Ying Quan Chen

US Patent:

7935787, May 3, 2011

Filed:

Apr 19, 2007

Appl. No.:

11/737674

Inventors:

Lakshmi Khandke - Nanuet NY, US
Ronald Malone - Madison NJ, US
Xudong Yang - Tappan NY, US
Hanyoung Han - Fort Lee NJ, US
Jee Loon Look - Gaithersburg MD, US
Zhaowei Jin - Cary NC, US
Ying Chen - Apex NC, US

Assignee:

Wyeth LLC - Madison NJ

International Classification:

A61K 31/715
C07K 14/00

US Classification:

530350, 514 54

Abstract:

The present invention addresses an ongoing need in the art to improve the stability of immunogenic compositions such as polysaccharide-protein conjugates and protein immunogens. The invention broadly relates to novel formulations which stabilize and inhibit precipitation of immunogenic compositions. More particularly, the invention described hereinafter, addresses a need in the art for formulations which stabilize and inhibit particulate formation (e. g. , aggregation, precipitation) of immunogenic compositions which are processed, developed, formulated, manufactured and/or stored in container means such as fermentors, bioreactors, vials, flasks, bags, syringes, rubber stoppers, tubing and the like.

US Patent:

8521632, Aug 27, 2013

Filed:

Jul 24, 2009

Appl. No.:

12/508987

Inventors:

Russell E. Planitzer - New York NY, US
Mark Asdoorian - Lynn MA, US
David Brown - Sudbury MA, US
Ying Chen - Fitchburg MA, US
Leonard Driscoll - Andover MA, US
Jeffrey B. Levering - Harvard MA, US
Alex Magary - Andover MA, US

Assignee:

Broadridge Content Solutions, Inc. - Jersey City NJ

International Classification:

G06Q 40/00

US Classification:

705 36R, 705 51, 705344, 705904, 705908

Abstract:

Embodiments of the invention provide techniques for improving clarity of disclosure materials provided to investors, by enabling securities issuers, intermediaries and/or other entities to create and disseminate clear and concise summary-level information on individual securities to investors to enable informed investment decisions. The information may include a summary version of the full statutory prospectus (a “summary prospectus”). A summary prospectus may include a concise, “plain English” synopsis and/or representation of certain information contained in the full statutory prospectus, such as a security's investment objectives and strategies, costs, risks and/or other information.

US Patent:

20110142760, Jun 16, 2011

Filed:

Jul 31, 2009

Appl. No.:

13/057044

Inventors:

Martin Pomper - Baltimore MD, US
Ronnie Charles Mease - Fairfax VA, US
Ying Chen - Timonium MD, US

Assignee:

The Johns Hopkins University - Baltimore MD

International Classification:

A61K 51/04
C07D 213/81
C07C 273/02
G01N 33/53
A61P 35/00

US Classification:

424 189, 546323, 564 47, 435 721

Abstract:

Prostate-specific membrane antigen (PSMA) binding compounds having radioisotope substituents are described, as well as chemical precursors thereof. Compounds include pyridine containing compounds, compounds having phenylhydrazine structures, and acylated lysine compounds. The compounds allow ready incorporation of radionuclides for single photon emission computed tomography (SPECT) and positron emission tomography (PET) for imaging, for example, prostate cancer cells and angiogenesis.

US Patent:

20110172393, Jul 14, 2011

Filed:

Mar 24, 2011

Appl. No.:

13/070664

Inventors:

Lakshmi Khandke - Nanuet NY, US
Ronald Malone - Madison NJ, US
Xudong Yang - Tappan NY, US
Hanyoung Han - Fort Lee NJ, US
Jee Loon Look - Gaithersburg MD, US
Zhaowei Jin - Cary NC, US
Ying Chen - Apex NC, US

Assignee:

WYETH LLC - Madison NJ

International Classification:

C07K 14/22

US Classification:

530350

Abstract:

The present invention addresses an ongoing need in the art to improve the stability of immunogenic compositions such as polysaccharide-protein conjugates and protein immunogens. The invention broadly relates to novel formulations which stabilize and inhibit precipitation of immunogenic compositions. More particularly, the invention described hereinafter, addresses a need in the art for formulations which stabilize and inhibit particulate formation (e.g., aggregation, precipitation) of immunogenic compositions which are processed, developed, formulated, manufactured and/or stored in container means such as fermentors, bioreactors, vials, flasks, bags, syringes, rubber stoppers, tubing and the like.

