Ying Yu Chen

US Patent:

20110142760, Jun 16, 2011

Filed:

Jul 31, 2009

Appl. No.:

13/057044

Inventors:

Martin Pomper - Baltimore MD, US
Ronnie Charles Mease - Fairfax VA, US
Ying Chen - Timonium MD, US

Assignee:

The Johns Hopkins University - Baltimore MD

International Classification:

A61K 51/04
C07D 213/81
C07C 273/02
G01N 33/53
A61P 35/00

US Classification:

424 189, 546323, 564 47, 435 721

Abstract:

Prostate-specific membrane antigen (PSMA) binding compounds having radioisotope substituents are described, as well as chemical precursors thereof. Compounds include pyridine containing compounds, compounds having phenylhydrazine structures, and acylated lysine compounds. The compounds allow ready incorporation of radionuclides for single photon emission computed tomography (SPECT) and positron emission tomography (PET) for imaging, for example, prostate cancer cells and angiogenesis.

US Patent:

20120009121, Jan 12, 2012

Filed:

Mar 19, 2010

Appl. No.:

13/257499

Inventors:

Martin Pomper - Baltimore MD, US
Ronnie Charles Mease - Fairfax VA, US
Ray Sangeeta - Ellicott City MD, US
Ying Chen - Timonium MD, US

Assignee:

The Johns Hopkins University - Baltimore MD

International Classification:

A61K 51/00
A61K 49/00
C12N 5/00
C07D 311/82
C07D 403/06
C07D 249/04
C07D 213/53
C07F 5/02
C07F 5/00
C07C 323/22
C07D 257/02
C07F 15/00
C12Q 1/02
C07D 311/78

US Classification:

424 111, 435 29, 424 91, 435325, 549388, 548455, 549382, 546331, 546 13, 556 1, 562556, 540474, 546 2, 548255

Abstract:

Prostate-specific membrane antigen (PSMA) targeting compounds are described. Uses of the compounds for imaging, therapy, cell sorting, and tumor mapping are also described.

US Patent:

20200231614, Jul 23, 2020

Filed:

Oct 21, 2016

Appl. No.:

15/769865

Inventors:

- BALTIMORE MD, US
- DURHAM NC, US
YING CHEN - LUTHERVILLE-TIMONIUM MD, US
SANGEETA RAY - ELLICOTT CITY MD, US
MICHAEL ZALUTSKY - CHAPEL HILL NC, US
GANESAN VAIDYANATHAN - CHAPEL HILL NC, US

International Classification:

C07F 13/00
A61P 35/00

Abstract:

PPSMA binding scaffolds with radioiodinated, radiobrominated and radioastatinated labeled prosthetic groups are disclosed. Pharmaceutical compositions and methods of treating PSMA expressing cells or tumors also are disclosed.

US Patent:

20200109124, Apr 9, 2020

Filed:

Dec 5, 2019

Appl. No.:

16/704137

Inventors:

- Baltimore MD, US
- Sunnyvale CA, US
Ying Chen - Timonium MD, US
Sangeeta Ray - Ellicott City MD, US
Jonathan Sorger - Belmont CA, US

International Classification:

C07D 257/02
C07D 311/20
A61K 51/04
C07D 311/82
C07D 213/04
C07D 209/14
C07D 249/04
C07F 13/00
C07D 209/12
C07D 255/02
A61K 49/00
G01N 33/50
C07D 311/14
C07F 5/02
C07D 209/24

Abstract:

Compositions and methods for visualizing tissue under illumination with near-infrared radiation, including compounds comprising near-infrared, closed chain, sulfo-cyanine dyes and prostate specific membrane antigen ligands are disclosed.

US Patent:

20190225589, Jul 25, 2019

Filed:

Aug 15, 2016

Appl. No.:

15/752340

Inventors:

YING CHEN - LUTHERVILLE-TIMONIUM MD, US
XING YANG - BALTIMORE MD, US
RONNIE C. MEASE - FAIRFAX VA, US
SANGEETA RAY - ELLICOTT CITY MD, US

International Classification:

C07D 249/04
C07B 59/00

Abstract:

Triazole conjugated urea-based and thiourea-based scaffolds that have high binding affinity to PSMA are disclosed. These scaffolds can be radiolabeled and used to image cells and tumors that express PSMA. Methods of synthesizing radiofluorinated triazole conjugated urea-based and thiourea-based scaffolds also are disclosed.

US Patent:

20190175054, Jun 13, 2019

Filed:

Aug 24, 2018

Appl. No.:

16/112609

Inventors:

- College Park MD, US
- Urbana IL, US
Hugh A. Bruck - Wheaton MD, US
Ying Chen - College Park MD, US
Thenkurussi Kesavadas - Mahomet IL, US

Assignee:

University of Maryland - College Park MD
The Board of Trustees of the University of Illinois - Urbana IL

International Classification:

A61B 5/053
A61B 5/00

Abstract:

A pressure sensing system includes at least two pressure sensing layers. The first pressure sensing layer includes a first sensing system configured in a layer, a first layer of foam having a Young's modulus and mounted between a first sensing system configured in a layer, and a second sensing system configured in a layer; at least a second pressure sensing layer including the second sensing system configured in a layer, and a second layer of foam having a Young's modulus that is greater than the Young's modulus of the first layer of foam and mounted between the second sensing system configured in a layer and a rigid substrate having a Young's modulus greater than the layer of the first sensing system, the first layer of foam, the layer of the second sensing system, and the second layer of foam. The pressure sensing system thereby defines a multi-layer pressure sensing system.

US Patent:

20190177275, Jun 13, 2019

Filed:

Jun 9, 2017

Appl. No.:

16/308128

Inventors:

- Baltimore MD, US
Daniel P. Holt - Severna Park MD, US
Ying Chen - Lutherville-Timonium MD, US
Ronnie C. Mease - Fairfax VA, US
Hong Fan - Timonium MD, US
Martin G. Pomper - Baltimore MD, US
Robert F. Dannals - Sparks MD, US

International Classification:

C07D 213/42
A61P 35/00
A61K 51/04
C07B 59/00

Abstract:

Methods, and related compositions, for the improved synthesis of [F]DCFPyL are disclosed. Also provided are methods, and related compositions, for the use of [F]DCFPyL so produced.

US Patent:

20180009767, Jan 11, 2018

Filed:

Jun 9, 2017

Appl. No.:

15/618788

Inventors:

- BALTIMORE MD, US
- SUNNYVALE CA, US
YING CHEN - TIMONIUM MD, US
SANGEETA RAY - ELLICOTT CITY MD, US
JONATHAN SORGER - BELMONT CA, US

Assignee:

THE JOHNS HOPKINS UNIVERSITY - BALTIMORE MD
INTUITIVE SURGICAL OPERATIONS, INC. - SUNNYVALE CA

International Classification:

C07D 257/02
A61K 49/00
C07F 5/02
C07D 311/82
C07D 311/20
C07F 13/00
C07D 255/02
C07D 249/04
C07D 213/04
C07D 209/14
C07D 209/12
A61K 51/04
G01N 33/50
C07D 311/14

Abstract:

Compositions and methods for visualizing tissue under illumination with near-infrared radiation, including compounds comprising near-infrared, closed chain, sulfo-cyanine dyes and prostate specific membrane antigen ligands are disclosed.