Yi I Li

US Patent:

6338951, Jan 15, 2002

Filed:

Jan 25, 1999

Appl. No.:

09/236468

Inventors:

Daniel Soppet - Centreville VA
Yi Li - Gaithersburg MD
Craig A. Rosen - Laytonsville MD
Steven M. Ruben - Olney MD

Assignee:

Human Genome Sciences, Inc. - Rockville MD

International Classification:

C07K 1472

US Classification:

435 691, 435 697, 530350, 530324, 530395, 530402, 514 12

Abstract:

Human G-protein parathyroid hormone (PTH) receptor polypeptides and DNA (RNA) encoding such polypeptides and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed are methods for utilizing such polypeptides for identifying antagonists and agonists to such polypeptides and methods of using the agonists and antagonists therapeutically to treat conditions related to the underexpression and overexpression of the PTH receptor receptor polypeptides. Also disclosed are diagnostic methods for detecting a mutation in the PTH receptor receptor nucleic acid sequences and detecting a level of the soluble form of the receptors in a sample derived from a host.

US Patent:

6372891, Apr 16, 2002

Filed:

Jun 24, 1999

Appl. No.:

09/339115

Inventors:

Daniel R. Soppet - Centreville VA
Yi Li - Gaithersburg MD
Craig A. Rosen - Laytonsville MD
Steven M. Ruben - Olney MD

Assignee:

Human Genome Sciences, Inc. - Rockville MD

International Classification:

C07K 1628

US Classification:

5303879, 5303881, 53038822, 5303871, 5303873, 5303891, 530350

Abstract:

Human G-protein coupled receptor polypeptides and DNA (RNA) encoding such polypeptides and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed were methods for utilizing such polypeptides for identifying antagonists and agonists to such polypeptides and methods of using the agonists and antagonists therapeutically to treat conditions related to the underexpression and overexpression of the G-protein coupled receptor polypeptides. Also disclosed are diagnostic methods for detecting a mutation, in the G-protein coupled receptor nucleic acid sequences and an altered level of the soluble form of the receptors.

US Patent:

6395514, May 28, 2002

Filed:

Nov 18, 1998

Appl. No.:

09/195106

Inventors:

Ying-Fei Wei - San Mateo CA
Yi Li - Sunnyvale CA
Jian Ni - Rockville MD
Craig A. Rosen - Laytonsville MD
Steven M. Ruben - Olney MD

Assignee:

Human Genome Sciences, Inc. - Rockville MD

International Classification:

C12N 510

US Classification:

435 695, 435 711, 435 712, 435471, 4353201, 435325, 4352523, 43525411, 536 231, 536 235, 530351, 424 851

Abstract:

The present invention relates to a novel CK-5 protein which is a member of the alpha chemokine family. In particular, isolated nucleic acid molecules are provided encoding the human CK-5 protein. CK-5 polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of CK-5 activity. Also provided are diagnostic methods for detecting immune system-related disorders and therapeutic methods for treating immune system-related disorders.

US Patent:

6410701, Jun 25, 2002

Filed:

Jun 5, 1995

Appl. No.:

08/462509

Inventors:

Daniel R. Soppet - Centreville VA
Yi Li - Gaithersburg MD
Craig A. Rosen - Laytonsville MD

Assignee:

Human Genome Sciences, Inc. - Rockville MD

International Classification:

C07H 2102

US Classification:

536 231, 536 234, 536 235, 536 243, 536 245, 435 41, 435 691, 435 697, 435 701

Abstract:

Human neuropeptide receptor polypeptides and DNA (RNA) encoding such polypeptides and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed are methods for utilizing such polypeptides for identifying antagonists and agonists to such polypeptides and methods of using the agonists and antagonists therapeutically to treat conditions related to the underexpression and overexpression of the neuropeptide receptor polypeptides, respectively. Also disclosed are diagnostic methods for detecting a mutation in the neuropeptide receptor nucleic acid sequences and an altered level of the soluble form of the receptors.

