Yakang L Lin

US Patent:

20120082628, Apr 5, 2012

Filed:

Sep 29, 2011

Appl. No.:

13/248308

Inventors:

John Christian Haught - West Chester OH, US
Christine Marie Cahen - Tervuren, BE
Wenzhu Zhao - Mason OH, US
Yakang Lin - Liberty Township OH, US
Cathy Renee Schinaman - West Harrison IN, US

International Classification:

A61K 8/58
A61Q 11/00
A61K 8/60
A61K 8/37
A61K 8/49

US Classification:

424 51, 424 49, 424 55, 424 52, 424 57

Abstract:

Oral care compositions having improved taste, said compositions comprising: a carrier material; from about 0.001 to about 10%, by weight of the composition, of an oral care component selected from metal salts, antimicrobial agents, bad breath reduction agents, bleaching agents, surfactants, or a combination thereof; and from about 0.0001 to about 1%, by weight of the composition, of a TRPA1 agonist selected from vanillin esters; benzoate esters; hydroxybenzoate derivatives; methoxy benzoate derivatives; hydroxybutanedioate derivatives; benzamidobenzoate derivatives; methylpropanoate derivatives; phenyl acetate derivatives; hex-3-enoate derivatives; 2-(furan-2-ylmethylsulfanyl)-3-methylpyrazine; phenylmethoxymethylbenzene; (2R)-2-azaniumyl-3-[(2R)-2-azaniumyl-3-oxido-3-oxopropyl]disulfanylpropanoate; (3E)-2-hydroxy-4,8-dimethylnona-3,7-dienal; (2R)-2-azaniumyl-3-[(2S)-2-azaniumyl-3-oxido-3-oxopropyl]disulfanylpropanoate; (3Z)-3-butylidene-2-benzofuran-1-one; 3-methyl-N-(3-methylbutyl)butan-1-imine; 2-(furan-2-ylmethyldisulfanylmethyl)furan; and combinations thereof. Uses thereof and methods of improving the taste of an oral care composition.

US Patent:

20100278991, Nov 4, 2010

Filed:

Apr 20, 2010

Appl. No.:

12/763933

Inventors:

John Christian Haught - West Chester OH, US
Koti Tatachar Sreekrishna - Mason OH, US
Yakang Lin - Liberty Twp OH, US
Lowell Alan Sanker - Mason OH, US

International Classification:

A23L 1/22

US Classification:

426532, 426538

Abstract:

Provided herein are compositions and methods relating to oral care compositions with improved taste. One such method includes providing an oral care composition comprising a metal salt, a peroxide, an antimicrobial agent, a bad breath reduction agent, a surfactant, or a combination thereof and adding to the oral care composition a TRPV1 activator and/or vanitrope.

US Patent:

20200405800, Dec 31, 2020

Filed:

Apr 20, 2018

Appl. No.:

15/958921

Inventors:

- McLean VA, US
Ping Hu - Mason OH, US
Yakang Lin - Liberty Township OH, US
Lori Ann Reinsalu - Cincinnati OH, US

Assignee:

Mars, Incorporated - McLean VA

International Classification:

A61K 36/9066
A61K 36/484
A61K 36/752
A61K 45/06
A61K 36/889
A61K 36/736
A61K 36/718
A61K 36/708
A61K 36/67
A61K 36/634
A61K 36/61
A61K 36/55
A61K 36/54
A61K 36/53
A61K 36/48
A61K 36/47
A61K 36/45
A61K 36/41
A61K 36/324
A61K 36/28
A61K 36/23
A61K 36/19
A61K 36/185
A61K 36/16
A61K 36/15
A61K 36/00
A61K 36/9068
A61K 36/88
A61K 36/87
A61K 36/835
A61K 36/82
A61K 36/81
A61K 36/77

Abstract:

The present invention relates to compositions containing plant materials or extracts with inhibitory effect on a 5-HTand/or NK-1 receptor for preventing or treating idiopathic vomiting.

US Patent:

20190276389, Sep 12, 2019

Filed:

Dec 14, 2016

Appl. No.:

15/378547

Inventors:

- Cincinnati OH, US
Kenneth Edward YELM - Hamilton OH, US
Gregory Mark BUNKE - Lawrenceburg IN, US
Heath Alan FREDERICK - Harrison OH, US
Michael REILLY - Lebanon OH, US
John Christian HAUGHT - West Chester OH, US
Koti Tatachar SREEKRISHNA - Mason OH, US
Yakang LIN - Liberty Township OH, US

International Classification:

C07C 237/22
C07C 231/16
C07B 51/00
C07C 231/12
C07C 231/02

Abstract:

Personal care compositions, such as oral care and skin care compositions containing a flavor/perfume system comprising one or more coolants. The pleasant cool sensation provided by a coolant is enhanced in terms of quicker onset, greater intensity, impact or longer duration, which improves appeal and acceptability of the compositions to consumers.

