12Q001/68
G01N033/53

US Classification:

435/006000, 435/005000, 435/007100

Abstract:

The invention relates to methods and compositions of WW-domains as phosphoserine and phosphothreonine binding modules. The WW-domain containing polypeptides of the invention can be used, for example, to regulate cell growth; to treat neurodegenerative diseases; to screen for substances that modulated interactions between WW-domain containing polypeptides and phosphorylated ligands; as drug targeting vehicles; to direct protein degradation; and in the treatment of certain diseases or conditions characterized by aberrant WW-domain containing polypeptides or their ligands.

US Patent:

20040142357, Jul 22, 2004

Filed:

Nov 10, 2003

Appl. No.:

10/705531

Inventors:

Kun Lu - Newton MA, US
Xiao Zhou - Newton MA, US

Assignee:

Beth Israel Deaconess Medical Center

International Classification:

C12Q001/68
C07H021/04
C12N009/99

US Classification:

435/006000, 435/069200, 435/184000, 435/320100, 435/325000, 530/388260, 536/023200

Abstract:

The present invention provides molecules including Pin2 and telomerase binding polypeptides, polynucleotides encoding such polypeptides, and antibodies specifically immunoreactive to said polypeptides. The invention also provides methods for screening agents which modulate the function or expression of said Pin2 and telomerase binding polypeptides. Methods are provided for disease diagnosis and treatment using said agents, said antibodies and oligonucleotides derived from the above polynucleotides.

US Patent:

20050186643, Aug 25, 2005

Filed:

Oct 9, 2003

Appl. No.:

10/683880

Inventors:

Kun Lu - Newton MA, US
Gerburg Wulf - Cambridge MA, US
Xiao Zhou - Newton MA, US

International Classification:

G01N033/574

US Classification:

435007230

Abstract:

Methods for the use of Pin1 as a marker of abnormal cell growth are disclosed. In one embodiment, the method includes detecting a level of Pin1 to stage an abnormal cell growth, such as breast or prostate cancer. In another embodiment, the method includes evaluating the efficacy of a treatment of an abnormal cell growth, such as cancer, by monitoring the levels of Pin1. In another embodiment, the method includes evaluating the extent of metastasis of abnormal cell growth, such as cancer. The levels of Pin1 can be protein levels or nucleic acid levels.

US Patent:

20050282740, Dec 22, 2005

Filed:

Dec 21, 2004

Appl. No.:

11/022308

Inventors:

Kun Lu - Newton MA, US
Xiao Zhou - Newton MA, US

International Classification:

A61K038/17

US Classification:

514007000

Abstract:

The invention relates to methods and compositions of WW-domains as phosphoserine and phosphothreonine binding modules. The WW-domain containing polypeptides of the invention can be used, for example, to regulate cell growth; to treat neurodegenerative diseases; to screen for substances that modulated interactions between WW-domain containing polypeptides and phosphorylated ligands; as drug targeting vehicles; to direct protein degradation; and in the treatment of certain diseases or conditions characterized by aberrant WW-domain containing polypeptides or their ligands.

US Patent:

20080058276, Mar 6, 2008

Filed:

Jan 16, 2007

Appl. No.:

11/623672

Inventors:

Kun LU - Newton MA, US
Linda NICHOLSON - Ithaca NY, US
Lucia PASTORINO - Boston MA, US
Xiao ZHOU - Newton MA, US
Soumya DE - Ithaca NY, US

Assignee:

CORNELL RESEARCH FOUNDATION, INC. - Ithaca NY
BETH ISRAEL DEACONESS MEDICAL CENTER - Boston MA

International Classification:

A61K 31/70
A61P 25/28
C12N 5/06
C12Q 1/02
G01N 33/00

US Classification:

514044000, 435029000, 435375000, 436086000

Abstract:

The present invention is directed to inhibiting amyloidogenic processing of amyloid precursor protein, and/or inhibiting production of amyloid beta peptides. These methods can involve accelerating cis/trans isomerization of amyloid precursor protein at a phosphorylated serine/threonine-proline motif and/or contacting a cell with a compound that mimics the cis conformation of a phosphorylated serine/threonine-proline motif of an amyloid precursor protein. The present invention also relates to treating and/or preventing in a subject a degenerative neurological disease characterized by amyloidogenic processing of amyloid precursor protein and/or overproduction of amyloid beta peptide. This method involves administering an agent that accelerates cis/trans isomerization of amyloid precursor protein at a phosphorylated serine/threonine-proline motif and/or inhibits production of amyloid β peptides. Methods of screening for therapeutic agents effective in treating and/or preventing such diseases, methods of screening for biological molecules involved in the amyloidogenic pathway, and compounds that mimic the cis conformation of a phosphorylated serine/threonine-proline motif of an amyloid precursor protein are also disclosed.