Ying Ji Buechler from 1343 Cassins St, Carlsbad, CA 92008, age 62, Phone: 7608049133

Resumes

Vice President, Development

view source

Location:

San Diego, CA

Industry:

Biotechnology

Work:

Ambrx since Dec 2003
Director, Product Development and Characterization

Education:

University of California, San Diego 1986 - 1992
Ph.D., Biochemistry

Skills:

Protein Chemistry
Protein Purification
Biotechnology
Purification
Biochemistry
Analytical Chemistry
Technology Transfer
Molecular Biology
Formulation
R&D
Recombinant Dna Technology
Clinical Development
Process Simulation
Science

Us Patents

Methods For Expression And Purification Of Pegylated Recombinant Human Growth Hormone Containing A Non-Naturally Encoded Keto Amino Acid
view source
US Patent:

7947473, May 24, 2011
Filed:

Jan 31, 2008
Appl. No.:

11/874100
Inventors:

Ying Buechler - Carlsbad CA, US
Ricky Lieu - San Diego CA, US
Michael Ong - San Diego CA, US
Stuart Bussell - Carlsbad CA, US
Nick Knudsen - San Diego CA, US
Ho Sung Cho - San Diego CA, US
Assignee:

AMBRX, Inc. - La Jolla CA
International Classification:

C12N 15/09
A61K 38/27
C07K 14/00
US Classification:

435 694, 424123, 424124, 514 114, 530399, 530416
Abstract:

The present invention relates generally to the production, purification, and isolation of human growth hormone (hGH). More particularly, the invention relates to the production, purification, and isolation of substantially purified hGH comprising non-naturally encoded amino acids and hGH from recombinant host cells or culture medium including, for example, yeast, insect, mammalian and bacterial host cells. The process of the present invention is also useful for purification of hGH linked to polymers or other molecules.

Methods For Expression And Purification Of Recombinant Human Growth Hormone Mutants
view source
US Patent:

7959926, Jun 14, 2011
Filed:

Oct 17, 2007
Appl. No.:

11/874068
Inventors:

Ying Buechler - Carlsbad CA, US
Ricky Lieu - San Diego CA, US
Michael Ong - San Diego CA, US
Stuart Bussell - Carlsbad CA, US
Nick Knudsen - San Diego CA, US
Ho Sung Cho - San Diego CA, US
Assignee:

Ambrx, Inc. - La Jolla CA
International Classification:

A61K 39/00
A61K 38/02
A61K 38/27
C12P 21/00
C07K 1/16
C07H 21/00
US Classification:

4242001, 4241981, 424124, 536 2351, 514 114, 435 76, 435 691, 530417
Abstract:

The present invention relates generally to the production, purification, and isolation of human growth hormone (hGH). More particularly, the invention relates to the production, purification, and isolation of substantially purified hGH comprising non-naturally encoded amino acids and hGH from recombinant host cells or culture medium including, for example, yeast, insect, mammalian and bacterial host cells. The process of the present invention is also useful for purification of hGH linked to polymers or other molecules.

Process Of Producing Non-Naturally Encoded Amino Acid Containing High Conjugated To A Water Soluble Polymer
view source
US Patent:

8080391, Dec 20, 2011
Filed:

Dec 21, 2005
Appl. No.:

11/315752
Inventors:

Ying Buechler - Carlsbad CA, US
Ricky Lieu - San Diego CA, US
Michael Ong - San Diego CA, US
Stuart Bussell - Carlsbad CA, US
Nick Knudsen - San Diego CA, US
Ho Sung Cho - San Diego CA, US
Assignee:

AMBRX, Inc. - La Jolla CA
International Classification:

C12N 15/09
A61K 38/27
C07K 14/00
US Classification:

435 694, 435123, 514 114, 530399, 530416
Abstract:

The present invention relates generally to the production, purification, and isolation of human growth hormone (hGH). More particularly, the invention relates to the production, purification, and isolation of substantially purified hGH from recombinant host cells or culture medium including, for example, yeast, insect, mammalian and bacterial host cells. The process of the present invention is also useful for purification of hGH linked to polymers or other molecules.

Formulations Of Human Growth Hormone Comprising A Non-Naturally Encoded Amino Acid
view source
US Patent:

8163695, Apr 24, 2012
Filed:

Oct 25, 2007
Appl. No.:

11/924154
Inventors:

Anna-Maria A. Hays - San Diego CA, US
Ying Buechler - Carlsbad CA, US
David C. Litzinger - Poway CA, US
Assignee:

Ambrx - La Jolla CA
International Classification:

A61K 38/27
C07K 14/61
C07K 1/107
US Classification:

514 114, 4241981, 530350, 530399, 530402
Abstract:

Formulations of modified human growth hormone polypeptides are provided.

