Yan Chen

US Patent:

7560112, Jul 14, 2009

Filed:

Apr 28, 2006

Appl. No.:

11/413561

Inventors:

Yan Chen - Wayne PA, US
Debra Gardner - Bear DE, US
David M. Knight - Berwyn PA, US
Michael W. Lark - Devon PA, US
Bailin Liang - Gilbertsville PA, US
David J. Shealy - Downingtown PA, US
Xiao-Yu R. Song - West Chester PA, US
Raymond W. Sweet - Bryn Mawr PA, US
Susan H. Tam - Boothwyn PA, US
Sheng-Jiun Wu - Broomall PA, US
Jing Yang - Ambler PA, US
David Matthew Marquis - Encinitas CA, US
Eric Michael Smith - San Diego CA, US
Alain Philippe Vasserot - Carlsbad CA, US

Assignee:

Applied Molecular Evolution, Inc. - San Diego CA
Centocor Ortho Biotech Inc. - Malvern PA

International Classification:

A61K 39/395
C07K 16/24
C12N 5/12

US Classification:

4241391, 53038823, 435326

Abstract:

An anti-IL-6 antibody, including isolated nucleic acids that encode at least one anti-IL-6 antibody, vectors, host cells, transgenic animals or plants, and methods of making and using thereof have applications in diagnostic and/or therapeutic compositions, methods and devices.

US Patent:

7833755, Nov 16, 2010

Filed:

May 22, 2009

Appl. No.:

12/470753

Inventors:

Yan Chen - Wayne PA, US
Debra Gardner - Bear DE, US
David M. Knight - Berwyn PA, US
Michael W. Lark - Devon PA, US
Bailin Liang - Gilbertsville PA, US
David J. Shealy - Downingtown PA, US
Xiao-Yu R. Song - West Chester PA, US
Raymond W. Sweet - Bryn Mawr PA, US
Susan H. Tam - Boothwyn PA, US
Sheng-Jiun Wu - Broomall PA, US
Jing Yang - Ambler PA, US
David Matthew Marquis - Encinitas CA, US
Eric Michael Smith - San Diego CA, US
Alain Philippe Vasserot - Carlsbad CA, US

International Classification:

C12N 5/10
C12N 15/13
C12N 15/63

US Classification:

435 696, 536 2353, 4352523, 4353201, 435325

Abstract:

Anti-IL-6 antibody nucleic acids, vectors, host cells, transgenic animals or plants, and methods of making and using thereof have applications in diagnostic and/or therapeutic compositions, methods and devices.

US Patent:

8067003, Nov 29, 2011

Filed:

Oct 8, 2010

Appl. No.:

12/901200

Inventors:

Yan Chen - Wayne PA, US
Debra Gardner - Bear DE, US
David M. Knight - Berwyn PA, US
Michael W. Lark - Devon PA, US
Bailin Liang - Gilbertsville PA, US
David J. Shealy - Downingtown PA, US
Xiao-Yu R. Song - West Chester PA, US
Raymond W. Sweet - Bryn Mawr PA, US
Susan H. Tam - Boothwyn PA, US
Sheng-Jiun Wu - Broomall PA, US
Jing Yang - Ambler PA, US
David Matthew Marquis - Encinitas CA, US
Eric Michael Smith - San Diego CA, US
Alain Philippe Vasserot - Carlsbad CA, US

Assignee:

Centocor, Inc. - Malvern PA
Applied Molecular Evolution, Inc. - San Diego CA

International Classification:

A61K 39/395

US Classification:

4241451, 4241301, 4241411

Abstract:

Anti-IL-6 antibodies are used to treat IL-6 related conditions, such as rheumatoid arthritis, osteoarthritis, osteolysis, aseptic loosening of orthopedic implants, systemic lupus erythematosus, cutaneous lupus erythematosus, lupus nephritis, type 2 diabetes mellitus, chronic obstructive pulmonary disease, and renal cell carcinoma.

