Yong Ming Li - Fresh Meadows NY Helen Vlassara - Shelter Island NY Anthony Cerami - Shelter Island NY
Assignee:
The Picower Institute for Medical Research - Manhasset NY
International Classification:
C12Q 134 C12Q 100 G01N 33566
US Classification:
435 18
Abstract:
The present invention is directed to methods for detecting the presence of advanced glycosylation endproducts using the unexpected discovery that certain antibacterial proteins, in particular lysozyme and lactoferrin, bind to advanced glycosylation endproducts (AGEs) with high affinity, and that this binding activity is substantially noncompetitive with binding of bacterial carbohydrates to the antibacterial proteins. Accordingly, the invention relates to diagnostic methods for diseases and disorders associated with increased levels of AGEs, by using compositions having associated therewith a molecule having a hydrophilic loop domain, which domain is associated with AGE-binding activity, and compositions comprising such a domain. The invention further relates to compositions and devices for partitioning AGEs away from a sample.
Methods For Inhibiting The Cross-Linking Of Advanced Glycosylation Endproducts
Yong Ming Li - Fresh Meadows NY Helen Vlassara - Shelter Island NY Anthony Cerami - Shelter Island NY
Assignee:
The Picower Institute for Medical Research - Manhasset NY
International Classification:
A61K 3847 A61K 3816
US Classification:
424 9461
Abstract:
The present invention is directed to methods for inhibiting the cross-linking of advanced glycosylation endproducts in a subject suspected of having elevated levels of AGEs by using the unexpected discovery that certain antibacterial proteins, in particular lysozyme and particular fragments thereof, bind to advanced glycosylation endproducts (AGEs) with high affinity, and that this binding activity is substantially noncompetitive with binding of bacterial carbohydrates to the antibacterial proteins. Accordingly, the invention relates to therapeutic methods for treating diseases and disorders associated with increased levels of AGEs, by using compositions having associated therewith a molecule having a hydrophilic loop domain, which domain is associated with AGE-binding activity, and compositions comprising such a domain to remove AGEs from biological material. The invention further relates to compositions for inhibiting the cross-linking of AGEs in a subject in need of such therapy.
Methods For Partitioning Advanced Glycosylation Endproducts
Yong Ming Li - Fresh Meadows NY Helen Vlassara - Shelter Island NY Anthony Cerami - Shelter Island NY
Assignee:
The Picower Institute for Medical Research - Manhasset NY
International Classification:
A01N 102 C12N 936 A61K 3803
US Classification:
435 2
Abstract:
The present invention is directed to methods for partitioning advanced glycosylation endproducts out of a biological sample using the unexpected discovery that certain antibacterial proteins, in particular lysozyme and particular fragments thereof, bind to advanced glycosylation endproducts (AGEs) with high affinity, and that this binding activity is substantially noncompetitive with binding of bacterial carbohydrates to the antibacterial proteins. Accordingly, the invention relates to therapeutic methods for treating diseases and disorders associated with increased levels of AGEs, by using compositions having associated therewith a molecule having a hydrophilic loop domain, which domain is associated with AGE-binding activity, and compositions comprising such a domain to remove AGEs from biological material. The invention further relates to compositions and devices for partitioning AGEs away from a sample.
Compositions And Devices For Partitioning Advanced Glycosylation Endproducts, And Methods Of Their Use
Yong Ming Li - Fresh Meadows NY Helen Vlassara - Shelter Island NY Anthony Cerami - Shelter Island NY
Assignee:
The Picower Institute for Medical Research - Manhasset NY
International Classification:
B01D 1104 A01N 102
US Classification:
210646
Abstract:
The present invention is directed to compositions and devices based upon the unexpected discovery that certain antibacterial proteins, in particular lysozyme and lactoferrin, bind to advanced glycosylation endproducts (AGEs) with high affinity, and that this binding activity is substantially noncompetitive with binding of bacterial carbohydrates to the antibacterial proteins. Accordingly, the invention relates to methods for treating diseases and disorders associated with increased levels of AGEs, by using compositions and devices having associated therewith a molecule having a hydrophilic loop domain, which domain is associated with AGE-binding activity, and compositions comprising such a domain. The invention further relates to compositions and devices for partitioning AGEs away from a sample.
Nov 2013 to 2000 Pharmacy TechnicianMontgomery County Police Department Montgomery County, M, MD Aug 2013 to Oct 2013 Police Officer CandidateCVS Pharmacy Woburn, MA Apr 2013 to Aug 2013 Private InvestigatorCVS Pharmacy Kensington, MD Mar 2013 to Aug 2013 Pharmacy TechnicianSpecial Investigations Division Rockville, MD Jul 2012 to Dec 2012 Gang AnalystSpecial Investigations Division Rockville, MD Oct 2011 to Jul 2012 Intern
Education:
University of Maryland College Park, MD May 2008 to May 2012 Bachelor of Arts in Criminal Justice
Name / Title
Company / Classification
Phones & Addresses
Yong Li Owner
Wah Chun Take Out Kitchen Eating Place
23119 Merrick Blvd, Jamaica, NY 11413
Yong Li President
NORTHBROOK PROPERTIES LLC
Yong J. Li Owner
MONTAGUE LAUNDRY, INC Coin-Operated Laundry
78 Montague St, Brooklyn, NY 11201 140 Montague St, Brooklyn, NY 11201
Los Angeles, CA 90045 1225 W 190 St SUITE 340, Gardena, CA 90248 New York Br 1984 69 St / #A, Brooklyn, NY 11204 5250 W Century Blvd #660, Los Angeles, CA 90045 3104179988
Dr. Li graduated from the Shanghai Med Univ, Shanghai First Med Univ, Shanghai, China in 1991. He works in Oshkosh, WI and 2 other locations and specializes in Psychiatry. Dr. Li is affiliated with Theda Care Regional Medical Center and Thedacare Regional Medical Center Appleton.
Dr. Li graduated from the Shanghai Med Univ, Shanghai First Med Univ, Shanghai, China in 1968. He works in Pearland, TX and specializes in Family Medicine and Acupuncturist. Dr. Li is affiliated with Baylor St Lukes Medical Center and The Womans Hospital Of Texas.
Counseling & Psychological Services At The University Of Pennsylvania 3624 Market St STE 1W, Philadelphia, PA 19104 2158987021 (phone), 2155738966 (fax)
Education:
Medical School Beijing Med Univ, Beijing City, Beijing, China Graduated: 1986
St GallenPast: Associate Director of Strategic Investment Department at Huashang Media Group Co Ltd... mature, self-motivated, and ambitious;
in-depth knowledge & understanding in China’s society and economy;
connections to Chinese entrepreneurs, capital... mature, self-motivated, and ambitious;
in-depth knowledge & understanding in China’s society and economy;
connections to Chinese entrepreneurs, capital market, and media/publishing industry;
experience in business development and making investment in media industry;
working experience in US...