Guang-Zhong Wu - Somerville NJ Xing Chen - Plainsboro NJ Doris P. Schumacher - Bedminster NJ Martin Steinman - Livingston NJ
Assignee:
Schering Corporation - Kenilworth NJ
International Classification:
C07D20508
US Classification:
540200
Abstract:
The invention relates to a process for producing a compound of the formula ##STR1## wherein R. sub. 1, R. sub. 2 and R. sub. 3 are as defined in the specification, which comprises the steps of: (a) reacting a lactone with an imine to obtain a chiral diol of the formula IV; (b) oxidizing the diol to obtain an aldehyde of formula V; (c) condensing the aldehyde with an enolether followed by dehydration to obtain a compound of formula VI; (d) hydrogenating the compound of formula VI to obtain a ketone of formula VII; and (e) chirally catalytically reducing the ketone, wherein steps (b)-(d) are shown in the following reaction scheme: ##STR2##.
3-Hydroxy .Gamma.-Lactone Based Enantionselective Synthesis Of Azetidinones
Guang-Zhong Wu - Somerville NJ Xing Chen - Plainsboro NJ Doris P. Schumacher - Bedminster NJ Martin Steinman - Livingston NJ
Assignee:
Schering Corporation - Kenilworth NJ
International Classification:
C07D20504
US Classification:
540200
Abstract:
The invention relates to a process for producing the compound of the formula ##STR1## which comprises reacting lactone of formula II ##STR2## with an imine of formula III': ##STR3## and converting the resulting chiral diol of formula VI: ##STR4## through several steps to obtain a compound of formula I'.