US Patent:

8226611, Jul 24, 2012

Filed:

Oct 27, 2011

Appl. No.:

13/283177

Inventors:

Yan Chen - Wayne PA, US
Debra Gardner - Bear DE, US
David M. Knight - Berwyn PA, US
Michael W. Lark - Devon PA, US
Bailin Liang - Gilbertsville PA, US
David J. Shealy - Downingtown PA, US
Xiao-Yu R. Song - West Chester PA, US
Raymond W. Sweet - Bryn Mawr PA, US
Susan H. Tam - Boothwyn PA, US
Sheng-Jiun Wu - Broomall PA, US
Jing Yang - Ambler PA, US
David Matthew Marquis - Encinitas CA, US
Eric Michael Smith - San Diego CA, US
Alain Philippe Vasserot - Carlsbad CA, US

Assignee:

Janssen Biotech, Inc. - Horsham PA
Applied Molecular Evolution - San Diego CA

International Classification:

A61M 37/00
A61M 5/32
A61K 39/395
C07K 16/24

US Classification:

604143, 604198, 4241391, 53038823

Abstract:

An anti-IL-6 antibody, including isolated nucleic acids that encode at least one anti-IL-6 antibody, vectors, host cells, transgenic animals or plants, and methods of making and using thereof have applications in diagnostic and/or therapeutic compositions, methods and devices.

US Patent:

8623362, Jan 7, 2014

Filed:

Jun 15, 2012

Appl. No.:

13/524684

Inventors:

Yan Chen - Wayne PA, US
Debra Gardner - Bear DE, US
David M. Knight - Berwyn PA, US
Michael W. Lark - Devon PA, US
Bailin Liang - Gilbertsville PA, US
David J. Shealy - Downingtown PA, US
Xiao-Yu R. Song - West Chester PA, US
Raymond W. Sweet - Bryn Mawr PA, US
Susan H. Tam - Boothwyn PA, US
Sheng-Jiun Wu - Broomall PA, US
Jing Yang - Ambler PA, US
David Matthew Marquis - Encinitas CA, US
Eric Michael Smith - San Diego CA, US
Alain Philippe Vasserot - Carlsbad CA, US

Assignee:

Janssen Biotech, Inc. - Horsham PA
Applied Molecular Evolution - San Diego CA

International Classification:

A61K 39/395

US Classification:

4241391, 4241411

Abstract:

An anti-IL-6 antibody, including isolated nucleic acids that encode at least one anti-IL-6 antibody, vectors, host cells, transgenic animals or plants, and methods of making and using thereof have applications in diagnostic and/or therapeutic compositions, methods and devices.

US Patent:

20210131308, May 6, 2021

Filed:

Nov 4, 2019

Appl. No.:

16/673141

Inventors:

- Farmington CT, US
Goran Djuknic - New York NY, US
Yan Chen - South Windsor CT, US

International Classification:

F01D 25/16
F16C 19/52

Abstract:

A bearing assembly monitoring system includes a bearing assembly supporting rotation of a rotating member. The bearing assembly includes a fixed portion and rotatable portion. A piezoelectric element is mounted to the fixed portion and generates an electric signal in response to a vibration of the fixed portion. A first transceiver is electrically coupled to the piezoelectric element to receive the electrical signal generated by the piezoelectric element and generate a signal indicative of the vibration of the fixed portion. A gas turbine engine bearing monitoring system and a method are also disclosed.

US Patent:

20200390776, Dec 17, 2020

Filed:

Nov 5, 2018

Appl. No.:

16/761449

Inventors:

- Princeton NJ, US
Yan Chen - Yardley PA, US
Bireshwar Dasgupta - Doylestown PA, US
Andrew P. Degnan - Jamison PA, US
Matthew D. Hill - Windham NH, US
Godwin Kwame Kumi - Morrisville PA, US
Harold A. Mastalerz - Guilford CT, US
Mark D. Wittman - Hopkinton MA, US
Bradley C. Pearce - East Hampton CT, US
Guifen Zhang - Hopkinton MA, US

International Classification:

A61K 31/5377
A61K 45/06
A61K 31/506
C07D 405/14
C07D 405/12
C07D 413/14
C07D 453/02
C07D 498/10
C07D 491/048
C07D 519/00
A61P 35/00

Abstract:

Disclosed are compounds of Formula (I) or a salt thereof, wherein: X is CH or N; Y is CR5 or N; and R1, R2, R3, R4, and R5 are defined herein. Also disclosed are methods of using such compounds to modulate or inhibit the enzymatic activity of hematopoietic progenitor kinase 1 (HPK1), and pharmaceutical compositions comprising such compounds. These compounds are useful in the treatment of viral infections and proliferative disorders, such as cancer.