Xiaoling L Li

US Patent:

20220339857, Oct 27, 2022

Filed:

May 24, 2022

Appl. No.:

17/752729

Inventors:

- Nanjing, CN
Xiaoling LI - Dublin CA, US
Feihuang DENG - Nanjing, CN
Haohui LU - Nanjing, CN
Haili LIU - Nanjing, CN
Juan YAO - Nanjing, CN
Xiaofei WANG - Nanjing, CN
Wei WU - Nanjing, CN

International Classification:

B29C 64/106
B29C 64/329
B29C 64/232
B29C 64/245
B29C 64/209
B29C 64/393
B29C 64/336

Abstract:

A 3D printing device (), comprising a melt extrusion module (), a printing module (), and a platform module (). The melt extrusion module () comprises a processing chamber () consisting of a feed inlet () and a discharge outlet (), as well as an extrusion means () and a heating means () disposed at the processing chamber; the melt extrusion module () is configured to receive an initial material from the feed inlet () of the processing chamber (), and heat and extrude the initial material to convert the initial material into a molten body, which is extruded out of the discharge outlet () of the processing chamber (). The printing module () is communicated with the discharge outlet () of the processing chamber () and is provided with a nozzle (); the printing module () is configured to receive the molten body extruded from the discharge outlet () of the processing chamber () and guide the molten body to be extruded out of the nozzle (). The platform module () is configured to receive the molten body extruded from the nozzle ().

US Patent:

20220212404, Jul 7, 2022

Filed:

Feb 3, 2022

Appl. No.:

17/592441

Inventors:

- Nanjing, CN
Feihuang DENG - Nanjing, CN
Wei WU - Nanjing, CN
Renjie LI - Nanjing, CN
Senping CHENG - Nanjing, CN
Xiaoling LI - Dublin CA, US

International Classification:

B29C 64/209
B33Y 10/00
B33Y 30/00
B33Y 80/00
B29C 64/245
B33Y 70/10
A61K 9/20

Abstract:

The present disclosure relates generally to manufacturing pharmaceutical products using additive manufacturing technology. An exemplary printing system comprises: a material supply module for receiving a set of printing materials; a flow distribution module comprising a flow distribution plate, wherein the material supply module is configured to transport a single flow corresponding to the set of printing materials to the flow distribution plate; wherein the flow distribution plate comprises a plurality of channels for dividing the single flow into a plurality of flows; a plurality of nozzles, wherein the plurality of nozzles comprises a plurality of needle-valve mechanisms; one or more controllers for controlling the plurality of needle-valve mechanisms to dispense the plurality of flows based on a plurality of nozzle-specific parameters; and a printing platform configured to receive the dispensed plurality of flows, wherein the printing platform is configured to move to form a batch of the pharmaceutical product.

US Patent:

20220212408, Jul 7, 2022

Filed:

Feb 3, 2022

Appl. No.:

17/592443

Inventors:

- Nanjing, CN
Feihuang DENG - Nanjing, CN
Wei WU - Nanjing, CN
Renjie LI - Nanjing, CN
Senping CHENG - Nanjing, CN
Xiaoling LI - Dublin CA, US

International Classification:

B29C 64/321
B33Y 10/00
B33Y 30/00
B33Y 40/00
B29C 64/209
B29C 64/118

Abstract:

The present disclosure relates generally to manufacturing pharmaceutical products using additive manufacturing technology. An exemplary printing system comprises: a material supply module for receiving a set of printing materials; a flow distribution module comprising a flow distribution plate, wherein the material supply module is configured to transport a single flow corresponding to the set of printing materials to the flow distribution plate; wherein the flow distribution plate comprises a plurality of channels for dividing the single flow into a plurality of flows; a plurality of nozzles, wherein the plurality of nozzles comprises a plurality of needle-valve mechanisms; one or more controllers for controlling the plurality of needle-valve mechanisms to dispense the plurality of flows based on a plurality of nozzle-specific parameters; and a printing platform configured to receive the dispensed plurality of flows, wherein the printing platform is configured to move to form a batch of the pharmaceutical product.

US Patent:

20230070928, Mar 9, 2023

Filed:

Feb 9, 2021

Appl. No.:

17/795466

Inventors:

- Nanjing, CN
Renjie LI - Nanjing, CN
Zhengping JIANG - Nanjing, CN
Feihuang DENG - Nanjing, CN
Haili LIU - Nanjing, CN
Senping CHENG - Nanjing, CN
Xiaoling LI - Dublin CA, US

International Classification:

B65B 35/18
B33Y 40/00
B33Y 80/00
B33Y 50/00
B29C 64/379
B29C 64/386
B29C 64/245
B65B 57/02
B65B 41/02
B65B 11/00
B65C 1/02
B65B 65/00
A61J 3/06

Abstract:

A high throughput, efficient, and simplified unloading and packaging systems and methods for large-scale production of pharmaceutical units () using additive manufacturing. The systems and methods may unload, inspect, package, and trace pharmaceutical units, produced by an additive manufacturing system (), that are not damaged or deformed. The unloading and packaging system can include one or more unloading and packaging devices (). The unloading and packaging device can include a modular configuration having modules. Individual modules to be arranged in any relative order, at any location, and with any number in the unloading and packaging device. The flexibility of the modular configuration allows one or more modules to be removed or added at any given time due to, e.g., expansion, downsizing, module repair, module upgrades, etc. High throughput can be achieved by operating unloading and packaging devices independently.

