Yong Lin

US Patent:

20110318741, Dec 29, 2011

Filed:

Jun 15, 2011

Appl. No.:

13/161201

Inventors:

Peter H. SCHAFER - Somerset NJ, US
Yong Lin - Brooklyn NY, US
Donna Sutherland - Green Brook NJ, US

International Classification:

C12Q 1/68
G01N 33/566

US Classification:

435 611, 435 721, 435 724, 435 613, 435 612

Abstract:

Provided herein are the biomarkers for predicting or monitoring the efficacy of a treatment for psoriasis. The use of certain cell markers and mRNA levels as biomarkers to predict whether a psoriasis treatment is likely to be successful is also provided. Further, the expression of these genes or cell markers can be used to monitor progress of treatment effectiveness and patient compliance in psoriasis patients who are receiving treatment.

US Patent:

20160103138, Apr 14, 2016

Filed:

Apr 30, 2014

Appl. No.:

14/888075

Inventors:

Yong Y. LIN - Bridgewater NJ, US
Shuren MA - Cliffside Park NJ, US
Gerard M. TURINO - New York NY, US
Toyonobu USUKI - Tokyo, JP

International Classification:

G01N 33/68
A61K 38/57
G01N 30/72

Abstract:

The present invention provides, inter alia, methods for measuring the amount of a marker of elastic fiber injury in a sample. The methods include contacting a sample with a compound of formula (1) and carrying out mass spectrometry on the sample containing the compound of formula (1). Also provided are methods of diagnosing whether a subject has a disease characterized by elastic fiber injury, a method for improving the accuracy and precision of mass spectroscopy analysis of a marker of elastic fiber injury, and kits for determining, by mass spectrometry, the amount of a marker of elastic fiber injury in a sample from a subject. Further provided are methods for preventing the progression of the effects associated with alpha-1 antitrypsin deficiency (AATD) in a subject with normal lung function.