Xing N Li

US Patent:

20050191687, Sep 1, 2005

Filed:

Feb 26, 2005

Appl. No.:

11/067237

Inventors:

Tianxin Wang - Columbia MD, US
Xing Li - Vienna VA, US

International Classification:

C12Q001/68
C07H021/04
C12M001/34

US Classification:

435006000, 536024300, 435287200

Abstract:

The methods and compositions provided herein are based on use of reporter system to detect multiple analyte in a sample. The reporter system can be a signal amplification system that includes a carrier, typically a particle containing an analyte binding moiety, and multiple copies of a signaling moiety. Different reporter system can bind with different analyte. Different reporter system or their signaling moiety can be distinguished and detected. In various embodiments, the signaling moiety is physically released from its carrier after the carrier has been bound to the analyte and distinguished and detected after the release.

US Patent:

20110097753, Apr 28, 2011

Filed:

Oct 15, 2008

Appl. No.:

12/287916

Inventors:

Tianxin Wang - Boyds MD, US
Xing Xiang Li - Vienna VA, US

International Classification:

C12Q 1/66
C07H 17/00
C07H 15/26

US Classification:

435 8, 536 181, 536 174

Abstract:

The present invention relates to chemiluminescent method and regent to detect analyte. One aspect of the current invention relates to using enzyme substrate that can be cleaved by target enzyme to release chemiluminescent compound giving light signal for the detection of varieties of target enzymes. Another aspect of the current invention relates to use chemiluminescent enzyme coupled with analyte binding molecules to detect specific analyte molecules in a homogenous phase.

US Patent:

20110189655, Aug 4, 2011

Filed:

Feb 2, 2011

Appl. No.:

13/019737

Inventors:

Xing Xiang Li - Vienna VA, US
Tianxin Wang - Boyds MD, US

International Classification:

C12Q 1/70
C07H 15/26
C12Q 1/66

US Classification:

435 5, 536 174, 435 18, 435 8

Abstract:

The present invention relates to reagents and methods for influenza virus detection. These reagents and methods disclosed in the present invention enable simple, rapid, specific and sensitive detection of influenza virus types A and B. These reagents are N-acetylneuraminic acid-firefly luciferin conjugates which can be cleaved by influenza virus neuraminidase.

US Patent:

20230104751, Apr 6, 2023

Filed:

Oct 19, 2022

Appl. No.:

17/969314

Inventors:

- San Jose CA, US
Peter Nahas - Watertown MA, US
Xing Li - Burlington MA, US
Suji Suresh - Westford MA, US
Daniel R. Perkins - Boston MA, US
Peter Smith - Acton MA, US

International Classification:

H04L 45/02
H04L 9/40
H04L 47/70

Abstract:

Systems and methods include receiving network communication information about hosts in a network and applications executed on the hosts; automatically generating one or more microsegments in the network based on analysis of the obtained network communication information, wherein each microsegment of the one or more microsegments is a grouping of resources including the hosts and the applications executed on the hosts that have rules for network communication; and providing the one or more microsegments to one or more hosts of the hosts, for use by the one or more hosts to allow or block communications locally based on the one or more microsegments. Each of the one or more microsegments can be a grouping of workloads inside a data center.

US Patent:

20210332383, Oct 28, 2021

Filed:

Dec 9, 2020

Appl. No.:

17/116098

Inventors:

- Lexington MA, US
Xing Li - LEXINGTON MA, US

International Classification:

C12N 15/86
C12N 9/16
A61K 9/00

Abstract:

The present disclosure provides, among other things, a recombinant adeno-associated virus (rAAV) vector comprising an AAV8 or AAV9 capsid and a codon-optimized sequence encoding a human iduronate-2-sulfatase (I2S) enzyme. The disclosure also provides a method of treating a subject having Hunter syndrome (MPS II), comprising administering to the subject in need thereof a recombinant adeno-associated virus (rAAV) vector comprising an AAV8 or AAV9 capsid, and a promoter operably linked to a nucleic acid sequence that encodes iduronate-2-sulfatase (I2S), and wherein administering results in an increase in I2S enzymatic activity in the subject.

US Patent:

20210314250, Oct 7, 2021

Filed:

Jun 17, 2021

Appl. No.:

17/350180

Inventors:

- San Jose CA, US
Peter Nahas - Watertown MA, US
Xing Li - Burlington MA, US
Suji Suresh - Westford MA, US
Daniel R. Perkins - Boston MA, US
Peter Smith - Acton MA, US

International Classification:

H04L 12/751
H04L 12/911
H04L 29/06

Abstract:

Systems and methods include, subsequent to performing auto segmentation on a network that includes a set of policies of allowable and block communications, observing communication between a plurality of hosts on the network; determining unassigned communication paths based on the observing that are either blocked because of a lack of a policy of the set of policies or because there is no policy of the set of policies for coverage thereof; and assigning the unassigned communication paths to corresponding policies of the set of policies. The assigning can be based on heuristics. The assigning can be performed without reperforming auto segmentation.

US Patent:

20210275614, Sep 9, 2021

Filed:

Oct 24, 2019

Appl. No.:

17/288141

Inventors:

- Osaka, JP
Xing LI - Jamaica Plain MA, US

Assignee:

Takeda Pharmaceutical Company Limited - Osaka

International Classification:

A61K 35/761
A61K 38/17

Abstract:

A triple-plasmid system for producing recombinant adeno-associated viruses is disclosed.

US Patent:

20200396255, Dec 17, 2020

Filed:

Jun 11, 2020

Appl. No.:

16/898997

Inventors:

- San Jose CA, US
Aparna Ayikkara - Brookline NH, US
Omar Baba - Winchester MA, US
Daniel Einspanjer - Salem NH, US
Anthony Gelsomini - Westwood MA, US
Thomas C. Hickman - Hollis NH, US
Peter Kahn - Southborough MA, US
Andriy Kochura - North Andover MA, US
Nikitha Koppu - Shrewsbury MA, US
Scott Laplante - Bedford NH, US
Xing Li - Burlington MA, US
Raymond Brian Liu - Lexington MA, US
Sean Lutner - Norfolk MA, US
Michael J. Melson - Arlington MA, US
Peter Nahas - Watertown MA, US
John O'Neil - Watertown MA, US
Herman Parfenov - Andover MA, US
Joseph Riopel - Worcester MA, US
Suji Suresh - Westford MA, US
Harry Sverdlove - North Reading MA, US

International Classification:

H04L 29/06
H04W 12/08
H04L 29/08
H04L 12/24

Abstract:

A computer system automatically generates a proposal for performing microsegmentation on a network. The system provides output representing the proposed microsegmentation to a user. The user provides input either approving or disapproving of the proposed microsegmentation. If the user approves of the proposed microsegmentation, then the system implements the microsegmentation. Otherwise, the system does not implement the proposed microsegmentation. This process may be repeated for a plurality of proposed microsegmentations within the same network, and may be repeated over time to modify one or more existing microsegmentations. The system advantageously performs the vast majority of the work required to microsegment the network automatically, leaving only the task of review and approval to the user. This both saves a significant amount of time and increases the quality of the microsegmentation in comparison to microsegmentation solely performed manually by one or more humans.