Yan Xu Chen

US Patent:

7125663, Oct 24, 2006

Filed:

Jun 12, 2002

Appl. No.:

10/171311

Inventors:

Robert Schlegel - Auburndale MA, US
Yan Chen - Cambridge MA, US
Xumei Zhao - Burlington MA, US
John E. Monahan - Walpole MA, US
Shubhangi Kamatkar - Newton MA, US
Manjula Gannavarapu - Acton MA, US
Karen Glatt - Natick MA, US
Sebastian Hoersh - Arlington MA, US

Assignee:

Millenium Pharmaceuticals, Inc. - Cambridge MA

International Classification:

C12Q 1/68

US Classification:

435 6, 435 723, 530350, 5303877, 5303913, 536 235, 536 2431, 436 65

Abstract:

The invention relates to newly discovered nucleic acid molecules and proteins associated with cervical cancer including pre-malignant conditions such as dysplasia. Compositions, kits, and methods for detecting, characterizing, preventing, and treating human cervical cancers are provided.

US Patent:

7644271, Jan 5, 2010

Filed:

Nov 7, 2005

Appl. No.:

11/268232

Inventors:

Mikhail Cherepov - Lexington MA, US
Yan Chen - Boonton Township NJ, US

Assignee:

Cisco Technology, Inc. - San Jose CA

International Classification:

H04L 29/06
G06F 12/14
G06F 12/16

US Classification:

713164, 726 22, 726 23, 726 24

Abstract:

A method and computer program product for providing enforcement of security policies for kernel module loading is presented. File paths for shared library executable files opened by user processes are cached. When a request to load a kernel loadable module (KLM) is received, a previously cached file path for said KLM is retrieved, said file path mapping a location of an executable file from which said KLM was produced. A security policy is applied to said file path, wherein when said file path triggers a security policy rule then an action associated with a triggered rule is taken, and wherein when said file path does not trigger a security policy rule then said KLM request is allowed to proceed.

US Patent:

7846737, Dec 7, 2010

Filed:

Aug 25, 2006

Appl. No.:

11/510530

Inventors:

Robert Schlegel - Auburndale MA, US
Yan Chen - Acton MA, US
Xumei Zhao - Wayland MA, US
John E. Monahan - Walpole MA, US
Shubhangi Kamatkar - Newton MA, US
Manjula Gannavarapu - Acton MA, US
Karen Glatt - Natick MA, US
Sebastian Hoersch - Arlington MA, US

Assignee:

Millennium Pharmaceuticals, Inc. - Cambridge MA

International Classification:

G01N 33/48
G01N 33/574

US Classification:

436 64, 435 6, 435 71, 435 723, 530350, 5303877, 536 235, 536 243

Abstract:

The invention relates to newly discovered nucleic acid molecules and proteins associated with cervical cancer including pre-malignant conditions such as dysplasia. Compositions, kits, and methods for detecting, characterizing, preventing, and treating human cervical cancers are provided.

US Patent:

7847062, Dec 7, 2010

Filed:

Jul 7, 2006

Appl. No.:

11/482641

Inventors:

Yan Chen - Lexington MA, US
Elena Getmanova - Lexington MA, US
Martin C. Wright - Boston MA, US
Alan S. Harris - Andover MA, US
Ai Ching Lim - Mercer Island WA, US
Jochem Gokemeijer - Boston MA, US
Lin Sun - West Roxbury MA, US
Michael Wittekind - Bainbridge Island WA, US

Assignee:

Bristol-Myers Squibb Company - Princeton NJ

International Classification:

C07K 14/78
A61K 38/39

US Classification:

530320, 530345, 530350, 530402, 514 12

Abstract:

The present disclosure relates to novel vascular endothelial growth factor receptor (VEGFR)-binding polypeptides and methods for using these polypeptides to inhibit biological activities mediated by vascular endothelial growth factors (VEGFs). The present disclosure also provides various improvements relating to single domain binding polypeptides.

