Yan F Chen

US Patent:

20220318519, Oct 6, 2022

Filed:

May 11, 2022

Appl. No.:

17/741945

Inventors:

- Redmond WA, US
Ruihua Song - Beijing, CN
Min Zeng - Redmond WA, US
Yan Chen - Redmond WA, US
Yue Liu - Redmond WA, US

International Classification:

G06F 40/35
G06F 16/332
G06F 16/33

Abstract:

The present disclosure provides a technical solution related to establishing a characterized chatbot with personality. On one hand, a corpus database matched with a specific character may be established, and a generated regular/conventional response messages may be converted into a characterized response messages with character's features during conversation, so that the conversation style of a chatbot may be characterized with a certain character's features. On the other hand, a chatbot may select a response message with a specific emotion by using an emotion conversation table corresponding to a personality when generating the response message against a content of a conversation input by a user, so that a chatbot may be characterized and have certain personality.

US Patent:

20230025491, Jan 26, 2023

Filed:

Jul 21, 2022

Appl. No.:

17/870656

Inventors:

- Bothell WA, US
Yan Chen - Woodinville WA, US
Patrick D. Noble - Seattle WA, US
Vikas Patnaik - Mukilteo WA, US

International Classification:

F23C 7/06
F23C 6/04
F23N 1/00

Abstract:

Combustion systems and associated methods are disclosed herein. In some embodiments, a combustion system comprises a first combustion zone, a second combustion zone downstream of the first combustion zone, and a heat module thermally coupled to the first combustion zone and/or second combustion zone. The first combustion zone is configured to (i) receive and combust preheated air and a first fuel and (ii) generate a first exhaust gas, and the second combustion zone is configured to (i) receive and combust the first exhaust gas and a second fuel and (ii) generate a second exhaust gas. The first exhaust gas can have a first excess air and the second exhaust gas can have a second excess air less than the first excess air. The heat module can comprise a thermionic converter or another heat-to-electricity converter able to generate a power output.

US Patent:

20210324100, Oct 21, 2021

Filed:

Jun 21, 2021

Appl. No.:

17/353648

Inventors:

- Seattle WA, US
- New York NY, US
Rupesh AMIN - Seattle WA, US
Aye CHEN - Seattle WA, US
Kimberly HARRINGTON - Seattle WA, US
Collin HAUSKINS - Seattle WA, US
Erik HESS - Seattle WA, US
Cyr DE IMUS - Seattle WA, US
Jon JONES - Seattle WA, US
Audrey OLSHEFSKY - Seattle WA, US
Stefan PONKO - Seattle WA, US
Ruth SALMON - Seattle WA, US
Semih TAREEN - Seattle WA, US
Rebecca WU - Seattle WA, US
Yan CHEN - Seattle WA, US
Steven M. SHAMAH - Seattle WA, US
Csaba PAZMANY - Seattle WA, US
Jui DUTTA-SIMMONS - Seattle WA, US
Mariana Cota STIRNER - Seattle WA, US
Melissa WORKS - Seattle WA, US

Assignee:

Juno Therapeutics, Inc. - Seattle WA
Memorial Sloan Kettering Cancer Center - New York NY

International Classification:

C07K 16/28
A61K 35/17
C07K 14/725
A61P 35/00
A61K 39/395
C07K 14/705
C12Q 1/6848

Abstract:

Provided herein are chimeric receptors, such as chimeric antigen receptors (CARs), comprising BCMA-binding molecules, such as anti-BCMA antibodies and antigen-binding fragments thereof, such as heavy chain variable (V) regions and single-chain antibody fragments, and encoding polynucleotides. In some embodiments, the anti-BCMA chimeric receptors specifically bind to BCMA. Among the anti-BCMA-binding molecules are human antibodies, including those that compete for binding to BCMA with reference antibodies, such as a non-human reference antibody. Also provided are genetically engineered cells expressing the CARs and uses thereof such as in adoptive cell therapy.

US Patent:

20200392236, Dec 17, 2020

Filed:

Nov 1, 2018

Appl. No.:

16/760411

Inventors:

- Seattle WA, US
Steven M. SHAMAH - Seattle WA, US
Yan CHEN - Seattle WA, US
Rebecca WU - Seattle WA, US
Collin HAUSKINS - Seattle WA, US
Csaba PAZMANY - Seattle WA, US
Jui DUTTA-SIMMONS - Seattle WA, US
Kimberly HARRINGTON - Seattle WA, US

Assignee:

Juno Therapeutics, Inc. - Seattle WA

International Classification:

C07K 16/28
C07K 14/705
C07K 14/535
C12N 15/867
A61P 35/00

Abstract:

Provided herein are BCMA-binding molecules, including anti-BCMA antibodies and antigen-binding fragments thereof such as heavy chain variable (VH) regions and single-chain antibody fragments, and chimeric receptors comprising the anti-BCMA binding molecules such as chimeric antigen receptors (CARs). In some embodiments, the anti-BCMA antibodies or antigen-binding fragments thereof specifically bind to BCMA-1. Among the anti-BCMA antibodies are human antibodies, including those that compete for binding to BCMA with reference antibodies, such as a non-human reference antibody. Also provided are genetically engineered cells expressing the CARs or BCMA-binding molecules and uses thereof such as in adoptive cell therapy.

US Patent:

20200342179, Oct 29, 2020

Filed:

Dec 13, 2018

Appl. No.:

16/765368

Inventors:

- Redmond WA, US
Ruihua Song - Beijing, CN
Min Zeng - Redmond WA, US
Yan Chen - Redmond WA, US
Yue Liu - Redmond WA, US

International Classification:

G06F 40/35
G06F 16/332
G06F 16/33

Abstract:

The present disclosure provides a technical solution related to establishing a characterized chatbot with personality. On one hand, a corpus database matched with a specific character may be established, and a generated regular/conventional response messages may be converted into a characterized response messages with character's features during conversation, so that the conversation style of a chatbot may be characterized with a certain character's features. On the other hand, a chatbot may select a response message with a specific emotion by using an emotion conversation table corresponding to a personality when generating the response message against a content of a conversation input by a user, so that a chatbot may be characterized and have certain personality.