Yiguang Wang

US Patent:

20140023590, Jan 23, 2014

Filed:

Aug 11, 2011

Appl. No.:

13/825518

Inventors:

Jinming Gao - Plano TX, US
David Boothman - Dallas TX, US
Kejin Zhou - Dallas TX, US
Xiaonan Huang - Beijing, CN
Yiguang Wang - Dallas TX, US

Assignee:

The Board of Regents of the University of Texas System - Austin TX

International Classification:

A61K 49/00
A61K 31/704
A61K 31/337
A61K 9/50

US Classification:

424 96, 525421, 424497, 514 34, 514449, 424 91

Abstract:

Provided herein are block copolymers comprising a hydrophilic polymer segment and a hydrophobic polymer segment, wherein the hydrophilic polymer segment comprises a polymer selected from the group consisting of: poly(ethylene oxide) (PEO), poly(methacrylate phosphatidyl choline) (MPC), and polyvinylpyrrolidone (PVP), wherein the hydrophobic polymer segment comprises wherein R′ is —H or —CH, wherein R is —NRR, wherein Rand Rare alkyl groups, wherein Rand Rare the same or different, wherein Rand Rtogether have from 5 to 16 carbons, wherein Rand Rmay optionally join to form a ring, wherein n is 1 to about 10, and wherein x is about 20 to about 200 in total. Also provided are pH-sensitive micelle compositions for therapeutic and diagnostic applications.

US Patent:

20230085899, Mar 23, 2023

Filed:

Jul 1, 2022

Appl. No.:

17/810591

Inventors:

- Austin TX, US
David BOOTHMAN - , US
Kejin ZHOU - Dallas TX, US
Xiaonan HUANG - Beijing, CN
Yiguang WANG - Dallas TX, US

Assignee:

The Board of Regents of The University of Texas System - Austin TX

International Classification:

C08F 293/00
C07D 311/92
A61K 47/58
A61K 47/62
A61K 9/127
A61K 49/00
A61K 31/352
A61P 35/00
C08F 299/02
A61K 47/69
C08G 81/02
G01N 33/58
A61K 9/50
A61K 31/337
A61K 31/704
A61K 9/107
A61K 47/68

Abstract:

Provided herein are block copolymers comprising a hydrophilic polymer segment and a hydrophobic polymer segment, wherein the hydrophilic polymer segment comprises a polymer selected from the group consisting of: poly(ethylene oxide) (PEO), poly(methacrylate phosphatidyl choline) (MPC), and polyvinylpyrrolidone (PVP), wherein the hydrophobic polymer segment compriseswherein R′ is —H or —CH, wherein R is —NRR, wherein Rand Rare alkyl groups, wherein Rand Rare the same or different, wherein Rand Rtogether have from 5 to 16 carbons, wherein Rand Rmay optionally join to form a ring, wherein n is 1 to about 10, and wherein x is about 20 to about 200 in total. Also provided are pH-sensitive micelle compositions for therapeutic and diagnostic applications.

US Patent:

20210338840, Nov 4, 2021

Filed:

Apr 15, 2021

Appl. No.:

17/231922

Inventors:

- Austin TX, US
Gang HUANG - Plano TX, US
Tian ZHAO - Irving TX, US
Xinpeng MA - Dallas TX, US
Yiguang WANG - Dallas TX, US
Yang LI - Dallas TX, US
Baran D. SUMER - Dallas TX, US

Assignee:

The Board of Regents of the University of Texas System - Austin TX

International Classification:

A61K 49/00
G01N 21/64
C08F 8/30
C08F 8/32
C08F 8/34
C08F 8/42
C09B 69/10
G01N 33/58
G01N 33/84

Abstract:

The present disclosure relates to polymers which contain a hydrophobic and hydrophilic segment which is sensitive to pH. In some aspects, the polymers form a micelle which is sensitive to pH and results in a change in fluorescence based upon the particular pH. In some aspects, the disclosure also provides methods of using the polymers for the imaging of cellular or extracellular environment or delivering a drug.

US Patent:

20200330383, Oct 22, 2020

Filed:

Mar 10, 2020

Appl. No.:

16/814845

Inventors:

- Austin TX, US
David BOOTHMAN - , US
Kejin ZHOU - Dallas TX, US
Xiaonan HUANG - Beijing, CN
Yiguang WANG - Dallas TX, US

Assignee:

The Board of Regents of the University of Texas System - Austin TX

International Classification:

A61K 9/107
C08G 81/02
A61K 31/704
A61K 31/337
A61K 49/00
A61K 47/69
A61K 47/62

Abstract:

Provided herein are block copolymers comprising a hydrophilic polymer segment and a hydrophobic polymer segment, wherein the hydrophilic polymer segment comprises a polymer selected from the group consisting of: poly(ethylene oxide) (PEO), poly(methacrylate phosphatidyl choline) (MPC), and polyvinylpyrrolidone (PVP), wherein the hydrophobic polymer segment compriseswherein R′ is —H or —CH, wherein R is —NRR, wherein Rand Rare alkyl groups, wherein Rand Rare the same or different, wherein Rand Rtogether have from 5 to 16 carbons, wherein Rand Rmay optionally join to form a ring, wherein n is 1 to about 10, and wherein x is about 20 to about 200 in total. Also provided are pH-sensitive micelle compositions for therapeutic and diagnostic applications.

