Yan Chen

US Patent:

7125663, Oct 24, 2006

Filed:

Jun 12, 2002

Appl. No.:

10/171311

Inventors:

Robert Schlegel - Auburndale MA, US
Yan Chen - Cambridge MA, US
Xumei Zhao - Burlington MA, US
John E. Monahan - Walpole MA, US
Shubhangi Kamatkar - Newton MA, US
Manjula Gannavarapu - Acton MA, US
Karen Glatt - Natick MA, US
Sebastian Hoersh - Arlington MA, US

Assignee:

Millenium Pharmaceuticals, Inc. - Cambridge MA

International Classification:

C12Q 1/68

US Classification:

435 6, 435 723, 530350, 5303877, 5303913, 536 235, 536 2431, 436 65

Abstract:

The invention relates to newly discovered nucleic acid molecules and proteins associated with cervical cancer including pre-malignant conditions such as dysplasia. Compositions, kits, and methods for detecting, characterizing, preventing, and treating human cervical cancers are provided.

US Patent:

7644271, Jan 5, 2010

Filed:

Nov 7, 2005

Appl. No.:

11/268232

Inventors:

Mikhail Cherepov - Lexington MA, US
Yan Chen - Boonton Township NJ, US

Assignee:

Cisco Technology, Inc. - San Jose CA

International Classification:

H04L 29/06
G06F 12/14
G06F 12/16

US Classification:

713164, 726 22, 726 23, 726 24

Abstract:

A method and computer program product for providing enforcement of security policies for kernel module loading is presented. File paths for shared library executable files opened by user processes are cached. When a request to load a kernel loadable module (KLM) is received, a previously cached file path for said KLM is retrieved, said file path mapping a location of an executable file from which said KLM was produced. A security policy is applied to said file path, wherein when said file path triggers a security policy rule then an action associated with a triggered rule is taken, and wherein when said file path does not trigger a security policy rule then said KLM request is allowed to proceed.

US Patent:

7793763, Sep 14, 2010

Filed:

May 8, 2006

Appl. No.:

11/429243

Inventors:

Weidong Zhu - Elridge MD, US
Yan Chen - Baltimore MD, US

Assignee:

University of Maryland, Baltimore County - Baltimore MD

International Classification:

B66B 7/06
B66B 5/00
B66D 1/00
B66C 13/06

US Classification:

187411, 187251, 187345, 187393, 187414, 254277, 212273

Abstract:

A vibration damped elevator system is provided that includes a damper or dampers attached to the elevator cable. The damping coefficients of the damper or dampers are chosen to provide optimum dissipation of the vibratory energy in the elevator cable. A method of determining the optimum placement of the damper or dampers and their respective damping coefficients is also provided.

US Patent:

7846737, Dec 7, 2010

Filed:

Aug 25, 2006

Appl. No.:

11/510530

Inventors:

Robert Schlegel - Auburndale MA, US
Yan Chen - Acton MA, US
Xumei Zhao - Wayland MA, US
John E. Monahan - Walpole MA, US
Shubhangi Kamatkar - Newton MA, US
Manjula Gannavarapu - Acton MA, US
Karen Glatt - Natick MA, US
Sebastian Hoersch - Arlington MA, US

Assignee:

Millennium Pharmaceuticals, Inc. - Cambridge MA

International Classification:

G01N 33/48
G01N 33/574

US Classification:

436 64, 435 6, 435 71, 435 723, 530350, 5303877, 536 235, 536 243

Abstract:

The invention relates to newly discovered nucleic acid molecules and proteins associated with cervical cancer including pre-malignant conditions such as dysplasia. Compositions, kits, and methods for detecting, characterizing, preventing, and treating human cervical cancers are provided.

