Xiao L Zhou

US Patent:

7241424, Jul 10, 2007

Filed:

Feb 8, 2002

Appl. No.:

10/071546

Inventors:

Shenheng Guan - Palo Alto CA, US
Lynn Van Erden - Livermore CA, US
Robert C. Haushalter - Los Gatos CA, US
Xiao Ping Zhou - Sunnyvale CA, US
Xuejun Jason Wang - Fremont CA, US
Ravi Srinivasan - Mountain View CA, US

Assignee:

Symyx Technologies, Inc. - Santa Clara CA

International Classification:

B01J 19/00

US Classification:

422130, 422102, 422129, 422131, 436 37, 436179, 436180

Abstract:

The present invention discloses an apparatus and method for rapid analysis of members of a combinatorial library. The apparatus includes a plurality of vessels for containing individual library members and a fluid handling system that apportions a test fluid about equally between each of the vessels. This allows for simultaneous screening of library members by detecting changes in test fluid following contact with individual library members. Fluid flow through each of the vessels is controlled using passive flow restrictors or active flow controllers to ensure that each library member contacts approximately the same amount of test fluid per unit time. The disclosed apparatus is especially useful for screening library members based on their ability to catalyze the conversion of fluid reactants.