Xiaoying Ying Zhang

US Patent:

20040086566, May 6, 2004

Filed:

Nov 4, 2002

Appl. No.:

10/287410

Inventors:

Xiaoying Zhang - Morris Plains NJ, US

Assignee:

ALPHARMA, INC. - Fort Lee NJ

International Classification:

A61K009/24
A61K009/14

US Classification:

424/484000, 424/471000

Abstract:

In a preferred embodiment of the invention, a solid dosage form is provided comprising a matrix, wherein the matrix comprises (a) a pharmaceutically effective amount of metformin or a pharmaceutically acceptable salt thereof and (b) a waxy matrix material. The invention also provides a method of making a solid dosage form, the method comprising: (a) hot melting a waxy material to form a melt, (b) granulating metformin or a pharmaceutically acceptable salt thereof with the melt to form a granulate; (c) milling the granulate; and (d) compressing granulate to form a matrix.