Yan Chen

US Patent:

7125663, Oct 24, 2006

Filed:

Jun 12, 2002

Appl. No.:

10/171311

Inventors:

Robert Schlegel - Auburndale MA, US
Yan Chen - Cambridge MA, US
Xumei Zhao - Burlington MA, US
John E. Monahan - Walpole MA, US
Shubhangi Kamatkar - Newton MA, US
Manjula Gannavarapu - Acton MA, US
Karen Glatt - Natick MA, US
Sebastian Hoersh - Arlington MA, US

Assignee:

Millenium Pharmaceuticals, Inc. - Cambridge MA

International Classification:

C12Q 1/68

US Classification:

435 6, 435 723, 530350, 5303877, 5303913, 536 235, 536 2431, 436 65

Abstract:

The invention relates to newly discovered nucleic acid molecules and proteins associated with cervical cancer including pre-malignant conditions such as dysplasia. Compositions, kits, and methods for detecting, characterizing, preventing, and treating human cervical cancers are provided.

US Patent:

7365154, Apr 29, 2008

Filed:

Jun 22, 2004

Appl. No.:

10/873848

Inventors:

David Shealy - Downingtown PA, US
Sam Wu - Broomall PA, US
Yan Chen - Wayne PA, US
Audrey Baker - Philadelphia PA, US

Assignee:

Centocor, Inc. - Malvern PA

International Classification:

A61K 38/04

US Classification:

530327

Abstract:

The invention concerns antagonists of alphav-containing integrins which have therapeutic activity in oncology applications and methods for selecting such antagonists using a peptide which competes for alphaV-integrin binding with a known monoclonal antibody having demonstrated anti-tumor activity. The claimed peptide represents a conformational epitope or mimotope present on the ligand to which the therapeutic antibodies selectively bind.

US Patent:

7560112, Jul 14, 2009

Filed:

Apr 28, 2006

Appl. No.:

11/413561

Inventors:

Yan Chen - Wayne PA, US
Debra Gardner - Bear DE, US
David M. Knight - Berwyn PA, US
Michael W. Lark - Devon PA, US
Bailin Liang - Gilbertsville PA, US
David J. Shealy - Downingtown PA, US
Xiao-Yu R. Song - West Chester PA, US
Raymond W. Sweet - Bryn Mawr PA, US
Susan H. Tam - Boothwyn PA, US
Sheng-Jiun Wu - Broomall PA, US
Jing Yang - Ambler PA, US
David Matthew Marquis - Encinitas CA, US
Eric Michael Smith - San Diego CA, US
Alain Philippe Vasserot - Carlsbad CA, US

Assignee:

Applied Molecular Evolution, Inc. - San Diego CA
Centocor Ortho Biotech Inc. - Malvern PA

International Classification:

A61K 39/395
C07K 16/24
C12N 5/12

US Classification:

4241391, 53038823, 435326

Abstract:

An anti-IL-6 antibody, including isolated nucleic acids that encode at least one anti-IL-6 antibody, vectors, host cells, transgenic animals or plants, and methods of making and using thereof have applications in diagnostic and/or therapeutic compositions, methods and devices.

US Patent:

7644271, Jan 5, 2010

Filed:

Nov 7, 2005

Appl. No.:

11/268232

Inventors:

Mikhail Cherepov - Lexington MA, US
Yan Chen - Boonton Township NJ, US

Assignee:

Cisco Technology, Inc. - San Jose CA

International Classification:

H04L 29/06
G06F 12/14
G06F 12/16

US Classification:

713164, 726 22, 726 23, 726 24

Abstract:

A method and computer program product for providing enforcement of security policies for kernel module loading is presented. File paths for shared library executable files opened by user processes are cached. When a request to load a kernel loadable module (KLM) is received, a previously cached file path for said KLM is retrieved, said file path mapping a location of an executable file from which said KLM was produced. A security policy is applied to said file path, wherein when said file path triggers a security policy rule then an action associated with a triggered rule is taken, and wherein when said file path does not trigger a security policy rule then said KLM request is allowed to proceed.

