Yasir A Skeiky from Silver Spring, MD

Fusion Proteins Of Mycobacterium Tuberculosis Antigens And Their Uses
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US Patent:

6544522, Apr 8, 2003
Filed:

Dec 30, 1998
Appl. No.:

09/223040
Inventors:

Yasir Skeiky - Seattle WA
Mark Alderson - Bainbridge Island WA
Antonio Campos-Neto - Bainbridge Island WA
Assignee:

Corixa Corporation - Seattle WA
International Classification:

A61K 3902
US Classification:

4241901, 424 92, 4241301, 4241641, 4241681, 4242481, 435 691, 435 693, 514 44, 530350, 536 231, 536 237
Abstract:

The present invention relates to fusion proteins of antigens. In particular, it relates to two fusion proteins, each of which contains three individual antigens, and a fusion protein of two antigens, their coding sequences, and methods for their use in the treatment and prevention of tuberculosis.

Leishmania Antigens For Use In The Therapy And Diagnosis Of Leishmaniasis
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US Patent:

6607731, Aug 19, 2003
Filed:

May 5, 2000
Appl. No.:

09/565501
Inventors:

Steven G. Reed - Bellevue WA
Antonio Campos-Neto - Bainbridge Island WA
John R. Webb - Manotick, CA
Davin C. Dillon - Issaquah WA
Yasir A. Skeiky - Bellevue WA
Ajay Bhatia - Seattle WA
Rhea Coler - Seattle WA
Peter Probst - Seattle WA
Assignee:

Corixa Corporation - Seattle WA
International Classification:

A61K 39008
US Classification:

4242691, 4242651, 4241841, 4241911, 4241921, 4241851, 530300, 530350, 514 12, 514 46, 514 2, 536 231, 536 234
Abstract:

Compositions and methods for preventing, treating and detecting leishmaniasis and stimulating immune responses in patients are disclosed. The compounds provided include polypeptides that contain at least an immunogenic portion of one or more Leishmania antigens, or a variant thereof. Vaccines and pharmaceutical compositions comprising such polypeptides, or polynucleotides encoding such polypeptides, are also provided and may be used, for example, for the prevention and therapy of leishmaniasis, as well as for the detection of Leishmania infection.

Fusion Proteins Of Mycobacterium Tuberculosis Antigens And Their Uses
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US Patent:

6627198, Sep 30, 2003
Filed:

Apr 7, 1999
Appl. No.:

09/287849
Inventors:

Steven G. Reed - Bellevue WA
Yasir A. Skeiky - Seattle WA
Davin C. Dillon - Redmond WA
Mark Alderson - Bainbridge Island WA
Antonio Campos-Neto - Bainbridge Island WA
Assignee:

Corixa Corporation - Seattle WA
International Classification:

A61K 3902
US Classification:

4241901, 424 92, 4241301, 4241641, 4241681, 4242481, 435 691, 435 693, 514 44, 530350, 536 231, 536 237
Abstract:

The present invention relates to fusion proteins containing at least two antigens. In particular, it relates to bi-fusion proteins which contain two individual antigens, tri-fusion proteins which contain three antigens, tetra-fusion proteins which contain four antigens, and penta-fusion proteins which contain five antigens, and methods for their use in the diagnosis, treatment and prevention of tuberculosis infection.

Fusion Proteins Of Mycobacterium Tuberculosis Antigens And Their Uses
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US Patent:

6977069, Dec 20, 2005
Filed:

Feb 5, 2003
Appl. No.:

10/359460
Inventors:

Steven G. Reed - Bellevue WA, US
Yasir A. Skeiky - Bellevue WA, US
Davin C. Dillon - Redmond WA, US
Mark Alderson - Bainbridge WA, US
Antonio Campos-Neto - Bainbridge Island WA, US
Assignee:

Corixa Corporation - Seattle WA
International Classification:

A61K049/00
A61K039/04
A61K039/02
C07K001/00
US Classification:

424 92, 424 91, 4241301, 4241641, 4241681, 4241901, 4242481, 435 691, 435 693, 530300, 530350, 536 231, 536 237
Abstract:

The present invention relates to fusion proteins containing at least two antigens. In particular, it relates to bi-fusion proteins which contain two individual antigens, tri-fusion proteins which contain three antigens, tetra-fusion proteins which contain four antigens, and penta-fusion proteins which contain five antigens, and methods for their use in the diagnosis, treatment and prevention of tuberculosis infection.

