Dr. Zheng graduated from the Tongji Med Univ, Wuhan City, Hubei, China in 1995. She works in Vacaville, CA and specializes in Gastroenterology. Dr. Zheng is affiliated with Kaiser Permanente Medical Center Vacaville.
David A. Williams - Cincinnati OH, US Yi Zheng - Cincinnati OH, US
Assignee:
Children's Hospital Medical Center - Cincinnati OH
International Classification:
A61K 38/00
US Classification:
514 12
Abstract:
Improved methods and pharmaceutical compositions are provided herein for mobilizing hematopoietic progenitor cells from bone marrow into peripheral blood, comprising the administration of an effective amount of an inhibitor of GTPases, such as Rac1 and Rac2 alone or in combination. Specifically, methods are disclosed for mobilizing hematopoietic stem cells into a subject's peripheral blood. In particular, embodiments of the method involve inhibition of both Rac1 and Rac2 GTPases to increase the numbers of hematopoietic stem cells into a subject's peripheral blood of a subject. The subject's blood can be processed and used to repopulate the destroyed lymphohematopoietic system of a recipient and may in the future be utilized to repair a variety of non-hematopoietic tissues. Therefore, hematopoietic stem cells mobilized into a subject's peripheral blood by the method of the invention is useful as a source of donor cells in bone marrow transplantation for the treatment of a variety of disorders, including cancer, anemia, autoimmunity and immunodeficiency. They can also be used for increasing white blood cell survival and for chemotherapy.
Yi Zheng - Cincinnati OH, US Jie Zheng - Memphis TN, US Yuan Gao - Port Jefferson NY, US John B. Dickerson - Memphis TN, US
Assignee:
Children's Hospital Medical Center - Cincinnati OH St. Jude Children's Research Hospital - Memphis TN Girindus America, Inc. - Cincinnati OH
International Classification:
A61K 31/506
US Classification:
514275
Abstract:
The preferred embodiments generally relate to methods and compositions that affect the GTP-binding activity of members of the Rho family GTPases, preferably Rac (Rac1, Rac2 and/or Rac3), such compositions include compounds that modulate the GTP/GDP exchange activity, along with uses for the compounds including screening for compounds which recognize Rac GTPase, and methods of treating pathological conditions associated or related to a Rho family GTPase, including Rac. The preferred embodiments also relate to methods of using such compounds, or derivatives thereof, e. g. , in therapeutics, diagnostics, and as research tools.
Gtpase Inhibitors And Use Thereof For Controlling Platelet Hyperactivity
Yi Zheng - Cincinnati OH, US Huzoor Akbar - Athens OH, US David A. Williams - Cincinnati OH, US Wieslaw Adam Mazur - Mason OH, US
Assignee:
Cincinnati Children's Hospital Medical Center - Cincinnati OH
International Classification:
A61K 31/506
US Classification:
514275
Abstract:
The preferred embodiments generally relate to methods and compositions that affect the GTP-binding activity of members of the Rho family GTPases, preferably Rac (Rac1, Rac2 and/or Rac3), such compositions include compounds that modulate the GTP/GDP exchange activity, along with uses for the compounds including screening for compounds which recognize Rac GTPase, and methods of treating pathological conditions associated or related to a Rho family GTPase, including Rac. The preferred embodiments also relate to methods of using such compounds, or derivatives thereof, e. g. , in therapeutics, diagnostics, and as research tools.
Method Of Identifying Inhibitors Using A 3-D Structure Of Rac-1 Gtpase
Yi Zheng - Cincinnati OH, US Nicolas Nassar - Coram NY, US Karlheinz R. Skowronek - Huntington Station NY, US
Assignee:
Children's Hospital Medical Center - Cincinnati OH The Research Foundation of State University of New York - Stony Brook NY
International Classification:
G01N 31/00 G06G 7/58
US Classification:
702 27, 703 11
Abstract:
The preferred embodiments generally relate to methods and compositions that affect the GTP-binding activity of members of the Rho family GTPases, preferably Rac (Rac1, Rac2 and/or Rac3), such compositions include compounds that modulate the GTP/GDP exchange activity, along with uses for the compounds including screening for compounds which recognize Rac GTPase, and methods of treating pathological conditions associated or related to a Rho family GTPase, including Rac. The preferred embodiments also relate to methods of using such compounds, or derivatives thereof, e. g. , in therapeutics, diagnostics, and as research tools.
Yi Zheng - Cincinnati OH, US David A. Williams - Cincinnati OH, US
Assignee:
Children's Hospital Medical Center - Cincinnati OH
International Classification:
C07K 14/00 A01N 37/18
US Classification:
530350, 514 2
Abstract:
Chimeric peptides or fusion proteins are disclosed that include a RhoGAP activity domain and at least one specificity domain that targets a specific Rho protein. The fusion proteins can be used to inhibit any GTPase activity within a cell. The fusion proteins are particularly advantageous for the treatment of cancer. The present invention generally relates to chimeric peptides capable of regulating GTPases, and more particularly, to methods of targeting individual GTPases by using GTPase-activating proteins. Such proteins may be used for the treatment of cancers and other GTPase-related diseases. This invention relates to nucleic acid molecules and the encoded GTPase activating proteins, and variants thereof, and to the use of these molecules in the characterization, diagnosis, prevention, and treatment of cell signaling, immune, and cell proliferative disorders, particularly cancer. Disclosed herein are compounds and methods for regulating transcription of a selected gene.
