Xing Li

US Patent:

20050191687, Sep 1, 2005

Filed:

Feb 26, 2005

Appl. No.:

11/067237

Inventors:

Tianxin Wang - Columbia MD, US
Xing Li - Vienna VA, US

International Classification:

C12Q001/68
C07H021/04
C12M001/34

US Classification:

435006000, 536024300, 435287200

Abstract:

The methods and compositions provided herein are based on use of reporter system to detect multiple analyte in a sample. The reporter system can be a signal amplification system that includes a carrier, typically a particle containing an analyte binding moiety, and multiple copies of a signaling moiety. Different reporter system can bind with different analyte. Different reporter system or their signaling moiety can be distinguished and detected. In various embodiments, the signaling moiety is physically released from its carrier after the carrier has been bound to the analyte and distinguished and detected after the release.

US Patent:

20110097753, Apr 28, 2011

Filed:

Oct 15, 2008

Appl. No.:

12/287916

Inventors:

Tianxin Wang - Boyds MD, US
Xing Xiang Li - Vienna VA, US

International Classification:

C12Q 1/66
C07H 17/00
C07H 15/26

US Classification:

435 8, 536 181, 536 174

Abstract:

The present invention relates to chemiluminescent method and regent to detect analyte. One aspect of the current invention relates to using enzyme substrate that can be cleaved by target enzyme to release chemiluminescent compound giving light signal for the detection of varieties of target enzymes. Another aspect of the current invention relates to use chemiluminescent enzyme coupled with analyte binding molecules to detect specific analyte molecules in a homogenous phase.

US Patent:

20110189655, Aug 4, 2011

Filed:

Feb 2, 2011

Appl. No.:

13/019737

Inventors:

Xing Xiang Li - Vienna VA, US
Tianxin Wang - Boyds MD, US

International Classification:

C12Q 1/70
C07H 15/26
C12Q 1/66

US Classification:

435 5, 536 174, 435 18, 435 8

Abstract:

The present invention relates to reagents and methods for influenza virus detection. These reagents and methods disclosed in the present invention enable simple, rapid, specific and sensitive detection of influenza virus types A and B. These reagents are N-acetylneuraminic acid-firefly luciferin conjugates which can be cleaved by influenza virus neuraminidase.

US Patent:

20140249406, Sep 4, 2014

Filed:

Nov 5, 2013

Appl. No.:

14/072270

Inventors:

- Iowa City IA, US
Yusung Kim - Iowa City IA, US
Xing Li - Iowa City IA, US

Assignee:

UNIVERSITY OF IOWA RESEARCH FOUNDATION - Iowa City IA

International Classification:

A61N 5/10

US Classification:

600424, 600 8

Abstract:

Compensator-based brachytherapy (CBT) for treatment of cancerous tumors or other pathologic tissues. CBT permits, in one aspect, increased dosage conformity for non-radially symmetric tumors by utilizing a device that can shield radiation emanated from an electronic brachytherapy (BT) source or non-electronic BT source. The device can comprise, in one aspect, a radiation compensator having a treated surface that comprises a position-dependent thickness based at least on a radiation therapy plan specific to a patient and geometry of a patient region to be treated. In an additional or alternative aspect, the device can comprise a source of radiation movably inserted into an enclosure coupled to the radiation compensator. As part of CBT, in one implementation, the radiation source can reside at a plurality of locations within the radiator compensator during a respective plurality of dwell times based on the radiation therapy plan.