Xiaoling Li from Brookline, MA

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Work:

Postdoctoral Researcher

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Cholesterol-Regulating Complex Of Sirt1 And Lxr And Methods Of Use
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US Patent:

20100240029, Sep 23, 2010
Filed:

Jun 6, 2007
Appl. No.:

12/303721
Inventors:

Leonard Guarente - Newton MA, US
Monty Krieger - Needham MA, US
Xiaoling Li - Chapel Hill NC, US
Assignee:

Massachusetts Institute of Technology - Cambridge MA
International Classification:

C12Q 1/68
C07K 14/435
G01N 33/68
C07J 9/00
C07C 59/00
C12N 15/00
G01N 33/559
US Classification:

435 6, 530350, 436 86, 552544, 562510, 435455, 204464
Abstract:

A cholesterol-regulating complex of SIRT1 and LXR and methods of use are disclosed. SIRT1 forms a complex with LXR bound to an LXR element. Methods of forming the complex, identifying an agent that modulates formation of the complex, increasing the ratio of cholesterol bound to high density lipoprotein (HDL) to total cholesterol in the plasma of a mammal, promoting ABCA1-mediated cholesterol efflux from a mammalian cell, treating a subject deemed to have a level of SIRT1 activity that is below normal, assessing whether a candidate substance modulates an LXR-dependent process, and assessing whether a candidate substance modulates an SIRT1-dependent effect of an LXR are disclosed.