Xing X Cheng

US Patent:

7572904, Aug 11, 2009

Filed:

Mar 26, 2004

Appl. No.:

10/811508

Inventors:

Xing Cheng - Sunnyvale CA, US
Hyun Jung Park - Sunnyvale CA, US
Hong Jin - Cupertino CA, US

Assignee:

MedImmune, LLC - Gaithersburg MD

International Classification:

C07H 21/00
A61K 39/155

US Classification:

536 2372, 4242111

Abstract:

The complete polynucleotide sequence of the human respiratory syncytial virus subgroup B strain 9320 genome is provided. Proteins encoded by this polynucleotide sequence are also provided. Isolated or recombinant RSV (e. g. , attenuated recombinant RSV), nucleic acids, and polypeptides, e. g. , comprising mutations in the attachment protein G, are also provided, as are immunogenic compositions comprising such isolated or recombinant RSV, nucleic acids, and polypeptides. Related methods are also described.

US Patent:

8163530, Apr 24, 2012

Filed:

Jul 23, 2009

Appl. No.:

12/508075

Inventors:

Xing Cheng - Sunnyvale CA, US
Hyun Jung Park - Sunnyvale CA, US
Hong Jin - Cupertino CA, US

Assignee:

MedImmune, LLC - Gaithersburg MD

International Classification:

C12N 7/00
C12N 7/01
C12N 7/04
A61K 39/155

US Classification:

4352351, 435236, 4242111, 536 2372

Abstract:

The complete polynucleotide sequence of the human respiratory syncytial virus subgroup B strain 9320 genome is provided. Proteins encoded by this polynucleotide sequence are also provided. Isolated or recombinant RSV (e. g. , attenuated recombinant RSV), nucleic acids, and polypeptides, e. g. , comprising mutations in the attachment protein G, are also provided, as are immunogenic compositions comprising such isolated or recombinant RSV, nucleic acids, and polypeptides. Related methods are also described.

US Patent:

8613935, Dec 24, 2013

Filed:

Feb 3, 2010

Appl. No.:

12/699108

Inventors:

Hong Jin - Cupertino CA, US
Xing Cheng - Sunnyvale CA, US
Kanta Subbarao - Washington DC, US

Assignee:

Medimmune, LLC - Gaithersburg MD

International Classification:

A61K 39/145
A61P 31/16
C12N 7/01
C12N 7/02

US Classification:

4242061, 4242091, 4241861, 4352351, 435239

Abstract:

Polypeptides, polynucleotides, reassortant viruses, immunogenic compositions and vaccines comprising influenza hemagglutinin and neuraminidase variants and method using thereof are provided.

US Patent:

20050176130, Aug 11, 2005

Filed:

Sep 26, 2003

Appl. No.:

10/672302

Inventors:

Hong Jin - Cupertino CA, US
Bin Lu - Los Altos CA, US
Xing Cheng - Sunnyvale CA, US
Helen Zhou - Palo Alto CA, US

Assignee:

MedImmune Vaccines, Inc. - Mountain View CA

International Classification:

C12N007/01

US Classification:

435235100

Abstract:

The present invention provides recombinant respiratory syncytial viruses that have an attenuated phenotype and that comprise one or more mutations in the viral P, M2-1 and/or M2-2 proteins, as well as live attenuated vaccines comprising such viruses and nucleic acids encoding such viruses. Recombinant RSV P, M2-1 and M2-2 proteins are described. Methods of producing attenuated recombinant RSV, and methods of quantitating neutralizing antibodies that utilize recombinant viruses of family Paramyxoviridae, are also provided.

US Patent:

20120263744, Oct 18, 2012

Filed:

Apr 17, 2012

Appl. No.:

13/449087

Inventors:

Xing Cheng - Sunnyvale CA, US
Hyun Jung Park - Sunnyvale CA, US
Hong Jin - Cupertino CA, US

Assignee:

MedImmune, LLC - Gaithersburg MD

International Classification:

A61K 39/155
A61P 31/14

US Classification:

4241861, 4242111

Abstract:

The complete polynucleotide sequence of the human respiratory syncytial virus subgroup B strain 9320 genome is provided. Proteins encoded by this polynucleotide sequence are also provided. Isolated or recombinant RSV (e.g., attenuated recombinant RSV), nucleic acids, and polypeptides, e.g., comprising mutations in the attachment protein G, are also provided, as are immunogenic compositions comprising such isolated or recombinant RSV, nucleic acids, and polypeptides. Related methods are also described.

US Patent:

20140079726, Mar 20, 2014

Filed:

Nov 21, 2013

Appl. No.:

14/086902

Inventors:

Xing CHENG - Sunnyvale CA, US
Kanta SUBBARAO - Washington DC, US

Assignee:

MEDIMMUNE, LLC - Gaithersburg MD

International Classification:

A61K 39/145

US Classification:

4241861, 4352351, 435239

Abstract:

Polypeptides, polynucleotides, reassortant viruses, immunogenic compositions and vaccines comprising influenza hemagglutinin and neuraminidase variants and method using thereof are provided.