US Patent:

20230048362, Feb 16, 2023

Filed:

Aug 23, 2022

Appl. No.:

17/894101

Inventors:

- Nanjing, CN
Feihuang DENG - Nanjing, CN
Wei WU - Nanjing, CN
Renjie LI - Nanjing, CN
Senping CHENG - Nanjing, CN
Xiaoling LI - Dublin CA, US

Assignee:

Triastek, Inc. - Nanjing JS

International Classification:

B29C 64/321
B33Y 10/00
B33Y 30/00
B29C 64/209
B29C 64/118
B33Y 40/00

Abstract:

The present disclosure relates generally to manufacturing pharmaceutical products using additive manufacturing technology. An exemplary printing system comprises: a material supply module for receiving a set of printing materials; a flow distribution module comprising a flow distribution plate, wherein the material supply module is configured to transport a single flow corresponding to the set of printing materials to the flow distribution plate; wherein the flow distribution plate comprises a plurality of channels for dividing the single flow into a plurality of flows; a plurality of nozzles, wherein the plurality of nozzles comprises a plurality of needle-valve mechanisms; one or more controllers for controlling the plurality of needle-valve mechanisms to dispense the plurality of flows based on a plurality of nozzle-specific parameters; and a printing platform configured to receive the dispensed plurality of flows, wherein the printing platform is configured to move to form a batch of the pharmaceutical product.

US Patent:

20210154910, May 27, 2021

Filed:

May 11, 2018

Appl. No.:

16/614301

Inventors:

- Nanjing, CN
Xiaoling LI - Dublin CA, US
Feihuang DENG - Nanjing, CN
Haohui LU - Nanjing, CN
Haili LIU - Nanjing, CN
Juan YAO - Nanjing, CN
Xiaofei WANG - Nanjing, CN
Wei WU - Nanjing, CN

International Classification:

B29C 64/106
B29C 64/245
B29C 64/329
B29C 64/393
B29C 64/336
B29C 64/209
B29C 64/232

Abstract:

A 3D printing device (), comprising a melt extrusion module (), a printing module (), and a platform module (). The melt extrusion module () comprises a processing chamber () consisting of a feed inlet () and a discharge outlet (), as well as an extrusion means () and a heating means () disposed at the processing chamber; the melt extrusion module () is configured to receive an initial material from the feed inlet () of the processing chamber (), and heat and extrude the initial material to convert the initial material into a molten body, which is extruded out of the discharge outlet () of the processing chamber (). The printing module () is communicated with the discharge outlet () of the processing chamber () and is provided with a nozzle (); the printing module () is configured to receive the molten body extruded from the discharge outlet () of the processing chamber () and guide the molten body to be extruded out of the nozzle (). The platform module () is configured to receive the molten body extruded from the nozzle ().

US Patent:

20210128479, May 6, 2021

Filed:

Jan 25, 2018

Appl. No.:

16/481036

Inventors:

- Nanjing, CN
Xiaoling LI - Dublin CA, US
Feihuang DENG - Nanjing, CN
Juan YAO - Nanjing, CN

International Classification:

A61K 9/20
A61K 9/48
A61K 9/28
A61K 45/06

Abstract:

A dosage form of controlled release at specific gastrointestinal sites is provided. The dosage form includes a shell defining a first and a second compartment, a first active pharmaceutical ingredient (API) loaded in the first compartment, and a second API loaded in the second compartment, wherein the first API and the second API can be the same or different. The shell includes a first material soluble in a first gastrointestinal site and a second material soluble in a second gastrointestinal site.

US Patent:

20210078244, Mar 18, 2021

Filed:

Dec 25, 2018

Appl. No.:

16/960866

Inventors:

- Nanjing, CN
Xiaoling LI - Dublin CA, US
Senping CHENG - Nanjing, CN

International Classification:

B29C 64/118
A61K 9/00
B33Y 10/00
B33Y 50/02
B29C 64/393
A61K 9/20
A61K 9/48
A61J 3/00
A61J 3/07

Abstract:

In some aspects, the present disclosure provides dosage forms, such as oral drug dosage forms, configured to provide a desired release profile, the dosage forms comprising a multi-layered structure comprising a plurality of layers of a first erodible material admixed with a compound (e. g., a drug) or a reagent, wherein the first erodible material is embedded in a second material not admixed with the compound (e. g., the drug) or the reagent. In other aspects, the present disclosure provides methods of designing, such as obtaining a thickness and/or surface area of a layer comprising an erodible material admixed with a compound (e. g., a drug) or areagent, and/or amount of the compound (e. g., the drug) or the reagent admixed in the erodible material, and methods of making, such as three-dimensional printing, dosage forms configured to provide desired release profiles.