Yi Zheng - Cincinnati OH, US David A. Williams - Cincinnati OH, US
Assignee:
Children's Hospital Medical Center - Cincinnati OH
International Classification:
C07K 14/00 A61K 38/00
US Classification:
530350, 514 11
Abstract:
Chimeric peptides or fusion proteins are disclosed that include a RhoGAP activity domain and at least one specificity domain that targets a specific Rho protein. The fusion proteins can be used to inhibit any GTPase activity within a cell. The fusion proteins are particularly advantageous for the treatment of cancer. The present invention generally relates to chimeric peptides capable of regulating GTPases, and more particularly, to methods of targeting individual GTPases by using GTPase-activating proteins. Such proteins may be used for the treatment of cancers and other GTPase-related diseases. This invention relates to nucleic acid molecules and the encoded GTPase activating proteins, and variants thereof, and to the use of these molecules in the characterization, diagnosis, prevention, and treatment of cell signaling, immune, and cell proliferative disorders, particularly cancer. Disclosed herein are compounds and methods for regulating transcription of a selected gene.
Children's Hospital Medical Center - Cincinnati OH
International Classification:
A61K 39/00 A01N 25/00
US Classification:
4241841, 514885
Abstract:
Methods, processes, uses, and pharmaceutical compositions are provided herein for mobilizing hematopoietic progenitor cells and/or cancer stem cells from bone marrow into peripheral blood, comprising the administration of an effective amount of an inhibitor of GTPases, such as a Cdc-42 specific inhibitor alone or in combination with one or more additional agents. Specifically, methods are disclosed for mobilizing hematopoietic stem cells into a subject's peripheral blood. In particular, embodiments of the method involve specific inhibition of the Cdc42 GTPase to increase the numbers of hematopoietic stem cells into a subject's peripheral blood of a subject.
Yi Zheng - Cincinnati OH, US David Williams - Cincinnati OH, US
International Classification:
A61K039/395 C07K016/44
US Classification:
424178100, 530387300
Abstract:
Chimeric peptides or fusion proteins are disclosed that include a RhoGAP activity domain and at least one specificity domain that targets a specific Rho protein. The fusion proteins can be used to inhibit any GTPase activity within a cell. The fusion proteins are particularly advantageous for the treatment of cancer. The present invention generally relates to The present invention generally relates to chimeric peptides capable of regulating GTPases, and more particularly, to methods of targeting individual GTPases by using GTPase-activating proteins. Such proteins may be used for the treatment of cancers and other GTPase-related diseases. This invention relates to nucleic acid molecules and the encoded GTPase activating proteins, and variants thereof, and to the use of these molecules in the characterization, diagnosis, prevention, and treatment of cell signaling, immune, and cell proliferative disorders, particularly cancer. Disclosed herein are compounds and methods for regulating transcription of a selected gene. Methods are provided for constructing and for using such compounds to regulate transcription of a selected gene.
Director at PMC Connect I am born and raised in China. After my study I work in China for an UK investment bank (Chief representative officer) and Unilever-China (National Planning... I am born and raised in China. After my study I work in China for an UK investment bank (Chief representative officer) and Unilever-China (National Planning Manager). I live sinds 1997 in Holland and have worked for multinationals such as Sara Lee|DE and SC Johnson (senior buyer). In 2004 I started...
Meyer London Public School 2 New York NY 1993-1997, Corlears Junior High School 56 New York NY 1997-2001, Murry Bergtraum High School New York NY 2001-2004
Dane McSpedon (1986-1990), Kristin Parsons (1993-1997), Jeffrey Hartford (1975-1979), Yi Dong Zheng (2004-2008), Mary Ann Hughes (1970-1974)
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Yi Zheng
Work:
American Red Cross - Team Mentor Cincinnati Office of U.S. Senator Brown - Staff Intern (2012-2012) China Mobile - Customer Services and Sales Summer Intern (2010-2010)
Education:
University of Cincinnati - Statistics, Tianjin University of Commerce China - Finance
About:
Objective Obtain an entry-level analyst opportunity that utilizes statistical and problem solving skills
Yi Zheng (Ivy)
Yi Zheng
About:
有点鬼主意,有点热情...
Yi Zheng
Work:
Ucsf
Yi Zheng
About:
A lazybones.
Yi Zheng
About:
业余摄影使用的装备列... 5D MARK IIEF 85/1.2L USMEF 180mm f/3.5 L MACROEF 16-35/2.8L IIEF 70-200mm f/2.8 II L ISEF 1.4x III ExtenderEF 2x II Extender CANON 430EX、580EX