US Patent:

20110306854, Dec 15, 2011

Filed:

Apr 20, 2011

Appl. No.:

13/090836

Inventors:

Stephen Arnold - New York NY, US
Slyka Shopova - Staten Island NY, US
Ying Chen - Brooklyn NY, US
William Chin - Rego Park NY, US
Guyu Liu - Brooklyn NY, US
Raaj Haresh Rajmangal - South Ozone Park NY, US

International Classification:

A61B 5/1468
G01N 21/55

US Classification:

600310, 356445

Abstract:

A syringe-based whispering gallery mode sensor includes a syringe including an assembly provided its needle, the assembly including () an optical carrier having a reflective distal end, and () at least one resonator coupled with the optical carrier. This sensor may be provided in a system including a light source, a light detector, and a data analysis component. A method for determining the presence or concentration of a target substance in body fluid may be performed using such a system.

US Patent:

20120009121, Jan 12, 2012

Filed:

Mar 19, 2010

Appl. No.:

13/257499

Inventors:

Martin Pomper - Baltimore MD, US
Ronnie Charles Mease - Fairfax VA, US
Ray Sangeeta - Ellicott City MD, US
Ying Chen - Timonium MD, US

Assignee:

The Johns Hopkins University - Baltimore MD

International Classification:

A61K 51/00
A61K 49/00
C12N 5/00
C07D 311/82
C07D 403/06
C07D 249/04
C07D 213/53
C07F 5/02
C07F 5/00
C07C 323/22
C07D 257/02
C07F 15/00
C12Q 1/02
C07D 311/78

US Classification:

424 111, 435 29, 424 91, 435325, 549388, 548455, 549382, 546331, 546 13, 556 1, 562556, 540474, 546 2, 548255

Abstract:

Prostate-specific membrane antigen (PSMA) targeting compounds are described. Uses of the compounds for imaging, therapy, cell sorting, and tumor mapping are also described.

US Patent:

53196600, Jun 7, 1994

Filed:

May 29, 1992

Appl. No.:

7/890167

Inventors:

Ying C. Chen - Scarsdale NY
Harvey B. Serreze - Pound Ridge NY

Assignee:

McDonnell Douglas Corporation - St. Louis MO

International Classification:

H01S 319

US Classification:

372 45

Abstract:

A semiconductor laser device which provides enhanced carrier confinement. This device utilizes a single or multi-quantum well structure located between graded index confinement layers which are in turn between a pair of cladding layers. Semiconductor layers are selected such that the quantum well active region and confinement layers form a PN junction by being located between layers having N-type dopants on one side and P-type dopants on the second side for proper diode response. Within each confinement layer there is formed a plurality of multi-quantum barrier layers which serve to further increase the carrier confinement within the quantum well region by increasing the effective potential barrier within the graded index confinement region. The multi-quantum barrier layers are comprised of layers of the material forming the graded index confinement layers having alternating large and small concentrations of the material whose percentage is being varied in the graded index confinement layers.

US Patent:

48787230, Nov 7, 1989

Filed:

Feb 6, 1986

Appl. No.:

6/826644

Inventors:

Ying C. Chen - Closter NJ
Jia-ming Liu - Arlington MA
Michael A. Newkirk - Auburndale MA

Assignee:

GTE Laboratories Incorporated - Waltham MA

International Classification:

G02B 610
H01J 4014
G01B 902
H01L 2714

US Classification:

350 9614

Abstract:

An optically controlled semiconductor waveguide interferometer apparatus includes a Mach-Zehnder interferometer formed of semiconductor laser materials. A first optoelectronic switching means is adapted to be coupled across a first voltage potential and one of the optical paths of the interferometer. The first optoelectronic switching means has a first gap therein. Likewise, a second optoelectronic switching means is adapted to be coupled across a second voltage potential and the other of the optical paths. The second optoelectronic switching means has a respective gap therein. Light pulses are applied to the two gaps for controlling the index of refraction of the optical paths, whereby the light pulses control the interferometer so that the output intensity of the interferometer is modulated.