Yan Jin Chen

US Patent:

6995174, Feb 7, 2006

Filed:

May 20, 2003

Appl. No.:

10/441657

Inventors:

Xiangdong Alan Wang - Guilford CT, US
Li-Qiang Sun - Glastonbury CT, US
Ny Sin - East Hampton CT, US
Paul Michael Scola - Glastonbury CT, US
Piyasena Hewawasam - Middletown CT, US
Andrew Charles Good - Wallingford CT, US
Yan Chen - Guilford CT, US
Jeffrey Allen Campbell - Cheshire CT, US

Assignee:

Bristol-Myers Squibb Company - Princeton NJ

International Classification:

C07D 215/38
C07D 401/04
C07D 207/46
A61K 31/47
A61K 31/40

US Classification:

514312, 514313, 514314, 514343, 514423, 514422, 546159, 546160, 5462791, 546153, 548537

Abstract:

Hepatitis C virus inhibitors are disclosed having the general formula:.

US Patent:

7449479, Nov 11, 2008

Filed:

Dec 7, 2005

Appl. No.:

11/295914

Inventors:

Xiangdong Alan Wang - Guilford CT, US
Li-Qiang Sun - Glastonbury CT, US
Ny Sin - East Hampton CT, US
Paul Michael Scola - Glastonbury CT, US
Piyasena Hewawasam - Middletown CT, US
Andrew Charles Good - Wallingford CT, US
Yan Chen - Guilford CT, US
Jeffrey Allen Campbell - Cheshire CT, US

Assignee:

Bristol-Myers Squibb Company - Princeton NJ

International Classification:

A61K 31/47
C07D 215/08

US Classification:

514313, 514314, 514312, 514343, 514423, 514422, 546159, 546160, 5462791, 546153, 549537

Abstract:

Hepatitis C virus inhibitors are disclosed having the general formula:Compositions comprising the compounds and methods for using the compounds to inhibit HCV are also disclosed.

US Patent:

7772180, Aug 10, 2010

Filed:

Nov 5, 2007

Appl. No.:

11/934840

Inventors:

Ny Sin - East Hampton CT, US
Brian Lee Venables - Durham CT, US
Li-Qiang Sun - Glastonbury CT, US
Yan Chen - Guilford CT, US
Paul Michael Scola - Glastonbury CT, US

Assignee:

Bristol-Myers Squibb Company - Princeton NJ

International Classification:

A01N 37/18

US Classification:

514 2

Abstract:

Hepatitis C virus inhibitors having the general formula.

US Patent:

7915291, Mar 29, 2011

Filed:

Sep 2, 2008

Appl. No.:

12/202603

Inventors:

Xiangdong Alan Wang - Guilford CT, US
Li-Qiang Sun - Glastonbury CT, US
Ny Sin - East Hampton CT, US
Paul Michael Scola - Glastonbury CT, US
Yan Chen - Guilford CT, US

Assignee:

Bristol-Myers Squibb Company - Princeton NJ

International Classification:

C07D 215/38
A61K 31/04

US Classification:

514312, 514313, 514314, 546159, 546160, 5462791

Abstract:

Hepatitis C virus inhibitors are disclosed having the general formula:.

US Patent:

8299094, Oct 30, 2012

Filed:

Dec 13, 2010

Appl. No.:

12/966175

Inventors:

Xiangdong Alan Wang - Guilford CT, US
Li-Qiang Sun - Glastonbury CT, US
Ny Sin - East Hampton CT, US
Paul Michael Scola - Glastonbury CT, US
Yan Chen - Guilford CT, US

Assignee:

Bristol-Myers Squibb Company - Princeton NJ

International Classification:

C07D 215/38
A61K 31/04

US Classification:

514312, 514313, 514314, 514343, 514423, 514422, 546153, 546154, 546159, 546160, 5462797

Abstract:

Hepatitis C virus inhibitors are disclosed having the general formula:.

US Patent:

20020115621, Aug 22, 2002

Filed:

Aug 1, 2001

Appl. No.:

09/920141

Inventors:

Yan Chen - Guilford CT, US

International Classification:

A61K031/7048
C07H017/08

US Classification:

514/029000, 536/007400

Abstract:

A macrolide antibiotic of the formula wherein the variables are defined as described herein.

US Patent:

20120142653, Jun 7, 2012

Filed:

Jun 2, 2011

Appl. No.:

13/151722

Inventors:

Alicia Regueiro-Ren - Middletown CT, US
Zheng Liu - Beacon Falls CT, US
Jacob Swidorski - Southington CT, US
Nicholas A. Meanwell - East Hampton CT, US
Jie Chen - Madison CT, US
Yan Chen - Guilford CT, US
Ny Sin - East Hampton CT, US

International Classification:

A61K 31/58
A61P 37/00
A61P 31/18
C07J 53/00
A61K 31/56

US Classification:

514176, 540 47, 552514, 514169

Abstract:

Compounds having drug and bio-affecting properties, their pharmaceutical compositions and methods of use are set forth. In particular, modified C-3 and C-28 betulinic acid derivatives that possess unique antiviral activity are provided as HIV maturation inhibitors. These compounds are useful for the treatment of HIV and AIDS.

US Patent:

20130029954, Jan 31, 2013

Filed:

Jan 27, 2012

Appl. No.:

13/359680

Inventors:

Alicia Regueiro-Ren - Middletown CT, US
Jacob Swidorski - Southington CT, US
Yan Chen - Guilford CT, US
Jie Chen - Madison CT, US
Nicholas A. Meanwell - East Hampton CT, US
Zheng Liu - Beacon Falls CT, US

International Classification:

A61K 31/565
A61P 31/18
A61P 31/14
C07J 53/00
A61K 31/58

US Classification:

514173, 552510, 514169, 540 47, 514176, 514172, 540 15

Abstract:

Compounds having drug and bio-affecting properties, their pharmaceutical compositions and methods of use are set forth. In particular, C-28 amines of C-3 modified betulinic acid derivatives that possess unique antiviral activity are provided as HIV maturation inhibitors. These compounds are useful for the treatment of HIV and AIDS. In particular, the following compounds are provided herein, including pharmaceutically acceptable salts thereof:a compound of formula Ia compound of formula IIand a compound of formula III