Xiaoling Li

US Patent:

20080132444, Jun 5, 2008

Filed:

Sep 29, 2005

Appl. No.:

11/663608

Inventors:

Xiaoling Li - Danville CA, US
Bhaskara Jasti - Stockton CA, US
Ravichandran Mahalingam - Stockton CA, US

International Classification:

A61K 47/30
A61K 38/02
A61K 47/36
A61K 47/44
A61P 27/00
A61K 47/38
A61K 38/13

US Classification:

514 11, 5147723, 514 2, 514781, 514780, 514777, 514779

Abstract:

This invention is directed to novel ocular agent delivery systems and, in particular, emulsions and molecular dispersions in the form of a gel comprising a hydrophobic ocular agent.

US Patent:

20100216700, Aug 26, 2010

Filed:

Feb 22, 2010

Appl. No.:

12/710358

Inventors:

XIAOLING LI - Danville CA, US
Bhaskara Jasti - Stockton CA, US
Ravichandran Mahalingam - Stockton CA, US

International Classification:

A61K 38/13
A61K 38/16
A61P 27/02

US Classification:

514 11, 514 12

Abstract:

This invention is directed to treatments of ocular disorders using emulsions and molecular dispersions in the form of a gel comprising a hydrophobic ocular agent.

US Patent:

20100240029, Sep 23, 2010

Filed:

Jun 6, 2007

Appl. No.:

12/303721

Inventors:

Leonard Guarente - Newton MA, US
Monty Krieger - Needham MA, US
Xiaoling Li - Chapel Hill NC, US

Assignee:

Massachusetts Institute of Technology - Cambridge MA

International Classification:

C12Q 1/68
C07K 14/435
G01N 33/68
C07J 9/00
C07C 59/00
C12N 15/00
G01N 33/559

US Classification:

435 6, 530350, 436 86, 552544, 562510, 435455, 204464

Abstract:

A cholesterol-regulating complex of SIRT1 and LXR and methods of use are disclosed. SIRT1 forms a complex with LXR bound to an LXR element. Methods of forming the complex, identifying an agent that modulates formation of the complex, increasing the ratio of cholesterol bound to high density lipoprotein (HDL) to total cholesterol in the plasma of a mammal, promoting ABCA1-mediated cholesterol efflux from a mammalian cell, treating a subject deemed to have a level of SIRT1 activity that is below normal, assessing whether a candidate substance modulates an LXR-dependent process, and assessing whether a candidate substance modulates an SIRT1-dependent effect of an LXR are disclosed.