US Patent:

20180312463, Nov 1, 2018

Filed:

Jul 9, 2018

Appl. No.:

16/030382

Inventors:

- Cincinnati OH, US
John August WOS - Mason OH, US
Gregory Mark BUNKE - Lawrenceburg IN, US
Heath FREDERICK - Cincinnati OH, US
John Christian HAUGHT - West Chester OH, US
Steven Hamilton HOKE - West Chester OH, US
Koti Tatachar SREEKRISHNA - Cincinnati OH, US
Yakang LIN - Liberty Township OH, US

International Classification:

C07C 237/10
C07C 269/06
C07C 231/02
C07D 213/81
C07C 319/20
A61K 8/41
A61Q 11/00
C07C 233/62
C07C 271/20
C07C 271/22
C07C 237/22
C07C 233/78
C07C 321/14

Abstract:

Synthesis methods to produce a series of carboxamides built off of an (S)-2-amino acid backbone or an (R)-2-amino acid backbone, depending upon the desired diastereomer of the end product.

US Patent:

20180228746, Aug 16, 2018

Filed:

Apr 5, 2018

Appl. No.:

15/945906

Inventors:

- Cincinnati OH, US
Michael Reilly - Lebanon OH, US
Steven Hamilton Hoke - West Chester OH, US
Qingxin Lei - Liberty Township OH, US
Yakang Lin - Liberty Township OH, US
Koti Tatachar Sreekrishna - Mason OH, US
Ashraf Traboulsi - West Chester OH, US

International Classification:

A61K 31/165
A61K 9/28
A61K 31/09
A61K 9/06
A61K 9/00
A61Q 11/00
A61K 8/42
A61K 8/46
A61Q 5/02
A61Q 9/02
C07C 323/33
C07C 233/73
C07C 233/75
C07C 237/10
C07C 255/44
A23G 4/06
A61K 31/485
A61K 31/4402
A61K 31/192
A61K 31/167
A61K 31/137

Abstract:

Personal care compositions, such as oral medication compositions containing a flavor system comprising one or more coolants. The pleasant cool sensation provided by a coolant is enhanced in terms of quicker onset, greater intensity, impact or longer duration, which improves appeal and acceptability of the compositions to consumers.

US Patent:

20180049960, Feb 22, 2018

Filed:

Nov 3, 2017

Appl. No.:

15/803369

Inventors:

- Cincinnati OH, US
Yakang Lin - Liberty Township OH, US

International Classification:

A61K 8/35
A61Q 11/00
A61K 8/49
A61K 8/31
G01N 33/50
G01N 33/68
A61K 31/11
A61K 8/33

Abstract:

Compounds and methods for modifying sensory perception associated with transient sensory receptors TRPA1, TRPV1, and TRPA1V1. A method for screening compounds for modulation of TRPA1, TRPV1, and/or TRPA1V1. Compositions comprising TRPA1V1 agonists or antagonists, for modifying sensory perception of the compositions.

US Patent:

20170333325, Nov 23, 2017

Filed:

Aug 4, 2017

Appl. No.:

15/669576

Inventors:

- Cincinnati OH, US
Koti Tatachar SREEKRISHNA - Mason OH, US
Yakang LIN - Liberty Township OH, US
Carrita Anne HIGHTOWER - Morrow OH, US
Pierig Jean-Marie LEPONT - Wyoming OH, US

International Classification:

A61K 8/49
A61K 8/35
A61K 8/36
G01N 33/68
A61Q 11/00
A61K 33/30
A61K 31/4425
A61K 31/40
A61K 31/235
A61K 31/222
A61K 31/215
A61K 31/192
A61K 8/34
A61K 31/045
A61K 8/73
A61K 8/60
A61K 8/46
A61K 8/44
A61K 8/41
A61K 8/37
A61K 8/365
A61K 31/121

Abstract:

A method for screening compounds and compositions that reduce cetyl pyridinium chloride activation of TRPA1 receptor or TRPV1 receptor.