Methods Of Using A Coding Sequence To Facilitate Stable And High Yield Expression Of The Heterologous Proteins
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US Patent:

7009042, Mar 7, 2006
Filed:

Oct 6, 2000
Appl. No.:

09/684215
Inventors:

Yasir Skeiky - Seattle WA, US
Jeffrey Guderian - Lynnwood WA, US
Assignee:

Corixa Corporation - Seattle WA
International Classification:

C07H 21/04
A61K 38/00
US Classification:

536 231, 435 691, 435455, 4353201, 514 2
Abstract:

The present invention relates generally to nucleic acid and amino acid sequences of a fusion polypeptide comprising a polypeptide, and a heterologous polypeptide of interest, expression vectors and host cells comprising such nucleic acids, and methods for producing such fusion polypeptides. In particular, the invention relates to materials and methods of using such sequence as a fusion partner to facilitate the stable and high yield expression of recombinant heterologous polypeptides of both eukaryotic and prokaryotic origin.

Fusion Proteins Of
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US Patent:

7026465, Apr 11, 2006
Filed:

Feb 18, 2003
Appl. No.:

10/369983
Inventors:

Yasir Skeiky - Bellevue WA, US
Jeff Guderian - Lynwood WA, US
Steven Reed - Bellevue WA, US
Assignee:

Corixa Corporation - Seattle WA
International Classification:

C07H 21/04
C07H 21/02
A61K 39/04
US Classification:

536 234, 424 91, 424 92, 424184, 4241921, 4242481, 536 231, 536 237
Abstract:

The present invention relates to compositions and fusion proteins containing at least two sp. antigens, and nucleic acids encoding such compositions and fusion proteins. The compositions of the invention increase serological sensitivity of sera from individuals infected with tuberculosis, and methods for their use in the diagnosis, treatment, and prevention of tuberculosis infection.

Fusion Proteins Of Mycobacterium Tuberculosis Antigens And Their Uses
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US Patent:

7064195, Jun 20, 2006
Filed:

Feb 5, 2003
Appl. No.:

10/359459
Inventors:

Yasir Skeiky - Bellevue WA, US
Mark Alderson - Bainbridge Island WA, US
Antonio Campos-Neto - Bainbridge Island WA, US
Assignee:

Corixa - Seattle WA
International Classification:

C07H 21/04
C07H 21/02
A61K 39/04
US Classification:

536 237, 424 92, 4241301, 4241641, 4241681, 4241901, 4242481, 435 691, 435 693, 514 44, 530350, 536 231
Abstract:

The present invention relates to fusion proteins of antigens. In particular, it relates to two fusion proteins, each of which contains three individual antigens, and a fusion protein of two antigens, their coding sequences, and methods for their use in the treatment and prevention of tuberculosis.

Fusion Proteins Of
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US Patent:

7083796, Aug 1, 2006
Filed:

Jun 20, 2001
Appl. No.:

09/886349
Inventors:

Yasir Skeiky - Seattle WA, US
Steven Reed - Bellevue WA, US
Mark Alderson - Bainbridge Island WA, US
Assignee:

Corixa Corporation - Seattle WA
International Classification:

A61K 39/04
A61K 49/00
A61K 45/00
US Classification:

4242481, 424 91, 424 92, 4241841, 4241851, 4241901, 4241921, 4242341, 4242781, 530300, 530350
Abstract:

The present invention relates to compositions and fusion proteins containing at least two sp. antigens, and nucleic acids encoding such compositions and fusion proteins. The compositions of the invention increase serological sensitivity of sera from individuals infected with tuberculosis, and methods for their use in the diagnosis, treatment, and prevention of tuberculosis infection.

Yasir A Skeiky