US Patent:

6420526, Jul 16, 2002

Filed:

Sep 8, 1998

Appl. No.:

09/149476

Inventors:

Steven M. Ruben - Olney MD
Craig A. Rosen - Laytonsville MD
Carrie L. Fischer - Burke VA
Daniel P. Soppet - Centreville VA
Kenneth C. Carter - North Potomac MD
Daniel R. Bednarik - Columbia MD
Gregory A. Endress - Potomac MD
Guo-Liang Yu - Berkeley CA
Jian Ni - Rockville MD
Ping Feng - Gaithersburg MD
Paul E. Young - Gaithersburg MD
John M. Greene - Gaithersburg MD
Ann M. Ferrie - Tewksbury MA
Roxanne Duan - Bethesda MD
Jing-Shan Hu - Sunnyvale CA
Kimberly A. Florence - Rockville MD
Henrik S. Olsen - Gaithersburg MD
Reinhard Ebner - Gaithersburg MD
Laurie A. Brewer - St. Paul MN
Paul A. Moore - Germantown MD
Yanggu Shi - Gaithersburg MD
David W. Lafleur - Washington DC
Yi Li - Sunnyvale CA
Zhizhen Zeng - Lansdale PA
Hla Kyaw - Frederick MD

Assignee:

Human Genome Sciences, Inc. - Rockville MD

International Classification:

C12Q 168

US Classification:

530350, 435 6, 536 231

Abstract:

The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating disorders related to these novel human secreted proteins.

US Patent:

6511826, Jan 28, 2003

Filed:

Feb 11, 2000

Appl. No.:

09/502783

Inventors:

Yi Li - Gaithersburg MD
Steven M. Ruben - Olney MD

Assignee:

Human Genome Sciences, Inc. - Rockville MD

International Classification:

C12P 2106

US Classification:

435 691, 4353201, 4352523, 536 231

Abstract:

Human G-protein chemokine receptor polypeptides and DNA (RNA) encoding such polypeptides and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed are methods for utilizing such polypeptides for identifying antagonists and agonists to such polypeptides and methods of using the agonists and antagonists therapeutically to treat conditions related to the underexpression and overexpression of the G-protein chemokine receptor polypeptides, respectively. Also disclosed are diagnostic methods for detecting a mutation in the G-protein chemokine receptor nucleic acid sequences and detecting a level of the soluble form of the receptors in a sample derived from a host.

US Patent:

6518404, Feb 11, 2003

Filed:

Mar 7, 2000

Appl. No.:

09/520210

Inventors:

Yi Li - Sunnyvale CA
Craig A. Rosen - Laytonsville MD
Chandrika Kumar - West Windsor NJ

Assignee:

Human Genome Sciences, Inc. - Rockville MD
Smithkline Beecham Corp. - Philadelphia PA

International Classification:

C07K 1628

US Classification:

5303879, 5303881, 5303871, 5303873, 53038815, 5303891

Abstract:

A human endothelin-bombesin receptor polypeptide and DNA (RNA) encoding such polypeptide and a procedure for disclosed. Also disclosed are methods for utilizing such polypeptide for identifying agonists and antagonists to such polypeptide. Agonists to the endothelin-bombesin receptor polypeptide of the present invention may be used to treat asthma, Parkinsons Disease, acute heart failure, hypotension and osteoporosis. Antagonists against such polypeptides may be used therapeutically to treat hypertension, ulcerigenesis, subarachnoid hemorrhage, asthma, tumors, ciclosporin toxicity, cancer and septic shock. Also disclosed are diagnostic methods for detecting mutations in the polynucleotides of the present invention and for detecting levels of the soluble polypeptides in samples derived from a host.

US Patent:

6525174, Feb 25, 2003

Filed:

Dec 4, 1998

Appl. No.:

09/205258

Inventors:

Paul Young - Gaithersburg MD
John M. Greene - Gaithersburg MD
Ann M. Ferrie - Tewksbury MA
Steven M. Ruben - Olney MD
Craig A. Rosen - Laytonsville MD
Jing-Shan Hu - Sunnyvale CA
Henrik S. Olsen - Gaithersburg MD
Reinhard Ebner - Gaithersburg MD
Laurie A. Brewer - St. Paul MN
Paul A. Moore - Germantown MD
Yanggu Shi - Gaithersburg MD
Charles Florence - Rockville MD
Kimberly Florence - Rockville MD
David W. Lafleur - Washington DC
Jian Ni - Rockville MD
Ping Fan - Gaithersburg MD
Ying-Fei Wei - Berkeley CA
Carrie L. Fischer - Burke VA
Daniel R. Soppet - Centreville VA
Yi Li - Sunnyvale CA
Zhizhen Zeng - Gaithersburg MD
Hla Kyaw - Frederick MD
Guo-Liang Yu - Berkeley CA
Ping Feng - Gaithersburg MD
Patrick J. Dillon - Carlsbad CA
Gregory A. Endress - Potomac MD
Kenneth C. Carter - North Potomac MD

Assignee:

Human Genome Sciences, Inc. - Rockville MD

International Classification:

C07K 1447

US Classification:

530350, 435 691, 514 2

Abstract:

The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating disorders related to these novel human secreted proteins.