Methods For Expression And Purification Of Recombinant Human Growth Hormone
view source
US Patent:

8178108, May 15, 2012
Filed:

Oct 17, 2007
Appl. No.:

11/874086
Inventors:

Ying Buechler - Carlsbad CA, US
Ricky Lieu - San Diego CA, US
Michael Ong - San Diego CA, US
Stuart Bussell - Carlsbad CA, US
Nick Knudsen - San Diego CA, US
Ho Sung Cho - San Diego CA, US
Assignee:

Ambrx, Inc. - La Jolla CA
International Classification:

A61K 38/27
A61K 38/18
A61K 39/00
C07K 1/14
C07K 1/16
C07K 1/18
C07H 21/04
US Classification:

4241981, 424123, 424124, 4242001, 514 32, 514 114, 530399, 530412, 530416, 530417, 435 694, 435 691, 536 2351
Abstract:

The present invention relates generally to the production, purification, and isolation of human growth hormone (hGH). More particularly, the invention relates to the production, purification, and isolation of substantially purified hGH comprising non-naturally encoded amino acids and hGH from recombinant host cells or culture medium including, for example, yeast, insect, mammalian and bacterial host cells. The process of the present invention is also useful for purification of hGH linked to polymers or other molecules.

Modified Human Growth Hormone Formulations With An Increased Serum Half-Life
view source
US Patent:

8178494, May 15, 2012
Filed:

Oct 25, 2007
Appl. No.:

11/924242
Inventors:

Anna-Maria Hays - La Jolla CA, US
Ying Buechler - Carlsbad CA, US
David C. Litzinger - Poway CA, US
Assignee:

AMBRX, Inc. - La Jolla CA
International Classification:

A61K 38/27
A61K 39/00
C07K 14/61
C07K 14/00
US Classification:

514 114, 530399, 530402, 4241981
Abstract:

Formulations of modified growth hormone polypeptides are provided, including human growth hormone polypeptides with one or more non-naturally encoded amino acids with an increased half-life.

Pegylated Interferon Alpha-1B
view source
US Patent:

20060029573, Feb 9, 2006
Filed:

Jun 30, 2005
Appl. No.:

11/172409
Inventors:

Chun Shen - San Diego CA, US
Ying Buechler - Carlsbad CA, US
Xiaochun Chen - Carlsbad CA, US
Dawn Wen - San Diego CA, US
Yixin Wang - Shenzhen, CN
Shehui He - Shenzhen, CN
Qianlan Wang - Shenzhen, CN
International Classification:

A61K 38/21
C07K 14/56
US Classification:

424085700, 530351000
Abstract:

The invention provides PEG-IFN α-1b conjugates, where a PEG moiety is covalently bound to Cysof human IFN α-1b conjugates. A pharmaceutical composition and a method for treating inflammatory diseases, infections, and cancer are also provided. The invention further relates to a method for the modification of interferons by conjugation of a PEG moiety to free cysteine residues in interferon molecules.

Formulations Of Human Growth Hormone Comprising A Non-Naturally Encoded Amino Acid
view source
US Patent:

20060135427, Jun 22, 2006
Filed:

Dec 21, 2005
Appl. No.:

11/316483
Inventors:

Anna-Maria Hays - La Jolla CA, US
Ying Buechler - Carlsbad CA, US
David Litzinger - Poway CA, US
Assignee:

Ambrx, Inc. - La Jolla CA
International Classification:

A61K 38/27
US Classification:

514012000
Abstract:

Formulations of modified human growth hormone polypeptides are provided.

Ying Ji Buechler

Ying Buechler Phones & Addresses

Work

Education

Skills

Industries

Resumes

Vice President, Development

Us Patents

Methods For Expression And Purification Of Pegylated Recombinant Human Growth Hormone Containing A Non-Naturally Encoded Keto Amino Acid

Methods For Expression And Purification Of Recombinant Human Growth Hormone Mutants

Process Of Producing Non-Naturally Encoded Amino Acid Containing High Conjugated To A Water Soluble Polymer

Formulations Of Human Growth Hormone Comprising A Non-Naturally Encoded Amino Acid

Methods For Expression And Purification Of Recombinant Human Growth Hormone

Modified Human Growth Hormone Formulations With An Increased Serum Half-Life

Pegylated Interferon Alpha-1B

Formulations Of Human Growth Hormone Comprising A Non-Naturally Encoded Amino Acid