Ying Chen

US Patent:

D522990, Jun 13, 2006

Filed:

Jan 18, 2005

Appl. No.:

29/221462

Inventors:

Forest Sun - Oak Hill VA, US
Ying Chen - Oak Hill VA, US

International Classification:

1403

US Classification:

D14138

US Patent:

20200360542, Nov 19, 2020

Filed:

Aug 4, 2020

Appl. No.:

16/984415

Inventors:

- Baltimore MD, US
Ronnie C. Mease - Fairfax VA, US
Sangeeta Ray - Ellicott City MD, US
Ying Chen - Lutherville-Timonium MD, US
Xing Yang - Balitmore MD, US

International Classification:

A61K 51/04
A61K 49/00
C07C 271/22
C07C 275/16
C07C 323/62
C07D 209/12
C07D 213/82
A61K 41/00

Abstract:

Carbamate and beta-amino acid urea-based scaffolds that have high binding affinity to PSMA are disclosed. These scaffolds can be radiolabeled and used for imaging cells and tumors that express PSMA or for cancer radiotherapy. These compounds also can comprise a fluorescent dye and be used for imaging cells and tumors that express PSMA or for photodynamic therapy.

US Patent:

20200282083, Sep 10, 2020

Filed:

Nov 5, 2019

Appl. No.:

16/674089

Inventors:

- Baltimore MD, US
Ronnie Charles Mease - Fairfax VA, US
Ying Chen - Lutherville-Timonium MD, US

International Classification:

A61K 51/04
C07F 7/22
A61K 9/127
C07C 275/16
C07D 213/61
C07D 213/74
C07D 213/82
C07C 275/18

Abstract:

Prostate-specific membrane antigen (PSMA) binding compounds having radioisotope substituents are described, as well as chemical precursors thereof. Compounds include pyridine containing compounds, compounds having phenylhydrazine structures, and acylated lysine compounds. The compounds allow ready incorporation of radionuclides for single photon emission computed tomography (SPECT) and positron emission tomography (PET) for imaging, for example, prostate cancer cells and angiogenesis.

US Patent:

20200283412, Sep 10, 2020

Filed:

Jun 15, 2018

Appl. No.:

16/623208

Inventors:

- Baltimore MD, US
Ronnie C. Mease - Fairfax VA, US
Ying Chen - Timonium MD, US
Sangeeta Ray - Ellicott City MD, US

International Classification:

C07D 403/06
A61K 49/00

Abstract:

Compositions and methods for visualizing tissue under illumination with near-infrared radiation, including compounds comprising near-infrared, closed chain, sulfo-cyanine dyes and prostate specific membrane antigen ligands are disclosed.

US Patent:

20200216402, Jul 9, 2020

Filed:

Mar 16, 2020

Appl. No.:

16/820052

Inventors:

- Baltimore MD, US
Ronnie C. Mease - Fairfax VA, US
Ying Chen - Timonium MD, US
Sangeeta Ray - Ellicott City MD, US

International Classification:

C07D 257/02
A61K 51/04
C07D 209/24
C07F 5/02
A61K 49/00
C07D 209/12
C07D 209/14
C07D 249/04
C07D 311/14
C07D 255/02
C07D 311/20
C07D 213/04
C07D 311/82
G01N 33/50
C07F 13/00

Abstract:

Compositions and methods for visualizing tissue under illumination with near-infrared radiation, including compounds comprising near-infrared, closed chain, sulfo-cyanine dyes and prostate specific membrane antigen ligands are disclosed.

US Patent:

20190175054, Jun 13, 2019

Filed:

Aug 24, 2018

Appl. No.:

16/112609

Inventors:

- College Park MD, US
- Urbana IL, US
Hugh A. Bruck - Wheaton MD, US
Ying Chen - College Park MD, US
Thenkurussi Kesavadas - Mahomet IL, US

Assignee:

University of Maryland - College Park MD
The Board of Trustees of the University of Illinois - Urbana IL

International Classification:

A61B 5/053
A61B 5/00

Abstract:

A pressure sensing system includes at least two pressure sensing layers. The first pressure sensing layer includes a first sensing system configured in a layer, a first layer of foam having a Young's modulus and mounted between a first sensing system configured in a layer, and a second sensing system configured in a layer; at least a second pressure sensing layer including the second sensing system configured in a layer, and a second layer of foam having a Young's modulus that is greater than the Young's modulus of the first layer of foam and mounted between the second sensing system configured in a layer and a rigid substrate having a Young's modulus greater than the layer of the first sensing system, the first layer of foam, the layer of the second sensing system, and the second layer of foam. The pressure sensing system thereby defines a multi-layer pressure sensing system.

US Patent:

20190177275, Jun 13, 2019

Filed:

Jun 9, 2017

Appl. No.:

16/308128

Inventors:

- Baltimore MD, US
Daniel P. Holt - Severna Park MD, US
Ying Chen - Lutherville-Timonium MD, US
Ronnie C. Mease - Fairfax VA, US
Hong Fan - Timonium MD, US
Martin G. Pomper - Baltimore MD, US
Robert F. Dannals - Sparks MD, US

International Classification:

C07D 213/42
A61P 35/00
A61K 51/04
C07B 59/00

Abstract:

Methods, and related compositions, for the improved synthesis of [F]DCFPyL are disclosed. Also provided are methods, and related compositions, for the use of [F]DCFPyL so produced.

US Patent:

20180236110, Aug 23, 2018

Filed:

Jan 8, 2018

Appl. No.:

15/864236

Inventors:

- Baltimore MD, US
RONNIE CHARLES MEASE - FAIRFAX VA, US
YING CHEN - LUTHERVILLE-TIMONIUM MD, US

International Classification:

A61K 51/04
C07D 213/82
A61K 9/127
C07C 275/16
C07D 213/74
C07F 7/22
C07C 275/18
C07D 213/61

Abstract:

Prostate-specific membrane antigen (PSMA) binding compounds having radioisotope substituents are described, as well as chemical precursors thereof. Compounds include pyridine containing compounds, compounds having phenylhydrazine structures, and acylated lysine compounds. The compounds allow ready incorporation of radionuclides for single photon emission computed tomography (SPECT) and positron emission tomography (PET) for imaging, for example, prostate cancer cells and angiogenesis.