Yan Y Chen

US Patent:

20210131308, May 6, 2021

Filed:

Nov 4, 2019

Appl. No.:

16/673141

Inventors:

- Farmington CT, US
Goran Djuknic - New York NY, US
Yan Chen - South Windsor CT, US

International Classification:

F01D 25/16
F16C 19/52

Abstract:

A bearing assembly monitoring system includes a bearing assembly supporting rotation of a rotating member. The bearing assembly includes a fixed portion and rotatable portion. A piezoelectric element is mounted to the fixed portion and generates an electric signal in response to a vibration of the fixed portion. A first transceiver is electrically coupled to the piezoelectric element to receive the electrical signal generated by the piezoelectric element and generate a signal indicative of the vibration of the fixed portion. A gas turbine engine bearing monitoring system and a method are also disclosed.

US Patent:

20200390776, Dec 17, 2020

Filed:

Nov 5, 2018

Appl. No.:

16/761449

Inventors:

- Princeton NJ, US
Yan Chen - Yardley PA, US
Bireshwar Dasgupta - Doylestown PA, US
Andrew P. Degnan - Jamison PA, US
Matthew D. Hill - Windham NH, US
Godwin Kwame Kumi - Morrisville PA, US
Harold A. Mastalerz - Guilford CT, US
Mark D. Wittman - Hopkinton MA, US
Bradley C. Pearce - East Hampton CT, US
Guifen Zhang - Hopkinton MA, US

International Classification:

A61K 31/5377
A61K 45/06
A61K 31/506
C07D 405/14
C07D 405/12
C07D 413/14
C07D 453/02
C07D 498/10
C07D 491/048
C07D 519/00
A61P 35/00

Abstract:

Disclosed are compounds of Formula (I) or a salt thereof, wherein: X is CH or N; Y is CR5 or N; and R1, R2, R3, R4, and R5 are defined herein. Also disclosed are methods of using such compounds to modulate or inhibit the enzymatic activity of hematopoietic progenitor kinase 1 (HPK1), and pharmaceutical compositions comprising such compounds. These compounds are useful in the treatment of viral infections and proliferative disorders, such as cancer.

US Patent:

20200191730, Jun 18, 2020

Filed:

Nov 21, 2019

Appl. No.:

16/690490

Inventors:

- Stratford CT, US
Yan Chen - Stratford CT, US
Timothy Ely - Stratford CT, US
Chester Lowe - Stratford CT, US
Roberto Velasco - Stratford CT, US

International Classification:

G01N 23/046
G01N 23/044

Abstract:

The aspects of the present disclosure are directed to a method and system for producing tomosynthesis images of a breast specimen with the capability of attaining images with geometric magnification. In one embodiment, an x-ray source delivers x-rays through a specimen of excised tissue and forms an image at a digital x-ray detector with the resultant image enlarging as the specimen is moved closer to the x-ray source. Multiple x-ray images are taken as the x-ray source moves relative to the stationary breast specimen. The source may travel substantially along a path while the detector remains stationary throughout and the source remains substantially equidistant from the specimen platform. The set of x-ray image data taken at the different points are combined to form a tomosynthesis image that can be viewed in different formats, alone or as an adjunct to conventional specimen radiography.

US Patent:

20200182807, Jun 11, 2020

Filed:

Dec 10, 2019

Appl. No.:

16/708963

Inventors:

- Stratford CT, US
Yan Chen - STRATFORD CT, US
Chester Lowe - STRATFORD CT, US
Roberto Velasco - STRATFORD CT, US
Peter Yasutake - STRATFORD CT, US

International Classification:

G01N 23/044
G01N 23/083
G01N 23/20025

Abstract:

The present disclosure relates to the field of a cabinet x-ray incorporating a stationary x-ray source array, and an x-ray detector, for the production of organic and non-organic images. Stationary x-ray digital cabinet tomosynthesis systems and related methods are disclosed. According to one aspect, the subject matter described herein can include an x-ray tomosynthesis system having a plurality of stationary field emission x-ray sources configured to irradiate a location for positioning an object to be imaged with x-ray beams to generate projection images of the object. An x-ray detector can be configured to detect the projection images of the object. A projection image reconstruction function can be configured to reconstruct tomography images of the object based on the projection images of the object. In the preferred embodiment, the x-ray source or sources are statically affixed in a range from about 350 to and including about 10.

