Xiaoling Lauling Li

US Patent:

20100240029, Sep 23, 2010

Filed:

Jun 6, 2007

Appl. No.:

12/303721

Inventors:

Leonard Guarente - Newton MA, US
Monty Krieger - Needham MA, US
Xiaoling Li - Chapel Hill NC, US

Assignee:

Massachusetts Institute of Technology - Cambridge MA

International Classification:

C12Q 1/68
C07K 14/435
G01N 33/68
C07J 9/00
C07C 59/00
C12N 15/00
G01N 33/559

US Classification:

435 6, 530350, 436 86, 552544, 562510, 435455, 204464

Abstract:

A cholesterol-regulating complex of SIRT1 and LXR and methods of use are disclosed. SIRT1 forms a complex with LXR bound to an LXR element. Methods of forming the complex, identifying an agent that modulates formation of the complex, increasing the ratio of cholesterol bound to high density lipoprotein (HDL) to total cholesterol in the plasma of a mammal, promoting ABCA1-mediated cholesterol efflux from a mammalian cell, treating a subject deemed to have a level of SIRT1 activity that is below normal, assessing whether a candidate substance modulates an LXR-dependent process, and assessing whether a candidate substance modulates an SIRT1-dependent effect of an LXR are disclosed.

US Patent:

20180112936, Apr 26, 2018

Filed:

Oct 21, 2016

Appl. No.:

15/331046

Inventors:

- BADEN, CH
PHILIP FREDERICK GILSTON - BURLINGTON CT, US
XIAOLING LI - SIMSBURY CT, US

Assignee:

GENERAL ELECTRIC TECHNOLOGY GMBH - BADEN

International Classification:

F28F 13/18
B23P 15/26
B21D 53/06
F28F 1/10

Abstract:

A method of manufacturing a tube is provided. The method includes: selecting a core pipe having a thickness that is initially less than a desired thickness of the tube; and building-up an outer layer over an exterior surface of the core pipe via additive manufacturing so as to increase the thickness of the core pipe such that the thickness of the core pipe is equal to the desired thickness of the tube.