Yan Wang Li

US Patent:

8304526, Nov 6, 2012

Filed:

Jul 2, 2010

Appl. No.:

12/829651

Inventors:

Mien-Chie Hung - Houston TX, US
Yan Li - Houston TX, US
Yong Wen - Burlingame CA, US

Assignee:

The Board of Regents of the University of Texas System - Austin TX

International Classification:

C07H 21/04

US Classification:

536 235

Abstract:

The present invention regards mutant forms of Bik that comprise anti-cell proliferation and/or pro-apoptotic activities. In particular embodiments, the Bik polypeptides comprise a substitution at Thr33 and Ser35 and, in some embodiments, phosphorylation at these sites is inhibited. In more particular embodiments, these forms are useful for cancer therapy, particularly when administered in combination with liposomes. In embodiments wherein a mutant Bik polynucleotide is administered for cancer therapy, the polynucleotide may be regulated in a tissue-specific manner.

US Patent:

8426574, Apr 23, 2013

Filed:

May 28, 2010

Appl. No.:

12/790618

Inventors:

David Wang - St. Louis MO, US
Guoyan Zhao - St. Louis MO, US
Stacy Finkbeiner - St. Louis MO, US
Jan Vinje - Decatur GA, US
Yan Li - Tucker GA, US
Suxiang Tong - Duluth GA, US

Assignee:

Washington University - St. Louis MO
The United States of America, as Represented by the Secretary of the Department of Health and Human Services, Centers for Disease Control and Prevention - Washington DC

International Classification:

C07H 21/00
C12Q 1/70
A61K 39/12

US Classification:

536 2372, 435 5, 4242041

Abstract:

Provided herein is a novel human astrovirus, its nucleic acid sequence, as well as methods to detect and diagnose the presence of the astrovirus.

US Patent:

20050118154, Jun 2, 2005

Filed:

Apr 2, 2004

Appl. No.:

10/816698

Inventors:

Mien-Chie Hung - Houston TX, US
Yan Li - Houston TX, US
Yong Wen - South San Francisco CA, US

International Classification:

A61K048/00
G01N033/53
G01N033/567
A61K038/53
C12N009/99

US Classification:

424094500, 435184000, 514044000

Abstract:

The present invention regards mutant forms of Bik that comprise anti-cell proliferation and/or pro-apoptotic activities. In particular embodiments, the Bik polypeptides comprise a substitution at Thr33 and Ser35 and, in some embodiments, phosphorylation at these sites is inhibited. In more particular embodiments, these forms are useful for cancer therapy, particularly when administered in combination with liposomes. In embodiments wherein a mutant Bik polynucleotide is administered for cancer therapy, the polynucleotide may be regulated in a tissue-specific manner.

US Patent:

20090075885, Mar 19, 2009

Filed:

Jul 28, 2008

Appl. No.:

12/180730

Inventors:

Mien-Chie Hung - Houston TX, US
Yan Li - Houston TX, US
Yong Wen - Burlingame CA, US

International Classification:

A61K 38/00
A61P 31/00

US Classification:

514 12

Abstract:

The present invention regards mutant forms of Bik that comprise anti-cell proliferation and/or pro-apoptotic activities. In particular embodiments, the Bik polypeptides comprise a substitution at Thr33 and Ser35 and, in some embodiments, phosphorylation at these sites is inhibited. In more particular embodiments, these forms are useful for cancer therapy, particularly when administered in combination with liposomes. In embodiments wherein a mutant Bik polynucleotide is administered for cancer therapy, the polynucleotide may be regulated in a tissue-specific manner.

