Yingjie J Shen

US Patent:

20140045762, Feb 13, 2014

Filed:

Feb 17, 2012

Appl. No.:

13/985629

Inventors:

John G. Flanagan - Weston MA, US
Yingjie Shen - Brighton MA, US
Edith Yvonne Jones - Oxford, GB
Alexandru Radu Aricescu - Oxford, GB
Charlotte Hannah Bonn - Oxford, DE

Assignee:

THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY FO OXFORD - Oxford
PRESIDENT AND FELLOWS OF HARVARD COLLEGE - Cambridge MA

International Classification:

A61K 31/727
A61K 38/17

US Classification:

514 177, 435375, 514 56

Abstract:

Disclosed herein are methods of inducing neuronal outgrowth of a neuron. The methods comprise contacting the neuron with an agent that binds receptor protein tyrosine phosphatase δ (RPTPδ), to thereby induce neuronal outgrowth of the neuron. The agent may induces clustering of RPTPδ and/or inhibit binding of chondroitin sulfate proteoglycan (CSPG) to RPTPδ. Examples of suitable agents are heparan sulfate proteoglycan, heparan sulfate, heparan sulfate oligosaccharides, or heparin oligosaccharides. Additional agents are also disclosed. The neuron can be a CNS neuron or peripheral neuron. Also disclosed herein are methods of treating neuronal injury in a subject comprising, administering to the subject an agent that binds RPTPδ. Administration may be to a site of neuronal injury, to thereby induce neuronal outgrowth at the site of neuronal injury.

US Patent:

20120231014, Sep 13, 2012

Filed:

Aug 18, 2010

Appl. No.:

13/391210

Inventors:

John G. Flanagan - Weston MA, US
Alan Peter Tenney - New York NY, US
Yingjie Shen - Brighton MA, US
Jerry Silver - Bay Village OH, US

Assignee:

CASE WESTERN RESERVE UNIVERSITY - Cleveland OH
PRESIDENT AND FELLOWS OF HARVARD COLLEGE - Cambridge MA

International Classification:

A61K 39/395
A61P 25/00
A61K 38/46
A61K 38/17
C12N 5/0793
C12N 5/071

US Classification:

4241581, 435375, 424 946, 514 177, 4241721

Abstract:

A method of promoting neural cell regeneration is carried out by contacting a neural cell with a compound that inhibits the binding of a chondroitin sulfate proteoglycan (CSPG) to a cellular (e.g., trans-membrane) PTPσ protein. The neural cell is associated with an injury or neurodegenerative condition.