US Patent:

7858739, Dec 28, 2010

Filed:

Jun 5, 2006

Appl. No.:

11/448171

Inventors:

Yan Chen - Lexington MA, US
Elena Getmanova - Lexington MA, US
Martin C. Wright - Boston MA, US
Alan S. Harris - Andover MA, US
Ai Ching Lim - Newton MA, US
Jochem Gokemeijer - Arlington MA, US
Lin Sun - West Roxbury MA, US
Michael Wittekind - Bainbridge Island WA, US

Assignee:

Bristol-Myers Squibb Company - Princeton NJ

International Classification:

C07K 14/78
A61K 38/39

US Classification:

530324, 530345, 530350, 530402, 514 12

Abstract:

The present disclosure relates to novel vascular endothelial growth factor receptor (VEGFR)-binding polypeptides and methods for using these polypeptides to inhibit biological activities mediated by vascular endothelial growth factors (VEGFs). The present disclosure also provides various improvements relating to single domain binding polypeptides.

US Patent:

8062892, Nov 22, 2011

Filed:

Jun 14, 2010

Appl. No.:

12/814849

Inventors:

Robert Schlegel - Auburndale MA, US
Yan Chen - Acton MA, US
Xumei Zhao - Wayland MA, US
John E. Monahan - Walpole MA, US
Shubhangi Kamatkar - Newton MA, US
Manjula Gannavarapu - Acton MA, US
Karen Glatt - Natick MA, US
Sebastian Hoersch - Arlington MA, US

Assignee:

Millennium Pharmaceuticals, Inc. - Cambridge MA

International Classification:

G01N 33/48
G01N 33/574

US Classification:

436 64, 435 6, 435 71, 435 723, 530350, 5303877, 536 235, 536 243

Abstract:

The invention relates to newly discovered nucleic acid molecules and proteins associated with cervical cancer including pre-malignant conditions such as dysplasia. Compositions, kits, and methods for detecting, characterizing, preventing, and treating human cervical cancers are provided.

US Patent:

8324362, Dec 4, 2012

Filed:

May 26, 2010

Appl. No.:

12/788240

Inventors:

Yan Chen - Lexington MA, US
Elena Getmanova - Lexington MA, US
Martin C. Wright - Boston MA, US
Alan S. Harris - Andover MA, US
Ai Ching Lim - Newton MA, US
Jochem Gokemeijer - Arlington MA, US
Lin Sun - West Roxbury MA, US
Michael Wittekind - Bainbridge Island WA, US

Assignee:

Bristol-Myers Squibb Company - Princeton NJ

International Classification:

C07H 21/04
C12N 15/63
C12N 15/09
C12N 1/21
C12N 1/15
C12N 5/10
A61K 38/39
C07K 14/78
A61P 35/00

US Classification:

536 235, 435 691, 4352523, 4352542, 4353201, 435348, 435354, 435358, 435364, 435365, 514 93, 514 133, 530324

Abstract:

The present disclosure relates to novel vascular endothelial growth factor receptor (VEGFR)-binding polypeptides and methods for using these polypeptides to inhibit biological activities mediated by vascular endothelial growth factors (VEGFs). The present disclosure also provides various improvements relating to single domain binding polypeptides.

US Patent:

8609613, Dec 17, 2013

Filed:

Jul 18, 2012

Appl. No.:

13/552398

Inventors:

Yan Chen - Lexington MA, US
Elena Getmanova - Lexington MA, US
Martin C. Wright - Boston MA, US
Alan S. Harris - Andover MA, US
Ai Ching Lim - Newton MA, US
Jochem Gokemeijer - Boston MA, US
Lin Sun - West Roxbury MA, US
Michael Wittekind - Bainbridge Island WA, US

Assignee:

Bristol-Myers Squibb Company - Princeton NJ

International Classification:

A61K 38/39
A61P 29/00
A61P 35/00
A61P 19/02
C07K 14/78
C07K 14/475
C07K 14/705

US Classification:

514 81, 514 93, 514 122, 514 133, 514 166, 514 192, 514 208, 530324, 530345, 530350, 530402

Abstract:

The present disclosure relates to novel vascular endothelial growth factor receptor (VEGFR)-binding polypeptides and methods for using these polypeptides to inhibit biological activities mediated by vascular endothelial growth factors (VEGFs). The present disclosure also provides various improvements relating to single domain binding polypeptides.