US Patent:

20190269376, Sep 5, 2019

Filed:

Feb 28, 2019

Appl. No.:

16/288421

Inventors:

- Stratford CT, US
Yan Chen - Stratford CT, US
Chester Lowe - Stratford CT, US
Roberto Velasco - Stratford CT, US
Peter Yasutake - Stratford CT, US

International Classification:

A61B 6/00
A61B 6/02
A61B 6/10

Abstract:

The present disclosure relates to the field of a cabinet x-ray incorporating an x-ray tube, an x-ray detector, and a real-time camera, either High Definition or Standard Resolution, for the production of organic and non-organic images. The computing device receives video data from the real-time camera and the x-ray detector and creates, based on the video data, a superimposed image of the captured x-ray image with the captured real-time image. In particular, the disclosure relates to a system and method with corresponding apparatus for capturing a real-time image simultaneously with the x-ray image allowing a cabinet x-ray unit to display a superimposed image of the two images and optimizes the images to result in a superimposed image with exact orientation of the 2 images and overlaying the 2 images on the display.

US Patent:

20190187073, Jun 20, 2019

Filed:

Feb 22, 2019

Appl. No.:

16/282914

Inventors:

- Strafford CT, US
Yan Chen - Stratford CT, US
Timothy Ely - Stratford CT, US
Chester Lowe - Stratford CT, US
Roberto Velasco - Stratford CT, US

International Classification:

G01N 23/044
G06T 11/00

Abstract:

The present disclosure relates to the field of a cabinet x-ray incorporating an x-ray tube, an x-ray detector, and a real-time camera, either high definition or standard resolution, for the production of organic and non-organic images. The computing device can receive video data from the camera and the x-ray detector and determines, based on the video data, an overlay of the captured x-ray image with the captured real-time image or display images adjacently i.e. Picture-In-Picture (PIP). In particular, the disclosure relates to a system and method with corresponding apparatus for capturing a real-time image simultaneously with the x-ray image allowing a cabinet x-ray unit to attain and optimize images with exact orientation of the 2 images.

US Patent:

20190053771, Feb 21, 2019

Filed:

Aug 16, 2018

Appl. No.:

15/999113

Inventors:

- Stratford CT, US
Yan Chen - Stratford CT, US
Chester Lowe - Stratford CT, US
Roberto Velasco - Stratford CT, US

International Classification:

A61B 6/02
A61B 6/03
A61B 6/00

Abstract:

The present disclosure relates to the field of a cabinet x-ray incorporating an x-ray tube, an x-ray detector, and an optical camera for the production of organic and non-organic images. The computing device receives data including video data from an optical camera, a laser detector, an infrared detector, an ultrasonic detector, or a weight scale or pressure sensor, and determines automatically, based on the resultant data, if a sample/specimen has been left in the sample chamber. In particular, the disclosure relates to a system and method with corresponding apparatus for automatic detection if a sample/specimen has been left in the sample chamber without having to open the chamber door.

US Patent:

20180275076, Sep 27, 2018

Filed:

Mar 26, 2018

Appl. No.:

15/935358

Inventors:

- Stratford CT, US
Yan Chen - Stratford CT, US
Timothy Ely - Stratford CT, US
Chester Lowe - Stratford CT, US
Roberto Velasco - Stratford CT, US

International Classification:

G01N 23/044
G06T 11/00

Abstract:

The present disclosure relates to the field of a cabinet x-ray incorporating an x-ray tube, an x-ray detector, and a real-time camera, either high definition or standard resolution, for the production of organic and non-organic images. The computing device can receive video data from the camera and the x-ray detector and determines, based on the video data, an overlay of the captured x-ray image with the captured real-time image or display images adjacently i.e. Picture-In-Picture (PIP). In particular, the disclosure relates to a system and method with corresponding apparatus for capturing a real-time image simultaneously with the x-ray image allowing a cabinet x-ray unit to attain and optimize images with exact orientation of the 2 images.