US Patent:

20200333350, Oct 22, 2020

Filed:

Mar 10, 2020

Appl. No.:

16/814898

Inventors:

- Austin TX, US
David BOOTHMAN - , US
Kejin ZHOU - Dallas TX, US
Xiaonan HUANG - Beijing, CN
Yiguang WANG - Dallas TX, US

Assignee:

The Board of Regents of the University of Texas System - Austin TX

International Classification:

G01N 33/58

Abstract:

Provided herein are block copolymers comprising a hydrophilic polymer segment and a hydrophobic polymer segment, wherein the hydrophilic polymer segment comprises a polymer selected from the group consisting of: poly(ethylene oxide) (PEO), poly(methacrylate phosphatidyl choline) (MPC), and polyvinylpyrrolidone (PVP), wherein the hydrophobic polymer segment compriseswherein R′ is —H or —CH, wherein R is —NRR, wherein Rand Rare alkyl groups, wherein Rand Rare the same or different, wherein Rand Rtogether have from 5 to 16 carbons, wherein Rand Rmay optionally join to form a ring, wherein n is 1 to about 10, and wherein x is about 20 to about 200 in total. Also provided are pH-sensitive micelle compositions for therapeutic and diagnostic applications.

US Patent:

20200325265, Oct 15, 2020

Filed:

Mar 10, 2020

Appl. No.:

16/814803

Inventors:

- Austin TX, US
David BOOTHMAN - , US
Kejin ZHOU - Dallas TX, US
Xiaonan HUANG - Beijing, CN
Yiguang WANG - Dallas TX, US

Assignee:

The Board of Regents of the University of Texas System - Austin TX

International Classification:

C08F 299/02
A61K 9/107
A61P 35/00

Abstract:

Provided herein are block copolymers comprising a hydrophilic polymer segment and a hydrophobic polymer segment, wherein the hydrophilic polymer segment comprises a polymer selected from the group consisting of: poly(ethylene oxide) (PEO), poly(methacrylate phosphatidyl choline) (MPC), and polyvinylpyrrolidone (PVP), wherein the hydrophobic polymer segment compriseswherein R′ is —H or —CH, wherein R is —NRR, wherein Rand Rare alkyl groups, wherein Rand Rare the same or different, wherein Rand Rtogether have from 5 to 16 carbons, wherein Rand Rmay optionally join to form a ring, wherein n is 1 to about 10, and wherein x is about 20 to about 200 in total. Also provided are pH-sensitive micelle compositions for therapeutic and diagnostic applications.

US Patent:

20180369424, Dec 27, 2018

Filed:

Aug 27, 2018

Appl. No.:

16/114187

Inventors:

- Austin TX, US
Gang HUANG - Plano TX, US
Tian ZHAO - Irving TX, US
Xinpeng MA - Dallas TX, US
Yiguang WANG - Dallas TX, US
Yang LI - Dallas TX, US
Baran D. SUMER - Dallas TX, US

Assignee:

The Board of Regents of the University of Texas System - Austin TX

International Classification:

A61K 49/00
C09B 69/10
G01N 33/84
G01N 33/58
G01N 21/64
C08F 8/42
C08F 8/34
C08F 8/32
C08F 8/30

Abstract:

The present disclosure relates to polymers which contain a hydrophobic and hydrophilic segment which is sensitive to pH. In some aspects, the polymers form a micelle which is sensitive to pH and results in a change in fluorescence based upon the particular pH. In some aspects, the disclosure also provides methods of using the polymers for the imaging of cellular or extracellular environment or delivering a drug.

US Patent:

20180291134, Oct 11, 2018

Filed:

Jun 13, 2018

Appl. No.:

16/006885

Inventors:

- Austin TX, US
David BOOTHMAN - Dallas TX, US
Kejin ZHOU - Dallas TX, US
Xiaonan HUANG - Beijing, CN
Yiguang WANG - Dallas TX, US

Assignee:

The Board of Regents of the University of Texas System - Austin TX

International Classification:

C08F 293/00
A61K 31/704
A61K 47/62
A61K 47/68
C07D 311/92
A61K 49/00
A61K 47/58
A61K 31/352
A61K 31/337
A61K 9/50
A61K 9/127
A61K 9/107
C08F 220/34

Abstract:

Provided herein are block copolymers comprising a hydrophilic polymer segment and a hydrophobic polymer segment, wherein the hydrophilic polymer segment comprises a polymer selected from the group consisting of: poly(ethylene oxide) (PEO), poly(methacrylate phosphatidyl choline) (MPC), and polyvinylpyrrolidone (PVP), wherein the hydrophobic polymer segment compriseswherein R′ is —H or —CH, wherein R is —NRR, wherein Rand Rare alkyl groups, wherein Rand Rare the same or different, wherein Rand Rtogether have from 5 to 16 carbons, wherein Rand Rmay optionally join to form a ring, wherein n is 1 to about 10, and wherein x is about 20 to about 200 in total. Also provided are pH-sensitive micelle compositions for therapeutic and diagnostic applications.