Yan Chen

US Patent:

7285564, Oct 23, 2007

Filed:

Oct 29, 2003

Appl. No.:

10/696464

Inventors:

Mathai Mammen - Redwood Shores CA, US
Richard Wilson - El Sobrante CA, US
Yan Chen - Burlingame CA, US
Sarah Dunham - San Rafael CA, US
Adam Hughes - San Francisco CA, US
Craig Husfeld - Redwood City CA, US
Yu-Hua Ji - Redwood City CA, US
Li Li - Sunnyvale CA, US
Trevor Mischki - Burlingame CA, US
Ioanna Stergiades - San Francisco CA, US

Assignee:

Theravance, Inc. - South San Francisco CA

International Classification:

A61K 31/445
C07D 401/14

US Classification:

514318, 514256, 546193, 544333

Abstract:

This invention provides 4-amino-1-(pyridylmethyl)piperidine and related compounds and pharmaceutically acceptable salts thereof which are useful as muscarinic receptor antagonists. This invention also provides pharmaceutical compositions containing such compounds; processes and intermediates useful for preparing such compounds; and methods for treating disease conditions mediated by muscarinic receptors, such as overactive bladder, irritable bowel syndrome and chronic obstructive pulmonary disease, using such compounds.