Xin Lin

US Patent:

6645728, Nov 11, 2003

Filed:

Jun 1, 2001

Appl. No.:

09/871889

Inventors:

Warner C. Greene - Hillsborough CA
Xin Lin - San Francisco CA
Romas Gelezuinas - San Francisco CA

Assignee:

The Regents of the University of California - Oakland CA

International Classification:

G01N 33567

US Classification:

435 721, 435 71, 4241851, 530350, 530324

Abstract:

The present invention provides the molecular basis for cytokine induction of NF- B-dependent immune and inflammatory responses, emphasizing a role for both NIK-NIK and NIK-IKK proteinâprotein interactions. A relatively small region of NIK selectively impairs the NIK-IKK interaction. The present invention provides a novel and highly specific method for modulating NF- B-dependent immune, inflammatory, and anti-apoptotic responses, based on interruption of the critical proteinâprotein interaction of NIK and IKK. The present invention provides methods for inhibiting NF- B-dependent gene expression, using mutant NIK proteins. One embodiment of the present invention provides kinase-deficient NIK mutant proteins that inhibit activation of IKK. Another embodiment of the invention provides N-terminus NIK mutant proteins that bind IKK, thus inhibiting NIK/IKK interaction.

US Patent:

62655388, Jul 24, 2001

Filed:

Feb 25, 1999

Appl. No.:

9/257703

Inventors:

Warner C. Greene - Hillsborough CA
Xin Lin - San Francisco CA
Romas Gelezuinas - San Francisco CA

Assignee:

The Regents of the University of California - Oakland CA

International Classification:

A61K 3800
C07K 1600
C07K 1700
C07K 500
C07K 700

US Classification:

530324

Abstract:

The present invention provides the molecular basis for cytokine induction of NF-. kappa. B-dependent immune and inflammatory responses, emphasizing a role for both NIK-NIK and NIK-IKK protein-protein interactions. A relatively small region of NIK selectively impairs the NIK-IKK interaction. The present invention provides a highly specific method for modulating NF-. kappa. B-dependent immune, inflammatory, and anti-apoptotic responses, based on interruption of the critical protein-protein interaction of NIK and IKK. The present invention provides methods for inhibiting NF-. kappa. B-dependent gene expression, using mutant NIK proteins. One embodiment of the present invention provides kinase-deficient NIK mutant proteins that inhibit activation of IKK. Another embodiment of the invention provides N-terminus NIK mutant proteins that bind IKK, thus inhibiting NIK/IKK interaction.

US Patent:

20220372141, Nov 24, 2022

Filed:

May 24, 2022

Appl. No.:

17/752631

Inventors:

- South San Francisco CA, US
Xin Xin LIN - South San Francisco CA, US
Jeffrey GORRELL - South San Francisco CA, US
Timothy TULLY - South San Francisco CA, US
Matthew HUTCHINSON - South San Francisco CA, US
Charity Tucker BECHTEL - South San Francisco CA, US

Assignee:

Genentech, Inc. - South San Francisco CA

International Classification:

C07K 16/28
C07K 1/113
A61K 47/65
A61K 47/68
A61K 38/07

Abstract:

The invention provides improved methods of conjugating an agent to a thiol moiety in a protein that contains at least one disulfide bond and at least one trisulfide bond. Exemplary embodiments include the production of antibody drug conjugates substantially free of impurities created in the presence of reactive sulfide moieties in the production processes.

US Patent:

20230081342, Mar 16, 2023

Filed:

Jul 7, 2022

Appl. No.:

17/859835

Inventors:

- Cupertino CA, US
Aida R Colon-Berrios - Cupertino CA, US
Fan Gui - Sunnyvale CA, US
Levent Erdal Aygun - Cupertino CA, US
Mohammad Reza Esmaeili Rad - San Jose CA, US
Ran Tu - San Jose CA, US
Xin Lin - Santa Clara CA, US
Yun Wang - Cupertino CA, US

International Classification:

G09G 3/3233
H01L 27/32

Abstract:

A display may include an array of pixels. Each pixel in the array may include a drive transistor, emission transistors, a data loading transistor, a gate voltage setting transistor, an initialization transistor, an anode reset transistor, a storage capacitor, and an optional current boosting capacitor coupled in series with an isolation transistor. A data refresh may include a initialization phase, a threshold voltage sampling phase, and a data programming phase. The threshold voltage sampling phase can be substantially longer than the data programming phase to decrease a current sampling level during the threshold voltage sampling phase, which helps reduce the display luminance sensitivity to temperature variations. During a data refresh, the isolation transistor can be turned on to provide current boosting. During emission periods, the isolation transistor is turned off to prevent cathode noise from potentially coupling through to one or more direct-current voltage nodes in the pixel.

US Patent:

20200388215, Dec 10, 2020

Filed:

May 7, 2020

Appl. No.:

16/869329

Inventors:

- Cupertino CA, US
Junhua Tan - Saratoga CA, US
Wei H. Yao - Palo Alto CA, US
Shihchang Chang - Cupertino CA, US
Derek K. Shaeffer - Redwood City CA, US
Chaohao Wang - Sunnyvale CA, US
Hyunwoo Nho - Palo Alto CA, US
Yun Wang - Cupertino CA, US
Baris Cagdaser - Sunnyvale CA, US
Majid Gharghi - San Carlos CA, US
Yongjun Li - Fremont CA, US
Aida Raquel Colon-Berrios - Cupertino CA, US
Mohammad Reza Esmaeili Rad - San Jose CA, US
Hyunsoo Kim - Mountain View CA, US
Alex H. Pai - Milpitas CA, US
Hsin-Ying Chiu - San Jose CA, US
Jiun-Jye Chang - Cupertino CA, US
Xin Lin - Cupertino CA, US

International Classification:

G09G 3/3233
G09G 3/36
G09G 3/3291

Abstract:

An electronic device includes an electronic display having an active area comprising a pixel. The electronic device also includes processing circuitry configured to receive image data and predict a change in threshold voltage associated with a transistor of the pixel based at least in part on the image data. Furthermore, the processing circuitry is configured to adjust the image data to generate adjusted image data based at least in part on the predicted change in threshold voltage.

US Patent:

20170209593, Jul 27, 2017

Filed:

Jan 24, 2017

Appl. No.:

15/414330

Inventors:

- South San Francisco CA, US
Xin Xin LIN - South San Francisco CA, US
Jeffrey GORRELL - South San Francisco CA, US
Timothy TULLY - South San Francisco CA, US
Matthew HUTCHINSON - South San Francisco CA, US
Charity Tucker BECHTEL - South San Francisco CA, US

International Classification:

A61K 47/48
C07K 16/28
A61K 38/07
C07K 19/00

Abstract:

The invention provides improved methods of conjugating an agent to a thiol moiety in a protein that contains at least one disulfide bond and at least one trisulfide bond. Exemplary embodiments include the production of antibody drug conjugates substantially free of impurities created in the presence of reactive sulfide moieties in the production processes.