US Patent:

7833755, Nov 16, 2010

Filed:

May 22, 2009

Appl. No.:

12/470753

Inventors:

Yan Chen - Wayne PA, US
Debra Gardner - Bear DE, US
David M. Knight - Berwyn PA, US
Michael W. Lark - Devon PA, US
Bailin Liang - Gilbertsville PA, US
David J. Shealy - Downingtown PA, US
Xiao-Yu R. Song - West Chester PA, US
Raymond W. Sweet - Bryn Mawr PA, US
Susan H. Tam - Boothwyn PA, US
Sheng-Jiun Wu - Broomall PA, US
Jing Yang - Ambler PA, US
David Matthew Marquis - Encinitas CA, US
Eric Michael Smith - San Diego CA, US
Alain Philippe Vasserot - Carlsbad CA, US

International Classification:

C12N 5/10
C12N 15/13
C12N 15/63

US Classification:

435 696, 536 2353, 4352523, 4353201, 435325

Abstract:

Anti-IL-6 antibody nucleic acids, vectors, host cells, transgenic animals or plants, and methods of making and using thereof have applications in diagnostic and/or therapeutic compositions, methods and devices.

US Patent:

7846737, Dec 7, 2010

Filed:

Aug 25, 2006

Appl. No.:

11/510530

Inventors:

Robert Schlegel - Auburndale MA, US
Yan Chen - Acton MA, US
Xumei Zhao - Wayland MA, US
John E. Monahan - Walpole MA, US
Shubhangi Kamatkar - Newton MA, US
Manjula Gannavarapu - Acton MA, US
Karen Glatt - Natick MA, US
Sebastian Hoersch - Arlington MA, US

Assignee:

Millennium Pharmaceuticals, Inc. - Cambridge MA

International Classification:

G01N 33/48
G01N 33/574

US Classification:

436 64, 435 6, 435 71, 435 723, 530350, 5303877, 536 235, 536 243

Abstract:

The invention relates to newly discovered nucleic acid molecules and proteins associated with cervical cancer including pre-malignant conditions such as dysplasia. Compositions, kits, and methods for detecting, characterizing, preventing, and treating human cervical cancers are provided.

US Patent:

7847062, Dec 7, 2010

Filed:

Jul 7, 2006

Appl. No.:

11/482641

Inventors:

Yan Chen - Lexington MA, US
Elena Getmanova - Lexington MA, US
Martin C. Wright - Boston MA, US
Alan S. Harris - Andover MA, US
Ai Ching Lim - Mercer Island WA, US
Jochem Gokemeijer - Boston MA, US
Lin Sun - West Roxbury MA, US
Michael Wittekind - Bainbridge Island WA, US

Assignee:

Bristol-Myers Squibb Company - Princeton NJ

International Classification:

C07K 14/78
A61K 38/39

US Classification:

530320, 530345, 530350, 530402, 514 12

Abstract:

The present disclosure relates to novel vascular endothelial growth factor receptor (VEGFR)-binding polypeptides and methods for using these polypeptides to inhibit biological activities mediated by vascular endothelial growth factors (VEGFs). The present disclosure also provides various improvements relating to single domain binding polypeptides.

US Patent:

7858739, Dec 28, 2010

Filed:

Jun 5, 2006

Appl. No.:

11/448171

Inventors:

Yan Chen - Lexington MA, US
Elena Getmanova - Lexington MA, US
Martin C. Wright - Boston MA, US
Alan S. Harris - Andover MA, US
Ai Ching Lim - Newton MA, US
Jochem Gokemeijer - Arlington MA, US
Lin Sun - West Roxbury MA, US
Michael Wittekind - Bainbridge Island WA, US

Assignee:

Bristol-Myers Squibb Company - Princeton NJ

International Classification:

C07K 14/78
A61K 38/39

US Classification:

530324, 530345, 530350, 530402, 514 12

Abstract:

The present disclosure relates to novel vascular endothelial growth factor receptor (VEGFR)-binding polypeptides and methods for using these polypeptides to inhibit biological activities mediated by vascular endothelial growth factors (VEGFs). The present disclosure also provides various improvements relating to single domain binding polypeptides.