US Patent:

20220292338, Sep 15, 2022

Filed:

Mar 9, 2021

Appl. No.:

17/195755

Inventors:

- San Ramon CA, US
- Los Alamos NM, US
Yan Li - Houston TX, US
Margaretha Catharina Maria Rijken - Houston TX, US
Velimir Valentinov Vesselinov - Los Alamos NM, US

International Classification:

G06N 3/08
G06N 3/04

Abstract:

A computer implemented method for prediction of geomechanical performance including productivity index decline and completion integrity for a well or a hydrocarbon reservoir using a geomechanics informed machine intelligence (GIMI) algorithm. The method includes running a geomechanical reservoir simulator to generate training datasets for the hydrocarbon reservoir and incorporating physical models and identified variables into the GIMI algorithm. The method further includes training a neural network of the GIMI algorithm by using correlated training datasets that correlate to the physical models to produce a resulting prediction model and performing sensitivity analysis on the resulting prediction model. Additionally, the method includes identifying dominant variables for damage mechanisms through design of experiment statistics and performing history matching and blind test on the resulting prediction model. Lastly, the method includes updating the identified variables and models incorporated into the GIMI algorithm.

US Patent:

20210096277, Apr 1, 2021

Filed:

Sep 25, 2020

Appl. No.:

17/033155

Inventors:

- San Ramon CA, US
Yan LI - Bellaire TX, US
Yunhui TAN - Katy TX, US
Ruiting WU - Sugar Land TX, US
Margaretha Catharina Maria RIJKEN - Houston TX, US
Amr Said EL-FAYOUMI - Houston TX, US
Pietro VALSECCHI - Duesseldorf, DE

Assignee:

CHEVRON U.S.A.INC. - San Ramon CA

International Classification:

G01V 99/00
E21B 47/06
G06F 30/20

Abstract:

Embodiments of evaluating production performance for a wellbore while accounting for subterranean reservoir geomechanics and wellbore completion are provided. One embodiment includes generating the wellbore model; defining geomechanical properties for the subterranean reservoir in the near wellbore region and the far field region, and completion variables for the wellbore completion; and simulating fluid flow in the near wellbore region, the far field region, and the wellbore completion to evaluate production performance for the wellbore over a period of time. A permeability of the subterranean reservoir and a contact area between the wellbore and the subterranean reservoir are updated during simulation over the period of time. The permeability and the contact area are updated as a function of a change in pressure and the geomechanical properties for the subterranean reservoir in the near wellbore region and the far field region, the completion variables for the wellbore completion, or any combination thereof.

US Patent:

20200306664, Oct 1, 2020

Filed:

Jun 27, 2017

Appl. No.:

16/313666

Inventors:

- Atlanta GA, US
Yan LI - Atlanta GA, US
Maksim M. KVETNY - Decatur GA, US

International Classification:

B01D 9/00
C30B 30/02
C30B 7/12

Abstract:

Disclosed herein are systems and methods for the controlled crystallization of a compound. The controlled crystallization is achieved by applying an electric field across solutions of target compound and precipitant, whereby the electric field controls the rate of mixing.

US Patent:

20190391065, Dec 26, 2019

Filed:

Jun 25, 2019

Appl. No.:

16/452111

Inventors:

- San Ramon CA, US
Yan LI - Bellaire TX, US
Karim Shafik ZAKI - Houston TX, US
Wade H. WILLIAMS - Cypress TX, US
Ruiting WU - Sugar Land TX, US
Yunhui TAN - Houston TX, US
MARGARETHA Catharina Maria RIJKEN - Houston TX, US
Russell Thomas EWY - San Ramon CA, US

International Classification:

G01N 15/08
G01N 33/24

Abstract:

In some embodiments, a system includes a housing having a cavity defined therein for holding a test sample, a first inlet in fluid communication with the cavity to deliver fluid to the test sample, a second inlet in fluid communication with the cavity to deliver fluid to the test sample, the first inlet configured to deliver fluid to the test sample in a direction substantially perpendicular to a direction that the second inlet is configured to deliver fluid to the test sample, an outlet in fluid communication with the cavity to receive fluid from the test sample, and a force applicator configured to apply compressive force to the test sample within the cavity. The force applicator forms a seal with the housing while applying compressive force to the test sample. The system also comprises at least one sensor configured to, while fluid flows from at least one of the inlets through the test sample to the outlet, determine a fluid characteristic, a test sample characteristic, or any combination thereof.