US Patent:

7847062, Dec 7, 2010

Filed:

Jul 7, 2006

Appl. No.:

11/482641

Inventors:

Yan Chen - Lexington MA, US
Elena Getmanova - Lexington MA, US
Martin C. Wright - Boston MA, US
Alan S. Harris - Andover MA, US
Ai Ching Lim - Mercer Island WA, US
Jochem Gokemeijer - Boston MA, US
Lin Sun - West Roxbury MA, US
Michael Wittekind - Bainbridge Island WA, US

Assignee:

Bristol-Myers Squibb Company - Princeton NJ

International Classification:

C07K 14/78
A61K 38/39

US Classification:

530320, 530345, 530350, 530402, 514 12

Abstract:

The present disclosure relates to novel vascular endothelial growth factor receptor (VEGFR)-binding polypeptides and methods for using these polypeptides to inhibit biological activities mediated by vascular endothelial growth factors (VEGFs). The present disclosure also provides various improvements relating to single domain binding polypeptides.

US Patent:

7858739, Dec 28, 2010

Filed:

Jun 5, 2006

Appl. No.:

11/448171

Inventors:

Yan Chen - Lexington MA, US
Elena Getmanova - Lexington MA, US
Martin C. Wright - Boston MA, US
Alan S. Harris - Andover MA, US
Ai Ching Lim - Newton MA, US
Jochem Gokemeijer - Arlington MA, US
Lin Sun - West Roxbury MA, US
Michael Wittekind - Bainbridge Island WA, US

Assignee:

Bristol-Myers Squibb Company - Princeton NJ

International Classification:

C07K 14/78
A61K 38/39

US Classification:

530324, 530345, 530350, 530402, 514 12

Abstract:

The present disclosure relates to novel vascular endothelial growth factor receptor (VEGFR)-binding polypeptides and methods for using these polypeptides to inhibit biological activities mediated by vascular endothelial growth factors (VEGFs). The present disclosure also provides various improvements relating to single domain binding polypeptides.

US Patent:

7915388, Mar 29, 2011

Filed:

Sep 7, 2007

Appl. No.:

11/899819

Inventors:

Chengbin Wu - Shrewsbury MA, US
Richard W. Dixon - Jefferson MA, US
Jonathan P. Belk - Sterling MA, US
Maria A. Argiriadi - Wayland MA, US
Hua Ying - Holden MA, US
Carolyn A. Cuff - Grafton MA, US
Terry L. Melim - Derry NH, US
Shankar Kumar - Pleasanton CA, US
Paul R. Hinton - Sunnyvale CA, US
Yan Chen - Fremont CA, US

Assignee:

Abbott Laboratories - Abbott Park IL

International Classification:

C12P 21/08

US Classification:

5303879, 4241331

Abstract:

The present invention encompasses IL-13 binding proteins. Specifically, the invention relates to antibodies that are chimeric, CDR grafted and humanized antibodies. Preferred antibodies have high affinity for hIL-13 and neutralize hIL-13 activity in vitro and in vivo. An antibody of the invention can be a full-length antibody or an antigen-binding portion thereof. Method of making and method of using the antibodies of the invention are also provided. The antibodies, or antibody portions, of the invention are useful for detecting hIL-13 and for inhibiting hIL-13 activity, e. g. , in a human subject suffering from a disorder in which hIL-13 activity is detrimental.

US Patent:

8062892, Nov 22, 2011

Filed:

Jun 14, 2010

Appl. No.:

12/814849

Inventors:

Robert Schlegel - Auburndale MA, US
Yan Chen - Acton MA, US
Xumei Zhao - Wayland MA, US
John E. Monahan - Walpole MA, US
Shubhangi Kamatkar - Newton MA, US
Manjula Gannavarapu - Acton MA, US
Karen Glatt - Natick MA, US
Sebastian Hoersch - Arlington MA, US

Assignee:

Millennium Pharmaceuticals, Inc. - Cambridge MA

International Classification:

G01N 33/48
G01N 33/574

US Classification:

436 64, 435 6, 435 71, 435 723, 530350, 5303877, 536 235, 536 243

Abstract:

The invention relates to newly discovered nucleic acid molecules and proteins associated with cervical cancer including pre-malignant conditions such as dysplasia. Compositions, kits, and methods for detecting, characterizing, preventing, and treating human cervical cancers are provided.