Yan Chen

US Patent:

7365154, Apr 29, 2008

Filed:

Jun 22, 2004

Appl. No.:

10/873848

Inventors:

David Shealy - Downingtown PA, US
Sam Wu - Broomall PA, US
Yan Chen - Wayne PA, US
Audrey Baker - Philadelphia PA, US

Assignee:

Centocor, Inc. - Malvern PA

International Classification:

A61K 38/04

US Classification:

530327

Abstract:

The invention concerns antagonists of alphav-containing integrins which have therapeutic activity in oncology applications and methods for selecting such antagonists using a peptide which competes for alphaV-integrin binding with a known monoclonal antibody having demonstrated anti-tumor activity. The claimed peptide represents a conformational epitope or mimotope present on the ligand to which the therapeutic antibodies selectively bind.

US Patent:

7361511, Apr 22, 2008

Filed:

Aug 20, 2003

Appl. No.:

10/645756

Inventors:

John E. Monahan - Walpole MA, US
Xumei Zhao - Wayland MA, US
Yan Chen - Cambridge MA, US

Assignee:

Millenium Pharmaceuticals, Inc. - Cambridge MA

International Classification:

G01N 33/50

US Classification:

436 64, 435 6, 435 723, 530350, 5303877, 536 231, 536 235, 536 243

Abstract:

The invention relates to nucleic acid molecules and proteins associated with cervical cancer including pre-malignant conditions such as dysplasia. Compositions, kits, and methods for detecting, characterizing, preventing, and treating human cervical cancers are also provided.

US Patent:

20080286781, Nov 20, 2008

Filed:

Jan 24, 2008

Appl. No.:

12/011459

Inventors:

John E. Monahan - Walpole MA, US
Xumei Zhao - Wayland MA, US
Yan Chen - Acton MA, US
Karen Glatt - Natick MA, US
Shubhangi Kamatkar - Newton MA, US

Assignee:

Millennium Pharmaceuticals, Inc. - Cambridge MA

International Classification:

C12Q 1/68
G01N 33/00
C12N 15/11
C12N 5/06
C07K 16/18
C07K 14/00
C12N 15/00
C12Q 1/02

US Classification:

435 6, 436 64, 435 29, 536 235, 4353201, 435325, 530350, 5303877

Abstract:

The invention relates to nucleic acid molecules and proteins associated with cervical cancer including pre-malignant conditions such as dysplasia. Compositions, kits, and methods for detecting, characterizing, preventing, and treating human cervical cancers are also provided.

US Patent:

20120264625, Oct 18, 2012

Filed:

Oct 14, 2011

Appl. No.:

13/273808

Inventors:

John E. Monahan - Walpole MA, US
Xumei Zhao - Wayland MA, US
Yan Chen - Acton MA, US
Karen Glatt - Natick MA, US
Shubhangi Kamatkar - Newton MA, US

Assignee:

Millennium Pharmaceuticals, Inc. - Cambridge MA

International Classification:

G01N 33/574
G01N 21/76
G01N 21/64
C12Q 1/68
C40B 30/04

US Classification:

506 9, 435 614, 435 792, 436501, 435 612, 435 611

Abstract:

The invention relates to nucleic acid molecules and proteins associated with cervical cancer including pre-malignant conditions such as dysplasia. Compositions, kits, and methods for detecting, characterizing, preventing, and treating human cervical cancers are also provided.