Providence Medical GroupProvidence Health & Services Regional Pathology Center 4400 NE Halsey St BLDG 3, Portland, OR 97213 5036506816 (phone), 5038937795 (fax)
Education:
Medical School Hunan Med Univ, Changsha City, Hunan, China Graduated: 1983
Languages:
English
Description:
Dr. Cai graduated from the Hunan Med Univ, Changsha City, Hunan, China in 1983. He works in Portland, OR and specializes in Anatomic Pathology & Clinical Pathology. Dr. Cai is affiliated with Providence Milwaukie Hospital, Providence Newberg Medical Center and Providence Saint Vincent Medical Center.
Doctor of Philosophy Doctor of Medicine Hospital of the University of Pennsylvania - Fellowship - Surgical Pathology - Gastrointestinal Bernard Mitchell Hospital-University of Chicago Hospitals - Residency - Pathology
Board certifications:
American Board of Pathology Certification in Anatomic Pathology (Pathology)
Us Patents
Anti-Preproprotein And Anti-Preprotein Antibodies As Immunohistochemical Markers
XIAOHONG CAI - PORTLAND OR, US THOMAS CAI - PORTLAND OR, US
International Classification:
G01N 33/53 G01N 33/566 C07K 16/00
US Classification:
435 79, 436501, 5303879
Abstract:
It is disclosed herein that antibodies specific for preproproteins or preproteins, which are synthesized by certain types of cells or tissues, can be used in immunohistochemistry assays to discriminate between the intracellular component of the protein (including the preproprotein, preprotein and/or proprotein forms of the protein) from the secreted component of the same protein. Accordingly, provided herein is an immunohistochemical method for specific detection of the intracellular form of a protein in a biological sample using an antibody specific for the preproprotein or preprotein form of the protein. In particular examples, the protein is albumin or an immunoglobulin light chain. Also disclosed herein are preproprotein-specific ore preprotein-specific antibodies that can be used to detect specific cell types, tissue lesions or other pathological foci and metastases by IHC. In particular, antibodies that specifically bind human preproalbumin, but do not bind the secreted form of albumin are disclosed.
Youtube
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